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Start Over Author "Jeremy M. C. Brown" Topic 0302 clinical medicine
14 results on '"Jeremy M. C. Brown"'

1. Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group

Author

Dosatsu Sakata, David Bolst, D. H. Wright, Mihaly Novak, A. Perales, Edward Simpson, Christian Fedon, F. Romano, Paolo Dondero, Luciano Pandola, Ioanna Kyriakou, Bruce A. Faddegon, Toshiyuki Toshito, M. A. Cortés-Giraldo, Dmitri Konstantinov, Marie-Claude Bordage, Anatoly B. Rosenfeld, Luis Sarmiento, Yann Perrot, Pedro Arce, Giacomo Cuttone, Vladimir Ivanchenko, Carlo Mancini-Terracciano, Chihiro Omachi, J. M. Quesada, Sebastien Incerti, Dean L Cutajar, M. Maire, Ioannis Sechopoulos, José Ramos-Méndez, P. Cirrone, A. Le, Jeremy M. C. Brown, Susanna Guatelli, A. Mantero, G. Latyshev, Andrea Dotti, Giada Petringa, Laurent Desorgher, Takashi Sasaki, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)

Subjects
Monte Carlo method, Geant4, medical physics, CROSS-SECTIONS, 030218 nuclear medicine & medical imaging, DOSE POINT KERNELS, 0302 clinical medicine, MEV ELECTRONS, benchmarking, Monte Carlo, [PHYS]Physics [physics], PROTON-THERAPY, Large Hadron Collider, medical applications, Medical simulation, Physics, STOPPING-LENGTH TARGETS, Observable, General Medicine, Benchmarking, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Other Physical Sciences, Nuclear Medicine & Medical Imaging, 030220 oncology & carcinogenesis, MULTIPLE-SCATTERING, MONTE-CARLO-SIMULATION, Monte Carlo simulations, radiotherapy, hadrotherapy, Monte Carlo Method, medicine.medical_specialty, Oncology and Carcinogenesis, Biomedical Engineering, Article, 03 medical and health sciences, Regression testing, medicine, Web application, Medical physics, Computer Simulation, BACKSCATTERING COEFFICIENT, Radiometry, radiotherapy, business.industry, THICK TARGETS, hadrotherapy, Reference data, NEUTRON YIELDS, business
Abstract

Background: Geant4 is a Monte Carlo code extensively used in medical physics for a wide range of applications, such as dosimetry, micro- and nanodosimetry, imaging, radiation protection, and nuclear medicine. Geant4 is continuously evolving, so it is crucial to have a system that benchmarks this Monte Carlo code for medical physics against reference data and to perform regression testing. Aims: To respond to these needs, we developed G4-Med, a benchmarking and regression testing system of Geant4 for medical physics. Materials and Methods: G4-Med currently includes 18 tests. They range from the benchmarking of fundamental physics quantities to the testing of Monte Carlo simulation setups typical of medical physics applications. Both electromagnetic and hadronic physics processes and models within the prebuilt Geant4 physics lists are tested. The tests included in G4-Med are executed on the CERN computing infrastructure via the use of the geant-val web application, developed at CERN for Geant4 testing. The physical observables can be compared to reference data for benchmarking and to results of previous Geant4 versions for regression testing purposes. Results: This paper describes the tests included in G4-Med and shows the results derived from the benchmarking of Geant4 10.5 against reference data. Discussion: Our results indicate that the Geant4 electromagnetic physics constructor G4EmStandardPhysics_option4 gives a good agreement with the reference data for all the tests. The QGSP_BIC_HP physics list provided an overall adequate description of the physics involved in hadron therapy, including proton and carbon ion therapy. New tests should be included in the next stage of the project to extend the benchmarking to other physical quantities and application scenarios of interest for medical physics. Conclusion: The results presented and discussed in this paper will aid users in tailoring physics lists to their particular application. Ministerio de Economía y Competitividad FPA2016-77689-C2-1-R National Institutes of Health U24CA215123 France-Greece PICS 8235 European Space Agency 4000126645/19/NL/BW Australian Research Council ARC DP170100967, DP170102423 Susan G Komen Foundation for the Cure IIR13262248

Published
2021
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2. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Author

Shogo Okada, Dousatsu Sakata, K. Murakami, David Sarramia, Vladimir Ivanchenko, Mario A. Bernal, Ivan Petrović, Sebastien Incerti, Ioanna Kyriakou, Marie-Claude Bordage, Wook Geun Shin, Sylvain Meylan, H.N. Tran, Dimitris Emfietzoglou, David Bolst, Takashi Sasaki, Giovanni Santin, Carmen Villagrasa, Vincent Breton, Nicolas Tang, Oleg Belov, Susanna Guatelli, Petteri Nieminen, Nathanael Lampe, Aleksandra Ristić-Fira, Jeremy M. C. Brown, Ziad Francis, M. Karamitros, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de dosimétrie des rayonnements ionisants (IRSN/PSE-SANTE/SDOS/LDRI), Service de dosimétrie (IRSN/PSE-SANTE/SDOS), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN)

Subjects
Radiobiology, Time Factors, DNA damage, Monte Carlo method, Biophysics, General Physics and Astronomy, Radiation, Models, Biological, 030218 nuclear medicine & medical imaging, Ionizing radiation, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Radiology, Nuclear Medicine and imaging, DNA Breaks, Double-Stranded, DNA Breaks, Single-Stranded, Monte Carlo simulation, Physics, Cell Nucleus, [PHYS]Physics [physics], Geant4-DNA, business.industry, General Medicine, Chromatin, medicine.anatomical_structure, Fractals, 030220 oncology & carcinogenesis, Radiation protection, business, Nucleus, Monte Carlo Method, DNA Damage
Abstract

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. © 2019 Associazione Italiana di Fisica Medica

Published
2019
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3. In-silico optimisation of tileable philips digital SiPM based thin monolithic scintillator detectors for SPECT applications

Author

Jeremy M. C. Brown

Subjects
Physics - Instrumentation and Detectors, Materials science, Monte Carlo method, FOS: Physical sciences, Geant4, Photodetector, Scintillator, 010403 inorganic & nuclear chemistry, 01 natural sciences, Particle detector, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Silicon photomultiplier, Figure of merit, Image resolution, Radiation instrumentation, Gamma-ray detector, Radiation, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Physics - Medical Physics, 0104 chemical sciences, SPECT, Optoelectronics, Medical Physics (physics.med-ph), business, SPECT/MR
Abstract

Over the last decade one of the most significant technological advances made in the field of radiation detectors for nuclear medicine was the development of Silicon Photomultipler (SiPM) sensors. At present only a small number of SiPM based radiation detectors for Single Photon Emission Computed Tomography (SPECT) applications have been explored, and even fewer experimental prototypes developed. An in-silico investigation into the optimal design of a Philips DPC3200 SiPM photosensor-based thin monolithic scintillator detector for SPECT applications was undertaken using the Monte Carlo radiation transport modelling toolkit Geant4 version 10.5. The performance of the 20 different SPECT radiation detector configurations, 4 scintillator materials (NaI(Tl), GAGG(Ce), CsI(Tl) and LaBr3(Ce)) and 5 thicknesses (1–5 mm), were determined through the use of seven figures of merit. It was found that a crystal thickness range of 4–5 mm was required for all four materials to ensure acceptable energy resolution, sensitivity and spatial resolution performance with the Philips DPC3200 SiPM. Any thinner than this and the performance of all four materials was found to degrade rapidly due to a high probability of material specific fluorescence x-ray escape after incident gamma/x-ray photoelectric absorption. When factoring in each material's magnetic resonance imaging compatibility, hygroscopy, and cost, it was found that CsI(Tl) represents the most promising material to construct tileable Philips digital SiPM based thin monolithic scintillator detectors for SPECT applications.

Published
2021
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4. Simulation of Auger electron emission from nanometer-size gold targets using the Geant4 Monte Carlo simulation toolkit

Author

B. Suerfu, A. Mantero, Mario A. Bernal, Jeremy M. C. Brown, V. Ivantchenko, Ziad Francis, Sebastien Incerti, H.N. Tran, M. Karamitros, and J. Xu

Subjects
Physics, Nuclear and High Energy Physics, Auger electron spectroscopy, Photon, Auger effect, Proton, Physics::Medical Physics, Monte Carlo method, Spectral line, 030218 nuclear medicine & medical imaging, Computational physics, Auger, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, 030220 oncology & carcinogenesis, symbols, Nanomedicine, Atomic physics, Instrumentation
Abstract

A revised atomic deexcitation framework for the Geant4 general purpose Monte Carlo toolkit capable of simulating full Auger deexcitation cascades was implemented in June 2015 release (version 10.2 Beta). An overview of this refined framework and testing of its capabilities is presented for the irradiation of gold nanoparticles (NP) with keV photon and MeV proton beams. The resultant energy spectra of secondary particles created within and that escape the NP are analyzed and discussed. It is anticipated that this new functionality will improve and increase the use of Geant4 in the medical physics, radiobiology, nanomedicine research and other low energy physics fields.

Published
2016
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5. Advances in Geant4 applications in medicine

Author

Sebastien Incerti, Susanna Guatelli, Jeremy M. C. Brown, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), and Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], Materials science, business.industry, Monte Carlo method, Biophysics, MEDLINE, General Physics and Astronomy, General Medicine, 030218 nuclear medicine & medical imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Software, 030220 oncology & carcinogenesis, Systems engineering, Radiology, Nuclear Medicine and imaging, business
Abstract

International audience; The 3rd Geant4 International Conference at the Physics-Medicine-Biology Frontier, 29–31 October 2018, was organized in Bordeaux, France, by the Centre d'Etudes Nucléaires de Bordeaux-Gradignan (http://www.cenbg.in2p3.fr), a CNRS/IN2P3 and Bordeaux University research laboratory. The conference was chaired by Sébastien Incerti (CNRS/IN2P3, Bordeaux, France), with the support of two co-chairs Jeremy M. C. Brown (TUDelft, Delft, The Netherlands) and Susanna Guatelli (Wollongong University, Wollongong, Australia).

Published
2018
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6. Progress of Geant4 electromagnetic physics developments and applications

Author

Mihaly Novak, Samer Bakr, A. S. Howard, Ioanna Kyriakou, D. Bernard, Helmut Burkhardt, Farah Hariri, Marilena Bandieramonte, Soon Yung Jun, I. Semeniouk, Sebastien Incerti, Sabine Elles, Vladimir Grichine, D Sawkey, Jeremy M. C. Brown, Vladimir Ivanchenko, M. Maire, L. Urbán, O Kadri, Marie-Claude Bordage, Susanna Guatelli, Paolo Dondero, A. Mantero, Alexander Bagulya, Anton V. Sokolov, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Geant4 Collaboration, and Laboratoire d'Annecy de Physique des Particules (LAPP)

Subjects
Physics, Free electron model, Large Hadron Collider, [PHYS.PHYS]Physics [physics]/Physics [physics], 010308 nuclear & particles physics, Scattering, QC1-999, Bremsstrahlung, Electron, Photoelectric effect, 01 natural sciences, 030218 nuclear medicine & medical imaging, Computing and Computers, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Positron, 0103 physical sciences, Nuclear Physics - Experiment, Electron scattering
Abstract

International audience; We report on developments of the Geant4 electromagnetic physics sub-libraries of Geant4 release 10.4 and beyond. Modifications are introduced to the models of photoelectric effect, bremsstrahlung, gamma conversion, single and multiple scattering. The theory-based Goudsmit-Saunderson model of electron/positron multiple scattering has been recently reviewed and a new improved version, providing the most accurate results for scattering of electrons and positrons, was made available. The updated interfaces, models and configurations have already been integrated into LHC applications and may be useful for any type of simulations

Published
2018
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7. Statistical Image Reconstruction for High-Throughput Thermal Neutron Computed Tomography

Author

Daniele Pelliccia, Jeremy M. C. Brown, and Ulf Garbe

Subjects
Physics, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, business.industry, Neutron imaging, Neutron tomography, FOS: Physical sciences, 02 engineering and technology, Filter (signal processing), Iterative reconstruction, Instrumentation and Detectors (physics.ins-det), 021001 nanoscience & nanotechnology, Neutron temperature, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Neutron, Computer vision, Tomography, Artificial intelligence, 0210 nano-technology, business, Instrumentation, Throughput (business)
Abstract

Neutron Computed Tomography (CT) is an increasingly utilised non-destructive analysis tool in material science, palaeontology, and cultural heritage. With the development of new neutron imaging facilities (such as DINGO, ANSTO, Australia) new opportunities arise to maximise their performance through the implementation of statistically driven image reconstruction methods which have yet to see wide scale application in neutron transmission tomography. This work outlines the implementation of a convex algorithm statistical image reconstruction framework applicable to the geometry of most neutron tomography instruments with the aim of obtaining similar imaging quality to conventional ramp filtered back-projection via the inverse Radon transform, but using a lower number of measured projections to increase object throughput. Through comparison of the output of these two frameworks using a tomographic scan of a known 3 material cylindrical phantom obtain with the DINGO neutron radiography instrument (ANSTO, Australia), this work illustrates the advantages of statistical image reconstruction techniques over conventional filter back-projection. It was found that the statistical image reconstruction framework was capable of obtaining image estimates of similar quality with respect to filtered back-projection using only 12.5% the number of projections, potentially increasing object throughput at neutron imaging facilities such as DINGO eight-fold.

Published
2018

8. Mechanistic DNA damage simulations in Geant4-DNA part 1: A parameter study in a simplified geometry

Author

Vincent Breton, M. Karamitros, David Sarramia, Jeremy M. C. Brown, Dousatsu Sakata, Ioanna Kyriakou, Nathanael Lampe, Sebastien Incerti, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont ( LPC ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)

Subjects
Models, Molecular, Work (thermodynamics), DNA damage, Monte Carlo method, Biophysics, General Physics and Astronomy, Electrons, Geometry, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Low energy, Radiology, Nuclear Medicine and imaging, Physics, [PHYS]Physics [physics], [ PHYS ] Physics [physics], DNA, General Medicine, Highly sensitive, chemistry, 030220 oncology & carcinogenesis, Yield (chemistry), Nucleic Acid Conformation, Monte Carlo Method, DNA Damage, Single strand
Abstract

International audience; Mechanistic modelling of DNA damage in Monte Carlo simulations is highly sensitive to the parameters that define DNA damage. In this work, we use a simple testing geometry to investigate how different choices of physics models and damage model parameters can change the estimation of DNA damage in a mechanistic DNA damage simulation built in Geant4-DNA. The choice of physics model can lead to variations by up to a factor of two in the yield of physically induced strand breaks, and the parameters that determine scavenging, and physical and chemical single strand break induction can have even larger consequences. Using low energy electrons as primary particles, a variety of parameters are tested in this geometry in order to arrive at a parameter set consistent with past simulation studies. We find that the modelling of scavenging can play an important role in determining results, and speculate that high-scavenging regimes, where only chemical radicals within 1 nm of DNA are simulated, could provide a good means of testing mechanistic DNA simulations

Published
2018
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9. Mechanistic DNA damage simulations in Geant4-DNA Part 2: Electron and proton damage in a bacterial cell

Author

Dousatsu Sakata, M. Karamitros, Sebastien Incerti, Vincent Breton, David Sarramia, Jeremy M. C. Brown, Nathanael Lampe, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université de Bordeaux (UB), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont ( LPC ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Bordeaux ( UB ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
DNA, Bacterial, Models, Molecular, Mutation rate, Proton, DNA damage, Biophysics, General Physics and Astronomy, Electrons, Radiation, medicine.disease_cause, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Escherichia coli, medicine, Radiology, Nuclear Medicine and imaging, Scavenging, [PHYS]Physics [physics], Range (particle radiation), [ PHYS ] Physics [physics], General Medicine, chemistry, 030220 oncology & carcinogenesis, Nucleic Acid Conformation, Protons, Monte Carlo Method, DNA, DNA Damage
Abstract

International audience; We extended a generic Geant4 application for mechanistic DNA damage simulations to an Escherichia coli cell geometry, finding electron damage yields and proton damage yields largely in line with experimental results. Depending on the simulation of radical scavenging, electrons double strand breaks (DSBs) yields range from 0.004 to 0.010 DSB Gy-1 Mbp-1, while protons have yields ranging from 0.004 DSB Gy-1 Mbp-1 at low LETs and with strict assumptions concerning scavenging, up to 0.020 DSB Gy-1 Mbp-1 at high LETs and when scavenging is weakest. Mechanistic DNA damage simulations can provide important limits on the extent to which physical processes can impact biology in low background experiments. We demonstrate the utility of these studies for low dose radiation biology calculating that in E. coli, the median rate at which the radiation background induces double strand breaks is 2.8 × 10-8 DSB day-1, significantly less than the mutation rate per generation measured in E. coli, which is on the order of 10-3.

Published
2018
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10. Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project

Author

Sylvain Meylan, Dosatsu Sakata, Sang Bae Lee, Vladimir Ivanchenko, Carmen Villagrasa, Ziad Francis, Sebastien Incerti, Chul Hee Min, Susanna Guatelli, Marie-Claude Bordage, Mario A. Bernal, Ioanna Kyriakou, Wook Geun Shin, H.N. Tran, M. Karamitros, Jeremy M. C. Brown, Nathanael Lampe, Pentti Nieminen, Nicolas Tang, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)

Subjects
Structure (mathematical logic), [PHYS]Physics [physics], Monte Carlo method, General Medicine, Track (rail transport), 030218 nuclear medicine & medical imaging, Computational science, Set (abstract data type), 03 medical and health sciences, Range (mathematics), 0302 clinical medicine, 030220 oncology & carcinogenesis, Stopping power (particle radiation), Point (geometry), Physical quantity
Abstract

International audience; This Special Report presents a description of Geant4‐DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…). These example applications are included in the Geant4 Monte Carlo toolkit and are available in open access. Each application is described and comparisons to recent international recommendations are shown (e.g., ICRU, MIRD), when available. The influence of physics models available in Geant4‐DNA for the simulation of electron interactions in liquid water is discussed. Thanks to these applications, the authors show that the most recent sets of physics models available in Geant4‐DNA (the so‐called “option4” and “option 6” sets) enable more accurate simulation of stopping powers, dose point kernels, and W‐values in liquid water, than the default set of models (“option 2”) initially provided in Geant4‐DNA. They also serve as reference applications for Geant4‐DNA users interested in TS simulations.

Published
2018
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11. Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

Author

Hervé Seznec, Vincent Breton, Pierre Marin, Lydia Maigne, Jeremy M. C. Brown, Sebastien Incerti, David Sarramia, Nathanael Lampe, David Biron, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), School of Mathematics and Physics [Belfast], Queen's University [Belfast] (QUB), Interface Physique et Chimie pour le Vivant (IPCV), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Mutation rate, Radiobiology, lcsh:Medicine, 030218 nuclear medicine & medical imaging, Ionizing radiation, 0302 clinical medicine, Radiation, Ionizing, Radiative transfer, Relative biological effectiveness, Background Radiation, lcsh:Science, [PHYS]Physics [physics], Physics, Likelihood Functions, Muons, Multidisciplinary, Radiation, Simulation and Modeling, Physical Sciences, Elementary Particles, Research Article, Electrons, Research and Analysis Methods, [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, Microbiology, 03 medical and health sciences, Escherichia coli, Genetics, Point Mutation, Computer Simulation, Particle Physics, Nuclear Physics, Nucleons, Evolutionary Biology, Bacterial Evolution, business.industry, lcsh:R, Biology and Life Sciences, Dose-Response Relationship, Radiation, Bacteriology, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Organismal Evolution, Computational physics, 030104 developmental biology, 13. Climate action, Mutation, Ionizing Radiation, Microbial Evolution, Particle, lcsh:Q, Dose rate, Nuclear medicine, business
Abstract

International audience; At very low radiation dose rates, the effects of energy depositions in cells by ionizing radiation is best understood stochastically, as ionizing particles deposit energy along tracks separated by distances often much larger than the size of cells. We present a thorough analysis of the stochastic impact of the natural radiative background on cells, focusing our attention on E. coli grown as part of a long term evolution experiment in both underground and surface laboratories. The chance per day that a particle track interacts with a cell in the surface laboratory was found to be 6 × 10−5 day−1, 100 times less than the expected daily mutation rate for E. coli under our experimental conditions. In order for the chance cells are hit to approach the mutation rate, a gamma background dose rate of 20 μGy hr−1 is predicted to be required.

Published
2016
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12. Recent developments in Geant4

Author

Vladimir Grichine, Sebastien Incerti, G.O. Depaola, A. Galoyan, Andrea Dotti, Maria A.M. Reis, T. Yamashita, Enrico Bagli, Davide Mancusi, Ziad Francis, Helmut Burkhardt, J. I. Shin, Pekka Kaitaniemi, K. Amako, Tatsumi Koi, M. Raine, Pedro Arce, Ivan Petrović, John Allison, Nicolas A. Karakatsanis, D. Sawkey, Alexey Bogdanov, Victor Daniel Elvira, Giovanni Santin, X. Dong, Douglas Wright, M.H. Kelsey, S. Y. Jun, Maria Grazia Pia, K. Murakami, P. Gumplinger, S. B. Lee, Makoto Asai, J Perl, Jerome Verbeke, V. V. Uzhinsky, S. Hwang, J. M. Quesada, D. Brandt, Vladimir Ivanchenko, L. Garnier, Giorgio Ivan Russo, A. Mantero, Alexander Bagulya, Francesco Longo, B. Morgan, G. Barrand, Susanna Guatelli, T. Nikitina, Igor Strakovsky, H.N. Tran, Francesco Romano, B. R. Beck, Sw. Banerjee, D. Cano-Ott, M. Gayer, F.W. Jones, Ph Canal, Luciano Pandola, Paul Gueye, Toshiyuki Toshito, M. A. Cortés-Giraldo, Kyung-Suk Cho, Tsukasa Aso, A. Ristic Fira, Alexander Howard, G. Cosmo, Gunter Folger, John Apostolakis, Hisaya Kurashige, Giacomo Cuttone, Ivana Hřivnáčová, B. Tome, E. Mendoza, Stephane Chauvie, M. Karamitrosi, A. Taborda, Gene Cooperman, Satoshi Tanaka, H. Wenzel, B. Wendt, K. Genser, Takashi Sasaki, D. H. Wright, Pete Truscott, L. Urbán, Alberto Ribon, M. Verderi, P. Paprocki, M. Maire, A. Ivanchenko, Akinori Kimura, W. Pokorski, H. Yoshida, Jeremy M. C. Brown, A. Lechner, G.A.P. Cirrone, J. Yarba, Laurent Desorgher, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire d'Orsay (IPNO), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Service des Réacteurs et de Mathématiques Appliquées (SERMA), Département de Modélisation des Systèmes et Structures (DM2S), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Service d’Études des Réacteurs et de Mathématiques Appliquées (SERMA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Allison, J., Amako, K., Apostolakis, J., Arce, P., Asai, M., Aso, T., Bagli, E., Bagulya, A., Banerjee, S., Barrand, G., Beck, B. R., Bogdanov, A. G., Brandt, D., Brown, J. M. C., Burkhardt, H., Canal, Ph., Cano-Ott, D., Chauvie, S., Cho, K., Cirrone, G. A. P., Cooperman, G., Cortés-Giraldo, M. A., Cosmo, G., Cuttone, G., Depaola, G., Desorgher, L., Dong, X., Dotti, A., Elvira, V. D., Folger, G., Francis, Z., Galoyan, A., Garnier, L., Gayer, M., Genser, K. L., Grichine, V. M., Guatelli, S., Guãye, P., Gumplinger, P., Howard, A. S., Hřivnã¡čovã¡, I., Hwang, S., Incerti, S., Ivanchenko, A., Ivanchenko, V. N., Jones, F. W., Jun, S. Y., Kaitaniemi, P., Karakatsanis, N., Karamitrosi, M., Kelsey, M., Kimura, A., Koi, T., Kurashige, H., Lechner, A., Lee, S. B., Longo, F., Maire, M., Mancusi, D., Mantero, A., Mendoza, E., Morgan, B., Murakami, K., Nikitina, T., Pandola, L., Paprocki, P., Perl, J., Petrović, I., Pia, M. G., Pokorski, W., Quesada, J. M., Raine, M., Reis, M. A., Ribon, A., Ristić Fira, A., Romano, F., Russo, G., Santin, G., Sasaki, T., Sawkey, D., Shin, J. I., Strakovsky, I. I., Taborda, A., Tanaka, S., Tomã©, B., Toshito, T., Tran, H. N., Truscott, P. R., Urban, L., Uzhinsky, V., Verbeke, J. M., Verderi, M., Wendt, B. L., Wenzel, H., Wright, D. H., Wright, D. M., Yamashita, T., Yarba, J., and Yoshida, H.

Subjects
MONTE-CARLO DOSIMETRY, LIQUID WATER, Nuclear and High Energy Physics, Exploit, PAIR PRODUCTION, MODELS, Nuclear physics, ENERGY ELECTROMAGNETIC, HEAVY-ION COLLISIONS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, QA76, 030218 nuclear medicine & medical imaging, High energy physic, 03 medical and health sciences, 0302 clinical medicine, Software, HADRON-NUCLEUS, 0103 physical sciences, PHYSICS PROCESSES, Statistical physics, High energy physics, Adaptation (computer science), Instrumentation, QC, Computing, Radiation, Simulation, ComputingMilieux_MISCELLANEOUS, Nuclear and High Energy Physic, Physics, Physics::Computational Physics, 010308 nuclear & particles physics, business.industry, Detector, NUCLEUS CROSS-SECTIONS, SPACE EVENT GENERATOR, Variety (cybernetics), Visualization, Computing and Computers, MICRODOSIMETRY SIMULATION, Nuclear physic, Multithreading, Nuclear Physics - Theory, Systems engineering, Space Science, business
Abstract

Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here., Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835, ISSN:0168-9002, ISSN:1872-9576

Published
2016
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13. Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

Author

T. V. Nhan Hao, Sang Bae Lee, Ziad Francis, K. Murakami, Philippe Barberet, M Bordage, M. Karamitros, Susumu Okada, T T Tran, Takashi Sasaki, Susanna Guatelli, James Shin, Mario A. Bernal, H.N. Tran, Z. El Bitar, Sally McKinnon, Vladimir Ivanchenko, Sebastian Incerti, Jeremy M. C. Brown, High Energy Accelerator Research Organization (KEK), University of Tsukuba, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Faculty of Sciences, Université Saint-Joseph de Beyrouth (USJ), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), KEK (High energy accelerator research organization), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, Materials science, Proton, Geant4-DNA, Monte Carlo method, Radiochemistry, Nanoparticle, 030218 nuclear medicine & medical imaging, Proton beam, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, Colloidal gold, 030220 oncology & carcinogenesis, Absorbed dose, Radiolysis, Irradiation, Proton therapy, Instrumentation
Abstract

International audience; Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due totheir ability to increase energy deposition and subsequent direct damage to cells and DNA within theirlocal vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemicalyields. In this work we present, for the first time, an in silico investigation, based on the general purposeMonte Carlo simulation toolkit Geant4, into energy deposition and radical species production around aspherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed forincident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.

Published
2016
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14. Comparison of Geant4-DNA simulation of S-values with other Monte Carlo codes

Author

Mario A. Bernal, C. Le Loirec, Manuel Bardiès, Ph. Barberet, L. Campos, C. Zacharatou, Marie-Claude Bordage, Jeremy M. C. Brown, M. Karamitros, Yann Perrot, Filippo Morini, Michel Fromm, B. Mascialino, Ziad Francis, Christophe Champion, Michael S. Deleuze, Vladimir Ivanchenko, T. André, J.-E. Groetz, R. Delorme, Sebastien Incerti, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hasselt University (UHasselt), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire Modélisation et Simulation de Systèmes (LM2S), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), LAboratoire PLasma et Conversion d'Energie (LAPLACE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Monash University [Melbourne], Institut Bergonié [Bordeaux], UNICANCER, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), supported by the INSERM PhysiCancer 'MICRONAUTE' project (2013–2014)., Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hasselt University, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Institut Bergonié - CRLCC Bordeaux, Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Interface Physique et Chimie pour le Vivant ( IPCV ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire de Physique Corpusculaire - Clermont-Ferrand ( LPC ), and Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Physics, Nuclear and High Energy Physics, [STAT.AP]Statistics [stat]/Applications [stat.AP], Geant4-DNA, [PHYS.PHYS.PHYS-ATOM-PH]Physics [physics]/Physics [physics]/Atomic Physics [physics.atom-ph], Monte Carlo method, Elementary particle, Fermion, Electron, Radius, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 030218 nuclear medicine & medical imaging, Computational physics, 03 medical and health sciences, 0302 clinical medicine, Isotopes of iodine, Liquid water, 030220 oncology & carcinogenesis, S-values, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], SPHERES, Statistical physics, Instrumentation, Monte Carlo, Lepton
Abstract

Monte Carlo simulations of S-values have been carried out with the Geant4-DNA extension of the Geant4 toolkit. The S-values have been simulated for monoenergetic electrons with energies ranging from 0.1 keV up to 20 keV, in liquid water spheres (for four radii, chosen between 10 nm and 1 μm), and for electrons emitted by five isotopes of iodine (131, 132, 133, 134 and 135), in liquid water spheres of varying radius (from 15 μm up to 250 μm). The results have been compared to those obtained from other Monte Carlo codes and from other published data. The use of the Kolmogorov–Smirnov test has allowed confirming the statistical compatibility of all simulation results.

Published
2014
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