1. Zofenopril or irbesartan plus hydrochlorothiazide in elderly patients with isolated systolic hypertension untreated or uncontrolled by previous treatment: a double-blind, randomized study
- Author
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Marco Bucci, Paolo Calabrò, Elena Popescu, Mircea Vladoianu, Giovanni Q. Villani, Sergio Berra, Stefano Omboni, Pietro Amedeo Modesti, Stefano Taddei, Sergio Ghione, Paolo L. Dessì Fulgheri, Francesco Portaluppi, Valerica G. Velican, Marcello Arca, Octavian Pirvu, Massimo Volpe, Paolo Pozzilli, Modesti, Pietro A, Omboni, Stefano, Taddei, Stefano, Ghione, Sergio, Portaluppi, Francesco, Pozzilli, Paolo, Volpe, Massimo, Arca, Marcello, Calabro', Paolo, Fulgheri, Paolo L. Dessì, Bucci, Marco, Berra, Sergio, Villani, Giovanni Q., Vladoianu, Mircea, Popescu, Elena, Velican, Valerica G., and Pirvu, Octavian
- Subjects
Male ,Captopril ,Physiology ,office blood pressure ,Tetrazoles ,Blood Pressure ,030204 cardiovascular system & hematology ,Essential hypertension ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Hydrochlorothiazide ,zofenopril ,030212 general & internal medicine ,Blood Pressure Monitoring, Ambulatory ,Zofenopril ,Biphenyl compound ,Treatment Outcome ,Hypertension ,Cardiology ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,medicine.drug ,medicine.medical_specialty ,Ambulatory blood pressure ,Systole ,NO ,03 medical and health sciences ,Irbesartan ,Vascular Stiffness ,Double-Blind Method ,Internal medicine ,medicine ,Internal Medicine ,Humans ,Antihypertensive Agents ,Aged ,ambulatory blood pressure monitoring ,essential hypertension ,hydrochlorothiazide ,irbesartan ,business.industry ,Biphenyl Compounds ,medicine.disease ,ambulatory blood pressure monitoring, essential hypertension, hydrochlorothiazide, irbesartan, office blood pressure, zofenopril ,chemistry ,business - Abstract
OBJECTIVE To compare zofenopril + hydrochlorothiazide (Z + H) vs. irbesartan + hydrochlorothiazide (I + H) efficacy on daytime SBP in elderly (>65 years) patients with isolated systolic hypertension (ISH), untreated or uncontrolled by a previous monotherapy. METHODS After a 1-week run-in, 230 ISH patients (office SBP ≥ 140 mmHg and DBP
- Published
- 2015