1. Potential of breastmilk in stem cell research
- Author
-
Seema Tripathy, Saroj Kumar Das, and Shikha Singh
- Subjects
Pluripotent Stem Cells ,Biomedical Engineering ,Biology ,Regenerative Medicine ,Regenerative medicine ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Immune privilege ,Immunity ,Humans ,Induced pluripotent stem cell ,Mammary Glands, Human ,030222 orthopedics ,Transplantation ,Immunity, Cellular ,Milk, Human ,Multipotent Stem Cells ,Infant, Newborn ,Cell Differentiation ,Cell Biology ,Stem Cell Research ,Cell biology ,Heterogeneous population ,Multipotent Stem Cell ,030221 ophthalmology & optometry ,Stem cell - Abstract
Breastmilk is a dynamic, multi-faceted, and complex fluid containing a plethora of biochemical and cellular components that execute developmental effects or differentiation program, providing nourishment and immunity to newborns. Recently, it was reported that breastmilk contains a heterogeneous population of naive cells, including pluripotent stem cells, multipotent stem cells, immune cells, and non-immune cells. The stem cells derived from breastmilk possess immune privilege and non-tumorigenic properties. Thus, breastmilk may represent an ideal source of stem cells collected by non-perceive procedure than other available sources. Thus, this "maternally originating natural regenerative medicine" may have innumerable applications in clinical biology, cosmetics, and pharmacokinetics. This review describes the efficient integrated cellular system of mammary glands, the impressive stem cell hierarchy of breastmilk, and their possible implications in translational research and therapeutics.
- Published
- 2018