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1. A chromosome-level assembly of the black tiger shrimp ( Penaeus monodon ) genome facilitates the identification of novel growth-associated genes

Author

Wirulda Pootakham, Kanchana Sittikankaew, Frédéric Tangy, Piroon Jenjaroenpun, Jasper J. Koehorst, Intawat Nookaew, Tanaporn Uengwetwanit, Wanilada Rungrassamee, Peter J. Schaap, Pacharaporn Angthong, Jutatip Khudet, Sopacha Arayamethakorn, Rungnapa Leelatanawit, Duangjai Sangsrakru, Vitor A. P. Martins dos Santos, Thidathip Wongsurawat, Chutima Sonthirod, Nitsara Karoonuthaisiri, National Center for Genetic Engineering and Biotechnology [Thailand] (BIOTEC), National Science and Technology Development Agency [Bangkok] (NSTDA), University of Arkansas for Medical Sciences (UAMS), Shrimp Genetic Improvement Center [Thani, Thailand] (SGIC), National Science and Technology Development Agency [Bangkok] (NSTDA)-National Science and Technology Development Agency [Bangkok] (NSTDA), Department of Agrotechnology and Food Sciences [Wageningen], Wageningen University and Research [Wageningen] (WUR), Génomique virale et vaccination, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This project was funded by National Center for Genetic Engineering and Biotechnology (BIOTEC Platform No. P1651718), TDG Food and Feed program, National Science and Technology Development Agency (No. P1950419) and partially supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 734486 (SAFE-Aqua)., Visiting Professor Program 2019 was awarded to Dr. Intawat Nookaew by the National Science and Technology Development Agency, Thailand., The authors acknowledge NSTDA Supercomputer Center (ThaiSC) for providing HPC resources that have contributed to the research results reported within this paper. We thank Ms. Somjai Wongtripop, Mr. Kaidtisak kaewlok and Shrimp Genetic Improvement Center (SGIC) members, as well as Ms. Sudtida Phuengwas (BIOTEC) for the shrimp sample collection., We acknowledge Zulema Dominguez (University of Arkansas for Medical Sciences, USA) for technical assistance on comparative genome. We are grateful to Prof. Morakot Tanticharoen (NSTDA), Dr. Kanyawim Kirtikara (BIOTEC), Dr. Wonnop Visessanguan (BIOTEC) and Assoc Prof. Skorn Koonawootrittriron (Kasetsart University, Thailand) for their mentorship on the shrimp research programs., and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
growth-associated, [SDV]Life Sciences [q-bio], Sequence assembly, Computational biology, Genome, Penaeus monodon, 03 medical and health sciences, transcriptomics, Hi-C, 14. Life underwater, Black tiger shrimp, genes, Genome size, reference genome, 030304 developmental biology, 2. Zero hunger, Comparative genomics, Whole genome sequencing, PacBio, 0303 health sciences, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, 04 agricultural and veterinary sciences, Genome project, biology.organism_classification, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Reference genome
Abstract

The black tiger shrimp (Penaeus monodon) is one of the most prominent farmed crustacean species with an average annual global production of 0.5 million tons in the last decade. To ensure sustainable and profitable production through genetic selective breeding programs, several research groups have attempted to generate a reference genome using short-read sequencing technology. However, the currently available assemblies lack the contiguity and completeness required for accurate genome annotation due to the highly repetitive nature of the genome and technical difficulty in extracting high-quality, high-molecular weight DNA in this species. Here, we report the first chromosome-level whole-genome assembly of P. monodon. The combination of long-read Pacific Biosciences (PacBio) and long-range Chicago and Hi-C technologies enabled a successful assembly of this first high-quality genome sequence. The final assembly covered 2.39 Gb (92.3% of the estimated genome size) and contained 44 pseudomolecules, corresponding to the haploid chromosome number. Repetitive elements occupied a substantial portion of the assembly (62.5%), highest of the figures reported among crustacean species. The availability of this high-quality genome assembly enabled the identification of novel genes associated with rapid growth in the black tiger shrimp through the comparison of hepatopancreas transcriptome of slow-growing and fast-growing shrimps. The results highlighted several gene groups involved in nutrient metabolism pathways and revealed 67 newly identified growth-associated genes. Our high-quality genome assembly provides an invaluable resource for accelerating the development of improved shrimp strain in breeding programs and future studies on gene regulations and comparative genomics.

Published
2020

2. How many large camelids in the world? A synthetic analysis of the world camel demographic changes

Author

Bernard Faye, Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Al-Farabi Kazakh National University [Almaty] (KazNU), Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and This paper is supported by the PRIMA programme under grant agreement No1832, project 'Boost the production, processing and consumption of camel milk in the Mediterranean basin (CAMELMILK)'. The PRIMA programme is supported by the European Union. We acknowledge also Mrs. Mohammed Bengoumi and Thomas Schultze for proofreading the English version.

Subjects
L01 - Elevage - Considérations générales, Census, 040301 veterinary sciences, [SDV]Life Sciences [q-bio], Applied ecology, Population, Dromadaire, Chameau, Distribution des populations, Dromedary, Tropical livestock unit, 0403 veterinary science, Camel population, International database, Secession, Dynamique des populations, Population animale, education, Socioeconomics, Camelidae, Demography, lcsh:SF1-1100, education.field_of_study, biology, business.industry, 0402 animal and dairy science, L60 - Taxonomie et géographie animales, 04 agricultural and veterinary sciences, Chameau d'asie, biology.organism_classification, 040201 dairy & animal science, FAO, Geography, Agriculture, Animal Science and Zoology, Livestock, lcsh:Animal culture, business, Camelid, Bactrian
Abstract

At world level, the current official number of large camelids cannot be determined exactly (it is estimated to be more than 35 million heads), and the role of camels in the livestock economy is highly variable. The only reliable statistics are provided by FAO since 1961. According to these data, five different patterns of demographic changes have been observed. In countries marked by a regular or drastic decline of their camelid population, a tendency to re-increase has been in force since the beginning of the century, except in India. Generally, countries marked by a sharp recent increase in their large camelid population have implemented a census and readjusted their data. Many inconsistencies occur in available data, most notably cases arising from changes occurring in state status (for example secession of Eritrea, Soviet Union collapse). Moreover, large camelid stocks in Australia, in countries of new camel establishment (Western countries) and those related to the expansion of camel farming, notably in Africa, are not recorded in the international database. In addition, there is no distinction between dromedary and Bactrian data. The present large camelid population in the world is probably more than 40 million and could reach 60 million after 25 years from now if the current demographic trend is maintained.

Published
2020

3. Combining Analytical Approaches and Multiple Sources of Information to Improve Interpretation of Diagnostic Test Results for Tuberculosis in Wild Meerkats

Author

Stuart J. Patterson, Charlene Clarke, Tim H. Clutton-Brock, Michele A. Miller, Sven D. C. Parsons, Dirk U. Pfeiffer, Timothée Vergne, Julian A. Drewe, Patterson, Stuart J [0000-0002-4907-8373], Clarke, Charlene [0000-0002-9497-2614], Miller, Michele A [0000-0002-5883-6076], Parsons, Sven DC [0000-0002-9033-9686], Pfeiffer, Dirk U [0000-0001-7000-0530], Drewe, Julian A [0000-0003-0709-8066], Apollo - University of Cambridge Repository, Veterinary Epidemiology, Economics and Public Health Group, Royal Veterinary College, SAMRC Centre for TB Research, Stellenbosch University, Mammal Research Institute, Department of Zoology and Entomology [Pretoria], University of Pretoria [South Africa]-University of Pretoria [South Africa], Large Animal Research Group, University of Cambridge [UK] (CAM), Department of Infectious Diseases and Public Health, City University of Hong Kong [Hong Kong] (CUHK), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This paper has relied on records of individual identities and life histories maintained by the Kalahari Meerkat Project, which is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 294494), the Human Frontier Science Program (funding reference RGP0051/2017), the University of Zurich, the Swiss National Science Foundation and the Mammal Research Institute at the University of Pretoria, South Africa. This specific work was funded by BBSRC (training scholarship BB/F016891/1), the Royal Veterinary College and the Friends of the Kalahari Meerkat Project, kalahari-meerkats.com/fkmp. Thanks also to Irene Staehelin for her generous support. This research was funded partially by the South African government through the South African Medical Research Council and the National Research Foundation South African Research Chair Initiative (Grant #86949). MM, CC, and SP were supported by the South African government through the South African Medical Research Council and the National Research Foundation Chair Initiative (grant #86949)., and European Project: 294494,EC:FP7:ERC,ERC-2011-ADG_20110310,THCB2011(2012)

Subjects
General Veterinary, 040301 veterinary sciences, [SDV]Life Sciences [q-bio], wildlife, Veterinary medicine, diagnostics, interpretation, tuberculosis, meerkats, 04 agricultural and veterinary sciences, 01 natural sciences, Article, 3. Good health, 0403 veterinary science, 010104 statistics & probability, QL1-991, SF600-1100, Animal Science and Zoology, 0101 mathematics, Zoology
Abstract

Data presented in this study is publicly available at https://figshare.com/s/45bd5369a97b4c2489bf (accessed on 25 October 2021).Ethical permission for the study was provided by the University of Pretoria (ECO20-14), and this manuscript has been approved for publication by the Royal Veterinary College (PPS_01715). Permission to carry out research in the region was granted by the Northern Cape Department of Environment and Nature Conservation.; International audience; Simple SummaryDiagnostic tests used in animals are ideally extensively trialled to ensure that practitioners have confidence in the results; the ideal target should be 100% of infected animals testing positive (sensitivity), and 100% of uninfected animals testing negative (specificity). In these trials, a gold standard is necessary, against which the diagnostic tests may be compared. Commonly, tests of wild animals are not extensively trialled due to shortages of samples and the rarity of gold standard tests. This study uses samples collected for the purpose of diagnosing Mycobacterium suricattae infection in meerkats and estimates the sensitivity and specificity of available tests, both individually, and in combination. A small number of post-mortems (gold standard) were carried out, providing definitive evidence of infected animals against which to compare the tests. In addition, test results were unconventionally compared to survival times and clinical characteristics, aiming to quantify the prognostic capabilities of the tests. The study therefore not only estimates the required parameters against which to assess these tests, but also provides a model for future assessment of diagnostic tests in imperfect field scenarios. Wildlife diseases are increasingly recognised as important to society, and so methods to better quantify these are increasingly important.AbstractDiagnostic tests are used to classify individual animals’ infection statuses. However, validating test performance in wild animals without gold standard tests is extremely challenging, and the issue is further complicated in chronic conditions where measured immune parameters vary over time. Here, we demonstrate the value of combining evidence from different diagnostic approaches to aid interpretation in the absence of gold standards, large sample sizes, and controlled environments. Over a two-year period, we sampled 268 free-living meerkats (Suricata suricatta) longitudinally for Mycobacterium suricattae (a causative agent of tuberculosis), using three ante-mortem diagnostic tests based on mycobacterial culture, and antigen-specific humoral and cell-mediated immune responses, interpreting results both independently and in combination. Post-mortem cultures confirmed M. suricattae infection in 22 animals, which had prior ante-mortem information, 59% (13/22) of which were test-positive on a parallel test interpretation (PTI) of the three ante-mortem diagnostic assays (95% confidence interval: 37–79%). A similar ability to detect infection, 65.7% (95% credible interval: 42.7–84.7%), was estimated using a Bayesian approach to examine PTI. Strong evidence was found for a near doubling of the hazard of death (Hazard Ratio 1.75, CI: 1.14–2.67, p = 0.01), associated with a positive PTI result, thus demonstrating that these test results are related to disease outcomes. For individual tests, small sample sizes led to wide confidence intervals, but replication of conclusions, using different methods, increased our confidence in these results. This study demonstrates that combining multiple methodologies to evaluate diagnostic tests in free-ranging wildlife populations can be a useful approach for exploiting such valuable datasets.

Published
2021

4. Expertise-based decision support for managing food quality in agri-food companies

Author

Clément Sipieter, Bernard Cuq, Jérôme Fortin, Patrice Buche, Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre National de la Recherche Scientifique (CNRS), Graphs for Inferences on Knowledge (GRAPHIK), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), The research leading to these results has received partial fundingfrom the CASDAR Docamex Programme from the French Ministry ofAgriculture (2016–2020). It has also benefited from preliminary worksperformed during one project with the Technical Centre of Cheeses inPoligny (CTFC) and two projects with French industrial partners. Theauthors would also like to thank the CTFC, who authorized us to presentin this paper some of the knowledge provided by their technical expertsand extracted from their knowledge base., Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
0106 biological sciences, Decision support system, Knowledge management, Computer science, Interface (Java), Knowledge Acquisition and Representation, Horticulture, Decision support systems, 01 natural sciences, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], [INFO]Computer Science [cs], 2. Zero hunger, Functional specification, business.industry, Core ontology, Forestry, 04 agricultural and veterinary sciences, Computer Science Applications, Knowledge base, Conceptual graphs, Conceptual graph, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Mind map, Graph (abstract data type), business, Knowlegde extraction, Agronomy and Crop Science, 010606 plant biology & botany
Abstract

International audience; In many agri-food companies, food quality is often managed using expertise gained through experience. Overall quality enhancement may come from sharing collective expertise. In this paper, we describe the design and implementation of a complete methodology allowing an expert knowledge base to be created and used to recommend the technical action to take to maintain food quality. We present its functional specifications, defined in cooperation with several industrial partners and technical centres over the course of several projects carried out in recent years. We propose a systematic methodology for collecting the knowledge on a given food process, from the design of a questionnaire to the synthesis of the information from completed questionnaires using a mind map approach. We then propose an original core ontology for structuring knowledge as possible causal relationships between situations of interest. We describe how mind map files generated by mind map tools are automatically imported into a conceptual graph knowledge base, before being validated and finally automatically processed in a graph-based visual tool. A specific end-user interface has been designed to ensure that end-user experts in agri-food companies can use the tool in a convenient way. Finally, our approach is compared with current research.

Published
2019

5. Measuring Skewness Premia

Author

Hugues Langlois, Ecole des Hautes Etudes Commerciales (HEC Paris), and HEC Research Paper Series

Subjects
Economics and Econometrics, Strategy and Management, Risk premium, forecasting, Momentum (finance), Accounting, 0502 economics and business, Econometrics, Economics, Downside beta, coskewness, Stock (geology), 040101 forestry, 050208 finance, Ex-ante, Systematic skewness, 05 social sciences, Contrast (statistics), Skewness risk, 04 agricultural and veterinary sciences, Coskewness, Skewness, idiosyncratic skewness, [SHS.GESTION]Humanities and Social Sciences/Business administration, 0401 agriculture, forestry, and fisheries, Profitability index, large panel regression, JEL: G - Financial Economics/G.G1 - General Financial Markets/G.G1.G12 - Asset Pricing • Trading Volume • Bond Interest Rates, Finance
Abstract

We provide a new methodology to empirically investigate the respective roles of systematic and idiosyncratic skewness in explaining expected stock returns. Using a large number of predictors, we forecast the cross-sectional ranks of systematic and idiosyncratic skewness which are easier to predict than their actual values. Compared to other measures of ex ante systematic skewness, our forecasts create a significant spread in ex post systematic skewness. A predicted systematic skewness risk factor carries a significant risk premium that ranges from 7% to 12% per year and is robust to the inclusion of downside beta, size, value, momentum, profitability, and investment factors. In contrast to systematic skewness, the role of idiosyncratic skewness in pricing stocks is less robust. Finally, we document how the determinants of systematic and idiosyncratic skewness differ.

Published
2018

6. CAPM-Based Company (Mis)valuations

Author

Olivier Dessaint, Jacques Olivier, David Thesmar, Clemens A. Otto, Haldemann, Antoine, Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS), and HEC Paris Research Paper

Subjects
Economics and Econometrics, Valuation effects, Mergers and Acquisitions, JEL: G - Financial Economics/G.G3 - Corporate Finance and Governance/G.G3.G31 - Capital Budgeting • Fixed Investment and Inventory Studies • Capacity, JEL: G - Financial Economics, Capital budgeting, JEL: G - Financial Economics/G.G3 - Corporate Finance and Governance/G.G3.G34 - Mergers • Acquisitions • Restructuring • Corporate Governance, Accounting, Capital Asset Pricing Model, 0502 economics and business, Mergers and acquisitions, Economics, Econometrics, Capital asset pricing model, Beta (finance), Valuation (finance), 040101 forestry, Capital Budgeting, 050208 finance, 05 social sciences, 04 agricultural and veterinary sciences, Valuation, Value (economics), [SHS.GESTION]Humanities and Social Sciences/Business administration, 0401 agriculture, forestry, and fisheries, [SHS.GESTION] Humanities and Social Sciences/Business administration, Finance
Abstract

© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. There is a discrepancy between CAPM-implied and realized returns. Using the CAPM in capital budgeting - as recommended in textbooks - should thus have real effects. For instance, low beta projects should be valued more by CAPM users than by the market. We test this hypothesis using M&A data and show that bids for low-beta private targets entail lower bidder returns. We provide further support by testing several ancillary predictions. Our analyses suggest that using the CAPM when valuing targets leads to valuation errors (relative to the market's view) corresponding on average to 12% to 33% of the deal values.

Published
2018

7. Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L's leaf: In vitro and in vivo approach

Author

Mohamed Bouaziz, Mohamed Makni, Naziha Marrakchi, Bassem Khemakhem, M Chakroun, Hazem Ben Mabrouk, Noureddine Drira, Hanen El Abed, Hafedh Mejdoub, Faculté des Sciences de Sfax, Université de Sfax - University of Sfax, University of Gabes, Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), École Nationale d'Ingénieurs de Sfax | National School of Engineers of Sfax (ENIS), and The major part of this work was accomplished at the Faculty of Sciences of Sfax. The authors would like to thank Prof. Monique Simmonds from Jodrell Laboratory, Kew Gardens UK, for her help with LC–MS/MS analysis. Special thanks are also go to Pr. Hafedh Bejaoui, from the English department at the Faculty of Science of Sfax and to Sana Chakroun (Rudolf-Bultmann Str. 4. 35039 Marburg) for carefully proofreading and polishing the language of the present paper, to Zaineb Kammoun (Sfax Faculty of Science) for her invaluable assistance in this project.

Subjects
0301 basic medicine, Male, MESH: Polyphenols/pharmacology, MESH: Plant Extracts/pharmacology, [SDV]Life Sciences [q-bio], Flavonoid, Phytochemicals, Pharmacology, MESH: Hyperglycemia/complications, MESH: Plant Leaves/chemistry, Mice, Oral administration, Tandem Mass Spectrometry, inhibitors, MESH: Hypoglycemic Agents/pharmacology, MESH: Phytochemicals/pharmacology, MESH: Animals, α-Glucosidase and α-Amylase, Acarbose, chemistry.chemical_classification, Cell Death, MESH: Antineoplastic Agents/pharmacology, MESH: Polyphenols/therapeutic use, Phoeniceae, 04 agricultural and veterinary sciences, General Medicine, MESH: Hyperglycemia/drug therapy, Postprandial Period, 040401 food science, Postprandial, Biochemistry, MESH: Phytotherapy, MESH: Hypoglycemic Agents/therapeutic use, MESH: Postprandial Period, MESH: Antineoplastic Agents/therapeutic use, medicine.drug, LC–MS/MS analysis, MESH: Phoeniceae/chemistry, MESH: Cell Line, Tumor, MESH: Phytochemicals/therapeutic use, MESH: Diabetes Mellitus, Experimental/complications, MESH: Diabetes Mellitus, Experimental/drug therapy, Antineoplastic Agents, MESH: alpha-Amylases/metabolism, Diabetes Mellitus, Experimental, 03 medical and health sciences, 0404 agricultural biotechnology, In vivo, MESH: Enzyme Assays, Diabetes mellitus, Cell Line, Tumor, medicine, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Animals, Humans, Hypoglycemic Agents, MTT assay, IC50, MESH: Mice, Enzyme Assays, MESH: Plant Extracts/therapeutic use, MESH: Humans, Cytotoxic activity, Plant Extracts, MESH: Tandem Mass Spectrometry, Polyphenols, alpha-Glucosidases, medicine.disease, IGR-39 cancer cell lines, MESH: Diabetes Mellitus, Type 2/drug therapy, Phoenix dactylifera L.’s leaves, MESH: Male, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, MESH: Cell Death/drug effects, MESH: Diabetes Mellitus, Type 2/complications, Plant Leaves, 030104 developmental biology, Antidiabetic activity, chemistry, Diabetes Mellitus, Type 2, Hyperglycemia, alpha-Amylases, MESH: alpha-Glucosidases/metabolism, MESH: Chromatography, Liquid, Chromatography, Liquid, Phytotherapy
Abstract

International audience; Among various chronic disorders, cancer and diabetes mellitus are the most common disorders. This study was designed to evaluate the effectiveness of hydroalcoholic extract of Phoenix dactylifera L. leaves (HEPdL) in animal models of type II diabetes in vitro/in vivo and in a human melanoma-derived cell line (IGR-39). A liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis was also performed to determine the amount of phenolic and flavonoid compounds in this plant. The physicochemical results by LC–MS/MS analysis of HEPdL showed the presence of 10 phenolic compounds. The in vitro study showed that the extract exhibited a more specific and potent inhibitor of α-glucosidase than α-amylase with an IC50 value of 20 ± 1 μg/mL and 30 ± 0.8 μg/mL, respectively. More importantly, the in vivo study of the postprandial hyperglycemia activity with (20 mg/kg) of HEPdL showed a decrease in plasma glucose levels after 60 min in resemblance to the glucor (acarbose) (50 mg/kg) effect. The oral administration of HEPdL (20 mg/kg) in alloxan-induced diabetic mices for 28 days showed a more significant anti-diabetic activity than that of the drug (50 mg/kg). Moreover, cytotoxicity effects of HEPdL in IGR-39 cancer cell lines were tested by MTT assay. This extract was effective in inhibiting cancer cells growth (IGR-39) at dose 35 and 75 μg/mL. These results confirm ethnopharmacological significance of the plant and could be taken further for the development of an effective pharmaceutical drug against diabetes and cancer

Published
2016

8. The Competitive Effect of a Bank Megamerger on Credit Supply

Author

Henri Fraisse, Johan Hombert, Mathias Lé, Haldemann, Antoine, Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS), and HEC Research Paper Series

Subjects
Economics and Econometrics, Exploit, JEL: L - Industrial Organization/L.L1 - Market Structure, Firm Strategy, and Market Performance/L.L1.L13 - Oligopoly and Other Imperfect Markets, Financial system, Banking competition, Monetary economics, Bank megamerger, Competition (economics), Bank credit, JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G21 - Banks • Depository Institutions • Micro Finance Institutions • Mortgages, Credit history, 0502 economics and business, 040101 forestry, 050208 finance, Merger, 05 social sciences, 04 agricultural and veterinary sciences, Start up, Investment (macroeconomics), Credit Supply, 0401 agriculture, forestry, and fisheries, Bond market, [SHS.GESTION]Humanities and Social Sciences/Business administration, Credit crunch, Business, Credit valuation adjustment, [SHS.GESTION] Humanities and Social Sciences/Business administration, Finance
Abstract

We examine how the merger between two European megabanks affects credit supply to small and medium-sized businesses. Using loan-level and firm-level data, we exploit variation in the merging banks' market overlap to identify the competition effect of the merger. We find that the merged bank decreases the supply of credit to existing firms and new firms. This effect is not offset by other banks increasing their lending, leading to an overall decline in bank credit. This reduction in credit supply is associated with higher firm exit. However, for continuing firms, the merger has no adverse effects on investment and employment.

Published
2016

9. Stability and bioaccessibility of anthocyanins in bakery products enriched with anthocyanins

Author

Sibel Karakaya, Marisa Sanz-Buenhombre, Sebnem Simsek, Adrienn Hegyi, Sedef Nehir El, Blanca Viadel, Didier Dupont, Beatriz Pérez, Alberto Guadarrama Rodriguez, Zsófia Kertész, Alper Tolga Eker, Carlos Pineda-Vadillo, Alessandra Bordoni, Karakaya, Sibel, Simsek, Sebnem, Eker, Alper Tolga, Pineda Vadillo, Carlo, Dupont, Didier, Perez, Beatriz, Viadel, Blanca, Sanz Buenhombre, Marisa, Rodriguez, Alberto Guadarrama, Kertész, Zsófia, Hegyi, Adrienn, Bordoni, Alessandra, Sedef Nehir, El, Department of Food Engineering, Nutrition Section, Ege university, Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Ainia Technology Center, Technology Park of Valencia, AbroBiotec S.L. Ctra. San Bernardo S/N. 47359, Valbuena de Duero, Campden BRI Hungary Ltd, Alma Mater Studiorum University of Bologna (UNIBO), European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 311876: Fig. 2 Retention of AC stored 21 days at room temperature and −20 °C. Bun RT: bun stored at room temperature, Bun F: bun stored at −20 °C, biscuit RT: biscuit stored at room temperature, biscuit F: biscuit stored at −20 °C. a–c Different letters in the same group represent statistical differences (p < 0.05). Paper Food & Function Food Funct. This journal is © The Royal Society of Chemistry 2016 Published on 04 July 2016. Downloaded by Ege Universitesi on 25/07/2016 11:58:24. View Article Online PATHWAY-27 (Pivotal assessment of the effects of bioactives on health and wellbeing. From human genome to food industry). Eminol® composition analyses were performed by the Plateforme Polyphénols INRA UMR-SPO in Montpellier (France)., and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
Taste, digestion, cyanin, human health, Anthocyanins, Matrix (chemical analysis), chemistry.chemical_compound, Glucosides, Functional Food, Salmonella, Surveys and Questionnaires, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Vitis, Cooking, Food science, bioaccessibilité, complément alimentaire, 2. Zero hunger, anthocyane, Chemistry, Bread, 04 agricultural and veterinary sciences, General Medicine, santé humaine, 040401 food science, Malvidin, bakery, Docosahexaenoic acid, Food, Fortified, Docosahexaenoic Acids, Food storage, Biological Availability, Food Contamination, produit de boulangerie, polyphénol, 0404 agricultural biotechnology, compléméntation, Escherichia coli, Food microbiology, Plant Extracts, Polyphenols, Consumer Behavior, Listeria monocytogenes, Anthocyanins, bakery products, flavonoids, sensory perception, Food Storage, Polyphenol, Anthocyanin, Food Microbiology, boulangerie, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Food Analysis, Food Science
Abstract

Anthocyanins, water soluble polyphenols, have been associated with several beneficial health effects. The aim of this study was to determine how the baking process and food matrix affect anthocyanin stability and bioaccessibility in bakery products in order to develop functional foods. Three well known regularly consumed bakery products (buns, breadsticks and biscuits) were enriched with anthocyanin (AC) isolated from grape skin alone or in combination with docosahexaenoic acid (AC + DHA) to reveal knowledge on AC as active ingredients in real food systems rather than pure compounds. Anthocyanin amounts added to the formulations of buns, breadsticks and biscuits were 34 mg per 100 g, 40 mg per 100 g and 37 mg per 100 g, respectively. The effect of processing, storage and the food matrix on AC stability and bioaccessibility was investigated. In addition, the sensory properties of bakery products were evaluated. Breadsticks enriched with AC and AC + DHA received the lowest scores in the pre-screening sensory test. Therefore breadsticks were excluded from further analysis. AC retentions, which were monitored by determination of malvidin 3-O-glucoside, in the bun and biscuit after baking were 95.9% (13.6 mg per 100 g) and 98.6% (15.2 mg per 100 g), respectively. Biscuits and buns enriched only with AC showed significantly higher anthocyanin bioaccessibilities (57.26% and 57.30%, respectively) than the same ones enriched with AC + DHA. AC stability in enriched products stored for 21 days was significantly lower than in products stored for 7 days (p < 0.05). However, this loss can be accepted as negligible since more than 70% of AC was retained in all the products.

Published
2016

10. Comparative analysis of thermally modified and native spruce loaded perpendicular to the grain

Author

Beate Buchelt, Alexander Pfriem, Mario Zauer, André Wagenführ, Institute of Wood and Paper Technology, and Technische Universität Dresden = Dresden University of Technology (TU Dresden)

Subjects
040101 forestry, 0106 biological sciences, Materials science, Scanning electron microscope, Forestry, 04 agricultural and veterinary sciences, Bending, Thermal treatment, 01 natural sciences, Radial direction, Brittleness, Flexural strength, 010608 biotechnology, Physical Sciences, Perpendicular, Fracture (geology), 0401 agriculture, forestry, and fisheries, General Materials Science, Composite material
Abstract

International audience; The aim of this work was to analyse the material behaviour of thermally modified and native spruce by load applied perpendicularly to the grain. Therefore, thermally modified and native samples were prepared for bending tests with the load in tangential direction. The bending strength in radial direction decreases significantly with the thermal treatment. The fracture surfaces in the tangential section of the bending samples after testing were analysed with a scanning electron microscope. For native samples, the typical failure was found in the intercellular area. For thermally modified samples, failure of the entire cell wall was observed. The material behaviour is more brittle, as demonstrated by the load-deflection curves, but also by anatomical studies of the fracture surfaces.

Published
2010

11. Toxicity potential in the extraneous compounds of white mulberry wood (Morus alba)

Author

Aida Se Golpayegani, Eric Masson, Joseph Gril, Kambiz Pourtahmasi, Marie-France Thévenon, Laboratoire de Mécanique et Génie Civil (LMGC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Bois (BOIS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), BioWooEB (UPR BioWooEB), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Centre Régional d'Innovation et de Transferts Technologiques des industries du bois (CRITT Bois), CRITT Bois, Department of Wood and Paper Science and Technology, and University of Tehran

Subjects
0106 biological sciences, K50 - Technologie des produits forestiers, Manufactures, Musical instrument, Resorcinol, gc-mass, 01 natural sciences, Industrial and Manufacturing Engineering, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, Health problems, Reticulitermes, extractives, Chemical Engineering (miscellaneous), Organic chemistry, decay resistance, biology, Forestry, 04 agricultural and veterinary sciences, Morus alba, Solvent, Toxicity, Extraction par solvant, White mulberry, P02 - Pollution, resorcinols [EN], food.ingredient, Materials Science (miscellaneous), TS1-2301, white mulberry, Reticulitermes flavipes, food, Toxicité, Phenols, 040101 forestry, Chromatographie en phase gazeuse, toxicity, SD1-669.5, biology.organism_classification, 010602 entomology, White Mulberry, GC-mass, chemistry, 0401 agriculture, forestry, and fisheries
Abstract

International audience; The health problems amongst musical instrument makers working on the White mulberry (Morus alba), lead to investigate the toxicity potential of wood extractives. Five solvents of different polarity and two methods of extractions were used to ensure a thorough, clear and classified compound removal. The compounds were identified using qualitative GC-mass and the toxicity were determined by studying their effect on termite survival (Reticulitermes flavipes). The results indicated the presence of different compound categories like phenols, higher hydrocarbons, fatty acids, sterols and aromatic components in the extractives. These compounds were not removable by just one solvent and the order of removal was polarity related. The extractives were found toxic towards termites. Resorcinol, which corresponded to the highest proportion of peaks in the GC-mass spectra, has been assigned as the possible compound responsible for the allergic reactions by the artisans.

Published
2014

12. Eucalyptus and Acacia tree growth over entire rotation in single- and mixed-species plantations across five sites in Brazil and Congo

Author

Maureen Voigtlaender, Florence Tardy, Louis Mareschal, Philippe Deleporte, Daniel Epron, Joseph Levillain, Jean-Paul Laclau, José Leonardo de Moraes Gonçalves, Yann Nouvellon, André Mabiala, José Luis Gava, Jean-Pierre Bouillet, Fernando Palha Leite, Rodrigo Hakamada, Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA), Dept Ciencias Florestais, University of São Paulo (USP), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Escola Superior de Agricultura 'Luiz de Queiroz' (ESALQ), Universidade de São Paulo (USP), Dept Forest Sci, ESALQ USP, International Paper do Brasil, Centre de Recherche sur la Durabilité et la Productivité des Plantations Industrielles (CRDPI), Laboratoire de Lyon [ANSES], Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Systèmes de Cultures Bananes, Ananas, et Plantains (Cirad-FLHOR-UPR 26 Systèmes bananes et ananas), Département Productions fruitières et horticoles (FLHOR), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] (EEF), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Institut National de la Recherche Agronomique (INRA)-Institut de Recherche pour le Développement (IRD)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), and Laboratoire de Lyon

Subjects
0106 biological sciences, F08 - Systèmes et modes de culture, Humid subtropical climate, F62 - Physiologie végétale - Croissance et développement, Complementarity, Facteur climatique, 01 natural sciences, Nutrient, Acacia mangium, media_common, Biomass (ecology), Eucalyptus, biology, Wood production, Forestry, 04 agricultural and veterinary sciences, Plantation forestière, Facteur édaphique, Rendement des cultures, Facilitation, F40 - Écologie végétale, Interaction, media_common.quotation_subject, Acacia, Management, Monitoring, Policy and Law, Competition (biology), Culture en mélange, Botany, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Croissance, Nature and Landscape Conservation, Competition, Mixed-species plantations, 15. Life on land, biology.organism_classification, K10 - Production forestière, Agronomy, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Système de culture, 010606 plant biology & botany
Abstract

International audience; The association of N-2-fixing species (NFS) could be an attractive option for achieving a sustainable increase of Eucalyptus plantations (EP) productivity through a positive balance between facilitative effects and competition between species. A randomised block design was replicated at four sites (Cenibra, USP, Suzano and IP) in Southern Brazil and at one site in Congo. The development of mono-specific stands of Acacia mangium (100A) and Eucalyptus grandis or urophylla x grandis (100E), was compared with N fertilisation treatment (100E + N) and with mixed-species plantations in a 1:1 ratio (50A:50E), and in an additive series with varying densities of acacia for the same density of eucalypt (25A:100E, 50A:100E, 100A:100E). The objectives were to assess the effect of mixtures on tree growth and stand production, and the behaviour of the two species in contrasting soil and climatic conditions. Tree growth was monitored over stand rotation and the biomass of aboveground tree components estimated at mid-rotation and at harvesting age. Eucalyptus height was 13% higher in Brazil than in Congo. Favourable ecological conditions in Congo and Cenibra led to 50% higher Acacia tree height than at the other sites. A depressive effect of Eucalyptus neighbour trees on Acacia height and circumference growth, lower in Congo than in Brazil, was observed in the mixtures from age 1-2 years onwards. Depressive effects of acacia on eucalypt height and circumference growth were low in USP, Suzano and IP, high in Cenibra, and not observed in Congo, in 50A:50E and 25A:100E. A positive though insignificant response to N fertilisation was only found in USP and Congo. Complementarity for light and soil resource capture between Eucalyptus and Acacia trees resulted in mean annual increments in total stand stemwood biomass (MAI) that were 7-15%, 6-12%, and 40% higher in the additive series than for 100E in Cenibra, LISP and Congo, respectively at mid-rotation. Whilst lasting complementarity and facilitation in Congo led to 17-34% higher MAI in mixtures than for 100E at harvesting age, MAIs were not significantly higher in mixtures than for 100E in Brazil. Mixed-species plantations of Eucalyptus and A. mangium might enhance aboveground stand production on poor nutrient soils in warm and humid tropical climates with low water limitations

Published
2013

13. Effect of extractions on dynamic mechanical properties of white mulberry (Morus alba)

Author

Marie-France Thévenon, Kambiz Pourtahmasi, Iris Brémaud, Olivier Arnould, Joseph Gril, Aida Se Golpayegani, Mécanique de l'Arbre et du Bois ( MAB ), Laboratoire de Mécanique et Génie Civil ( LMGC ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Production et valorisation des bois tropicaux ( Bois tropicaux ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ), Department of Wood and Paper Science and Technology, University of Tehran, Mécanique de l'Arbre et du Bois (MAB), Laboratoire de Mécanique et Génie Civil (LMGC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Production et valorisation des bois tropicaux (UPR Bois tropicaux), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)

Subjects
K50 - Technologie des produits forestiers, 0106 biological sciences, food.ingredient, Yield (engineering), white mulberry wood (Morus alba L.), Modulus, anisotropy, DMA, F50 - Anatomie et morphologie des plantes, Vibration, 01 natural sciences, [PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], Biomaterials, Bois, food, 010608 biotechnology, extractives, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], Composite material, Anisotropy, 040101 forestry, Specific modulus, Chemistry, Extraction (chemistry), 04 agricultural and veterinary sciences, Dynamic mechanical analysis, Propriété acoustique, Morus alba, damping coefficient, White Mulberry, Propriété mécanique, [ SPI.MECA.MEMA ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], [ PHYS.MECA.MEMA ] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], vibrational properties, 0401 agriculture, forestry, and fisheries, Dissipation factor
Abstract

Vibrational properties of wood are affected by several parameters, of which extractives can be one of the most important ones. Wood for European musical instruments has been often studied, but traditional Middle Eastern ones had been left unnoticed. In this study white mulberry (Morus alba L.), the main material for long-necked lutes in Iran, was extracted by five solvents of various polarities (water included). Free-free bar forced vibrations were used to measure longitudinal (L) loss tangent (tanδ), storage (elastic) modulus (E′) and specific modulus (E′/γ) in the acoustic range. Their anisotropy between the 3 axes of orthotropy was determined by dynamic mechanical analysis. Native wood had a quite low E L′/γ but its tanδ was smaller than expected, and the anisotropy of tanδ and E′/γ was very low. Removal of extractives caused tanδ to increase and moduli to decrease. Acetone, the most effective solvent on damping despite a moderate extraction yield, increased tanδ L by at least 20% but did not modify E′/γ as much. When used successively, its effects masked those of solvents used afterwards. Anisotropy of E′/γ was nearly unchanged after extraction in methanol or hot water, while tanδ was much more increased in R than in T direction. Results suggest that in white mulberry, damping is governed more by nature and localization of extractives rather than by their crud abundance.

Published
2012

14. Classification and mapping of anthropogenic landforms on cultivated hillslopes using DEMs and soil thickness data - Example from the SW Parisian Basin, France

Author

Sébastien Salvador-Blanes, Florent Hinschberger, Jean-Jacques Macaire, Hocine Bourennane, Caroline Chartin, Transferts continentaux : forçages anthropiques, climatiques et géodynamiques, Institut des Sciences de la Terre d'Orléans (ISTO), Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité de Science du Sol, Institut National de la Recherche Agronomique (INRA), Université de Tours (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Financial support provided by the ANR (Agence Nationale de la Recherche) VMCS project LANDSOIL is gratefully acknowledged. The authors would like to thank Jean-Paul Bakyono and Isabel Pene-Galland for data collection in the field. This paper was much improved thanks to the comments of Peter Houben and an anonymous referee and thanks to Lauren Valverde who revised my english style., and Chartin, Caroline

Subjects
010504 meteorology & atmospheric sciences, Soil test, Morphometric attributes, [SDE.MCG]Environmental Sciences/Global Changes, Digital Elevation Model, Structural basin, bassin parisien, Spatial distribution, 01 natural sciences, Field borders, Lynchet, Digital elevation model, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Geomorphology, 0105 earth and related environmental sciences, Earth-Surface Processes, geography, geography.geographical_feature_category, Landform, anthropogenic landform, predictive modelling, parisian basin, modèle numérique de terrain, attribut morphométrique, épaisseur du sol, banquette, parcellaire, arbre de classification, digital elevation model, morphometric attribute, soil thickness, lynchet, field border, classification tree, relief anthropique, modélisation prédictive, physical, geosciences, multidisciplinary, geology, 04 agricultural and veterinary sciences, 15. Life on land, Current (stream), 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Spatial variability, Classification Tree, Geology, Soil thickness
Abstract

International audience; This study focuses on linear anthropogenic landforms of decametric width on cultivated hillslopes and their relations to soil thickness variability. The 16 ha study area shows a rolling topography supported by Cretaceous chalk of the SW Parisian Basin, France. Two types of landforms were identified: lynchets, similar to those described as soil terraces occurring on downslope field parts in other contexts, and undulations, linear, convex landforms that cut across fields. Accurate DEM construction and a detailed soil thickness survey were performed all over the study area. Soil samples were classified considering their location on specific types of anthropogenic landforms. The classification tree (CT) method was applied to assess whether lynchets and undulations can be discriminated through morphometric attributes (slope, curvature, profile curvature and planform curvature) and soil thickness (CTsoil) or through morphometric attributes only (CTtopo). The CT application establishes predictive classification models to map the spatial distribution of lynchets and undulations over the whole study area. The validation results of the CTsoil and CTtopo applications show model efficiencies of 83% and 67%, respectively. Both models performed well for lynchets. Errors arise mainly from difficulties in unequivocally discriminating gently convex undulations and undifferentiated surfaces, especially when soil thickness is not accounted for. Mean values of soil thickness are 1.08, 0.62 and 0.45 m in lynchets, undulations and undifferentiated areas, respectively. The general shape of the thickened soil is characteristic to each type of anthropogenic landform. Multi-temporal mapping of field border networks shows that undulations are linked to borders that were removed during the latest land consolidation. Lynchets are associated with current field borders. Lynchets and undulations, which cover 39% of the study area, define topographic indicators of human-induced soil accumulations. The method involves perspectives for efficiently mapping and quantifying the anthropogenically modified spatial variability of soil thickness on agricultural hillsides.

Published
2011

15. Availability of essential amino acids, nutrient utilisation and growth in juvenile black tiger shrimp, Penaeus monodon, following fishmeal replacement by plant protein

Author

Sadasivam Kaushik, Vincent Rigolet, Anne Surget, Inge Geurden, Lenaïg Richard, Nutrition, Métabolisme, Aquaculture (NUMEA), Institut National de la Recherche Agronomique (INRA), Aqualma, UNIMA, and The authors acknowledge Frederic Terrier and Peyo Aguirre for their help during diet manufacturing and to Marie Jo Borthaire and Vincent Michel for assistance with the laboratory analyses. Special thanks are due to Christian Ramamonjisoa (Aqualma facility) for his technical assistance. L. R., S. K. and I. G designed the study. L. R. did the data analysis. L. R., S. K. and I. G contributed to the drafting of the paper. A. S. did the AA analyses. L. R. and V. R. contributed to the organisation of the experiment in Madagascar. There are no contractual agreements for the presented data which might cause conflicts of interest. The authors acknowledge UNIMA and institutional funds from INRA for funding this study and ANRT (France) for the scholarship to L.R. (CIFRE PhD Research Grant).

Subjects
Aquatic Science, Penaeus monodon, 03 medical and health sciences, Nutrient, Fish meal, Animal science, plant protein, farine de poisson, Dry matter, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Meal, biology, fishmeal, fungi, 04 agricultural and veterinary sciences, biology.organism_classification, Shrimp, Biochemistry, Plant protein, digestibility, fisheries, [SDV.SA.STP]Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of fishery, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Corn gluten meal, shrimp, marine and freshwater biology, amino acid, penaeus monodon
Abstract

International audience; Two trials with juvenile black tiger shrimp (Penaeus monodon) were undertaken to study the effects of replacing fishmeal by different levels of plant proteins on growth performances and nutrient utilisation of shrimp in semi-intensive conditions (Expt. 1) and on the availability of dietary nitrogen (N) and amino acids (Expt. 2). Five isoproteic diets (on crude protein basis) were formulated to contain 34, 24, 16, 8, or 0% fishmeal, with fishmeal being replaced by a mixture of plant protein (corn gluten meal, wheat gluten, and rapeseed meal). In Expt. 1, the shrimp (initial body weight, IBW 1.5 ± 0.1 g) were reared in earthen ponds for 144 days and fed one of the experimental diets. Apparent digestibility of nutrients and AA were assessed in Expt. 2, using 150 L tanks and shrimp of 12.8 ± 0.4 g IBW. After 144 days in grow-out ponds, shrimp fed the diet with 24% of fishmeal had similar growth as those fed the control diet containing 34% fishmeal (0% replacement). When 50% or more of the fishmeal were replaced, weight gain as well as N and energy gains significantly decreased. Digestibility of dry matter, protein and energy was also significantly lower in all fishmeal-replaced diets. In particular, leucine digestibility decreased by 26% at 100% replacement, which was significantly correlated to an increased incorporation of corn gluten meal. Our data confirm the need to improve our knowledge on AA availability and raw material quality in order to improve fishmeal replacement in P. monodon diets.

Published
2011

16. Influence of the slicing technique on mechanical properties of the produced veneer

Author

Beate Buchelt, Alexander Pfriem, Institute of Wood and Paper Technology, and Technische Universität Dresden = Dresden University of Technology (TU Dresden)

Subjects
040101 forestry, 0106 biological sciences, Materials science, biology, Tension (physics), medicine.medical_treatment, Forestry, Young's modulus, 04 agricultural and veterinary sciences, Edge (geometry), biology.organism_classification, 01 natural sciences, Slicing, symbols.namesake, 010608 biotechnology, Physical Sciences, Perpendicular, symbols, medicine, 0401 agriculture, forestry, and fisheries, Engineered wood, General Materials Science, Veneer, Composite material, Beech
Abstract

International audience; The aim of this investigation was to compare the mechanical behaviour of lengthwise and plain sliced veneer of the species beech ( L.). Therefore, tension tests parallel and perpendicular to the grain were carried out. The results were evaluated using the variance analysis (ANOVA). As a result it can be stated that lengthwise sliced veneers exhibit significantly higher strength and better mechanical characteristics than plain sliced veneers. The checks parallel to the grain which occurred by manufacturing at that side of the veneer leaf which faces the cutting edge and which is stressed in tension are to be considered as reason therefore. In contrast to the tests parallel to the grain the modulus of elasticity perpendicular to the grain shows significantly lower values for lengthwise sliced veneers than for plain sliced veneers. Due to their higher strength values lengthwise sliced veneers are considered better base materials for engineered wood products than plain sliced veneers.

Published
2010

17. Influence of the adhesive layer on the mechanical properties of thin veneer-based composite materials

Author

André Wagenführ, Beate Buchelt, Institute of Wood and Paper Technology, and Technische Universität Dresden = Dresden University of Technology (TU Dresden)

Subjects
Materials science, medicine.medical_treatment, Young's modulus, 02 engineering and technology, chemistry.chemical_compound, symbols.namesake, Ultimate tensile strength, medicine, General Materials Science, Cellulose, Composite material, Wood fibre, Beech, 040101 forestry, biology, Forestry, 04 agricultural and veterinary sciences, 021001 nanoscience & nanotechnology, biology.organism_classification, chemistry, Physical Sciences, symbols, 0401 agriculture, forestry, and fisheries, Veneer, Adhesive, 0210 nano-technology, Layer (electronics)
Abstract

International audience; For the production of spliced veneers the veneers are coated with thin cellulose fleece or special paper layers, and thereby thin composites are generated. This article describes the mechanical properties of such a composite material consisting of 0.35 mm beech ( L.) veneer and a 0.12 mm cellulose fleece bonded with a PVAc adhesive.

Published
2009

18. BMC Genomics

Author

Grace C. Davey, Penelope K. Lindeque, Richard Reinhardt, Christophe Klopp, Pascal Favrel, Dario Moraga, Pierre Boudry, Sylvie Lapegue, Patrick Prunet, Arnaud Huvet, Julien de Lorgeril, Jeanne Moal, Viviane Boulo, Elodie Fleury, Christophe Lelong, Christopher Sauvage, Patrick Wincker, François Moreews, Michel Mathieu, Frédérick Gavory, Arnaud Tanguy, Caroline Fabioux, Charlotte Corporeau, Evelyne Bachère, Jenny P. Shaw, Yannick Gueguen, Laboratoire Environnement Ressources Morbihan Pays de Loire (LERMPL), LITTORAL (LITTORAL), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Physiologie et Ecophysiologie des Mollusques Marins (PE2M), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Ecosystèmes lagunaires : organisation biologique et fonctionnement (ECOLAG), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), Adaptation et diversité en milieu marin (ADMM), Institut national des sciences de l'Univers (INSU - CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Brest (UBO), Plymouth Marine Laboratory (PML), Max-Planck-Institut für Molekulare Genetik (MPIMG), Max-Planck-Gesellschaft, Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE), Institut National de la Recherche Agronomique (INRA), Génétique fonctionnelle, agronomie et santé [IFR 140] (GFAS), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Diagnostics Centre (NDC), National University of Ireland [Galway] (NUI Galway), Laboratoire de Génétique et Pathologie (LGP), Amélioration génétique, du contrôle des performances et de la santé des mollusques marins (AGSAE), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Biological systems and models, bioinformatics and sequences (SYMBIOSE), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria), Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Système d'Information des GENomes des Animaux d'Elevage (SIGENAE), Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) (UBIA), Laboratoire de Physiologie des Invertébrés (LPI), Physiologie Fonctionnelle des Organismes Marins (PFOM), The research presented in this paper was performed within the framework of several research projects funded by: Genoscope (11/AP2006-2007), Marine Genomics Network of Excellence (GOCE-CT-2004-505403), the European project 'Aquafirst' (513692) in the Sixth Framework Program, ANR 'CgPhysiogène' (ANR-06-GANI-0009) and 'Gametogenes' (ANR-08-GENM-041), ANR-06-GANI-0009,CgPhysiogene,Bases moléculaires des fonctions physiologiques de l'huître Crassostrea gigas : interactions hôte/pathogène/milieu(2006), ANR-08-GENM-0041,Gametogenes,Génomiques de la gamétogénèse chez l'huître creuse Crassostrea gigas(2008), Laboratoire Laboratoire Environnement Ressources Morbihan Pays de Loire (LER/MPL), Institut de Recherche pour le Développement (IRD)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), Adaptation et Biologie des Invertébrés en Conditions Extrêmes (ABICE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Plymouth Marine Laboratory, Institut National de la Recherche Agronomique (INRA)-IFR140, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Rennes – Bretagne Atlantique, Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), Unité de Biométrie et Intelligence Artificielle de Toulouse [Castanet-Tolosan] (UBIA), Institut National de la Recherche Agronomique (INRA)-Plateforme bioinformatique du GIS GENOTOUL - Génopole Toulouse Midi-Pyrénées, Laboratoire de Physiologie des Invertébrés [Plouzané] (LPI), Adaptation et diversité en milieu marin (AD2M), Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Recherche Agronomique (INRA), Station biologique de Roscoff (SBR), and Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Oyster, genome annotation, génomique fonctionnelle, computer.software_genre, Genome, User-Computer Interface, single nucleotide polymorphisms, Databases, Genetic, crassostrea gigas, structure du génome, Expressed Sequence Tags, base de données, 0303 health sciences, Expressed sequence tag, biology, Database, 04 agricultural and veterinary sciences, Genomics, crustacea, Pacific oyster, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], energy-balance, factor-beta superfamily, DNA microarray, expression des gènes, Biotechnology, lcsh:QH426-470, Sequence analysis, lcsh:Biotechnology, kappa-b, Polymorphism, Single Nucleotide, génomique, 03 medical and health sciences, biology.animal, lcsh:TP248.13-248.65, Genetics, summer mortality, Animals, Crassostrea, 030304 developmental biology, Gene Library, Whole genome sequencing, [SDV.GEN]Life Sciences [q-bio]/Genetics, huître, cell-development, génome, Gene Expression Profiling, linkage maps, Sequence Analysis, DNA, biology.organism_classification, lcsh:Genetics, coquillage, 040102 fisheries, 0401 agriculture, forestry, and fisheries, identification, marine genomics, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], computer, Microsatellite Repeats
Abstract

Background Although bivalves are among the most-studied marine organisms because of their ecological role and economic importance, very little information is available on the genome sequences of oyster species. This report documents three large-scale cDNA sequencing projects for the Pacific oyster Crassostrea gigas initiated to provide a large number of expressed sequence tags that were subsequently compiled in a publicly accessible database. This resource allowed for the identification of a large number of transcripts and provides valuable information for ongoing investigations of tissue-specific and stimulus-dependant gene expression patterns. These data are crucial for constructing comprehensive DNA microarrays, identifying single nucleotide polymorphisms and microsatellites in coding regions, and for identifying genes when the entire genome sequence of C. gigas becomes available. Description In the present paper, we report the production of 40,845 high-quality ESTs that identify 29,745 unique transcribed sequences consisting of 7,940 contigs and 21,805 singletons. All of these new sequences, together with existing public sequence data, have been compiled into a publicly-available Website http://public-contigbrowser.sigenae.org:9090/Crassostrea_gigas/index.html. Approximately 43% of the unique ESTs had significant matches against the SwissProt database and 27% were annotated using Gene Ontology terms. In addition, we identified a total of 208 in silico microsatellites from the ESTs, with 173 having sufficient flanking sequence for primer design. We also identified a total of 7,530 putative in silico, single-nucleotide polymorphisms using existing and newly-generated EST resources for the Pacific oyster. Conclusion A publicly-available database has been populated with 29,745 unique sequences for the Pacific oyster Crassostrea gigas. The database provides many tools to search cleaned and assembled ESTs. The user may input and submit several filters, such as protein or nucleotide hits, to select and download relevant elements. This database constitutes one of the most developed genomic resources accessible among Lophotrochozoans, an orphan clade of bilateral animals. These data will accelerate the development of both genomics and genetics in a commercially-important species with the highest annual, commercial production of any aquatic organism.

Published
2009