1. Incidence of anaphylactic reactions after propofol administration in dogs
- Author
-
Tadashi Sano, Akiyoshi Murakami, Misao Terada, Sadaharu Ono, Tomoko Ishida, and Mamoru Onuma
- Subjects
Male ,Allergy ,040301 veterinary sciences ,Anesthesia, General ,anesthesia ,Immunoglobulin E ,0403 veterinary science ,03 medical and health sciences ,chemistry.chemical_compound ,Dogs ,0302 clinical medicine ,Lecithins ,Animals ,Hypnotics and Sedatives ,Medicine ,Dog Diseases ,Egg Hypersensitivity ,Adverse effect ,Anaphylaxis ,Propofol ,Retrospective Studies ,immunoglobulin-E ,Full Paper ,propofol-induced anaphylaxis ,General Veterinary ,biology ,business.industry ,Incidence ,04 agricultural and veterinary sciences ,Perioperative ,medicine.disease ,histamine ,Soybean Oil ,030228 respiratory system ,chemistry ,Isoflurane ,Anesthesia ,dog ,biology.protein ,Surgery ,Female ,business ,Anesthetics, Intravenous ,Histamine ,medicine.drug - Abstract
Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. Following intravenous administration of propofol, the incidence of anaphylactic reactions and plasma histamine concentrations under general anesthesia maintained with isoflurane throughout surgery were compared between the two groups. The frequency of anaphylactic reactions and plasma histamine concentrations were compared by the chi-square test and Student t-test, respectively. The statistical significance for both tests was set at P
- Published
- 2017