1. Prediction of subtle left ventricular systolic dysfunction in homozygous and heterozygous familial hypercholesterolemia: Genetic analyses and speckle tracking echocardiography study
- Author
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Salih Kilic, Yusuf Cekici, Erhan Saraçoğlu, Mustafa Çetin, Ertan Vuruşkan, Mehmet Kucukosmanoglu, Arafat Yildirim, Irfan Veysel Duzen, and Zülfiye Kuzu
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Apolipoprotein B ,Heart Ventricles ,Speckle tracking echocardiography ,Familial hypercholesterolemia ,030204 cardiovascular system & hematology ,Compound heterozygosity ,Hyperlipoproteinemia Type II ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ejection fraction ,biology ,business.industry ,PCSK9 ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,Heterozygote advantage ,medicine.disease ,030104 developmental biology ,Receptors, LDL ,Echocardiography ,Apolipoprotein B-100 ,Cardiology ,biology.protein ,Female ,Proprotein Convertase 9 ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND AND AIMS Few studies have shown the direct effect of familial hypercholesterolemia (FH) on myocardial systolic function. Studies focused on heterozygote FH patients but not homozygote ones, and they did not perform genetic analyses. We aimed to evaluate all types of patients with FH using the potentially more sensitive speckle tracking echocardiography (STE) technique to identify early left ventricular (LV) dysfunction. METHODS Genetic analyses of patients with FH were conducted for LDL-receptor, PCSK9, and ApoB100. Nine homozygote, two compound heterozygote, and 82 heterozygote FH patients and 85 healthy subjects were prospectively studied. Longitudinal and circumferential strain measurements and conventional echocardiography findings were obtained. RESULTS LV ejection fractions were similar for all (homozygote, heterozygote, and control) groups. The LV average longitudinal strain (aLS) and average circumferential strain (aCS) levels were significantly reduced in the homozygote and heterozygote groups when compared with the controls (for aLS, P = .008 (
- Published
- 2018