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2 results on '"de Pereira MU"'

1. How well do questionnaires perform compared with physical examination in detecting flexural eczema? Findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two

Author

Flohr, C., Weinmayr, G., Weiland, S. K., Addo-Yobo, E., Annesi-Maesano, Isabella, Björkstén, B., Bråbäck, L., Büchele, G., Chico, M., Cooper, P., Clausen, M., El Sharif, N., Martinez Gimeno, A., Mathur, R. S., von Mutius, E., Morales Suarez-Varela, M., Pearce, N., Svabe, V., Wong, G. W. K., Yu, M., Zhong, N. S., Williams, H. C., Renseigné, Non, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Geology, Ball State University, School of Biosciences [Cardiff], Cardiff University, Flohr C, G Weinmayr, M Clausen, El Sharif N, Martinez Gimeno A, RS Mathur, Mutius von E, Morales-Suarez Varela M, N Pearce, V Svabe, Wong GW, M Yu, SK Weiland, Zhong NS, Williams HC, Phase Deux Groupe d'étude ISAAC .G Büchele, Genuneit J, Kleiner A, G Nagel, Weinmayr G, Priftanji A, A Shkurti, Simenati J, E-Addo Yobo, E Grabocka, K Shyti, S Agolli, Gurakuqi A, RT Stein, de Pereira MU, MH Jones, PM Pitrez, Cooper PJ, YZ Chen, Annesi-Maesano I, C Lai, Wong G, MA Riikjärv, T Annus, M Gotua, M Rukhadze, T Abramidze, Kvachadze I, L Karsanidze, M Kiladze, B Bjorksten, N Dolidze, Leupold W, U Keil, von Mutius E, Arthur P, C Gratziou, C Priftis, Papadopoulou A, C Katsardis, Tsanakas J, L Bråbäck, E Hatziagorou, Kirvassilis F, JR Shah, RP Khubchandani, S Mantri, Forastière F, G Büchele, M Chico, and P Cooper

Subjects
Male, Allergy, medicine.medical_specialty, Eczema, Physical examination, Dermatology, Severity of Illness Index, Atopy, 030207 dermatology & venereal diseases, 03 medical and health sciences, MESH: Physical Examination, 0302 clinical medicine, Risk Factors, immune system diseases, MESH: Risk Factors, Germany, Surveys and Questionnaires, MESH: Child, MESH: Severity of Illness Index, Epidemiology, Prevalence, otorhinolaryngologic diseases, medicine, Humans, 030212 general & internal medicine, Child, skin and connective tissue diseases, Physical Examination, MESH: Germany, MESH: Prevalence, Asthma, Symptom prevalence, MESH: Humans, medicine.diagnostic_test, business.industry, MESH: Questionnaires, Atopic dermatitis, medicine.disease, MESH: Male, 3. Good health, Surgery, El Niño, MESH: Eczema, Family medicine, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract

International audience; BACKGROUND: Questionnaires are widely used in epidemiological studies to measure eczema symptom prevalence, but there are concerns regarding their accuracy if used as a diagnostic tool. OBJECTIVES: To compare the performance of a validated eczema symptom questionnaire and a standardized skin examination protocol employed in the second phase of the International Study of Asthma and Allergies in Childhood (ISAAC). METHODS: A total of 30,358 schoolchildren aged 8-12 years from 18 countries were examined for flexural eczema. Parents also completed an eczema symptom questionnaire. We compared prevalence estimates at the population level based on the questionnaire vs. physical examination. We also compared the skin examination and the ISAAC questionnaire in making a diagnosis of flexural eczema. RESULTS: The point prevalences for flexural eczema at centre level based on a single examination were lower than the questionnaire-based 12-month period prevalences (mean centre prevalence 3.9% vs. 9.4%). Correlation between prevalences of both outcome measures was high (r = 0.77, P < 0.001). At the individual level, questionnaire-derived symptoms of 'persistent flexural eczema in the past 12 months' missed < 10% of cases of flexural eczema detected on physical examination. However, between 33% and 100% of questionnaire-based symptoms of 'persistent flexural eczema in the past 12 months' were not confirmed on examination. CONCLUSIONS: ISAAC questionnaire-derived symptom prevalences are sufficiently precise for comparisons between populations. Where diagnostic precision at the individual level is important, questionnaires should be validated and potentially modified in those populations beforehand, or a standardized skin examination protocol should be used.

Published
2009

2. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II

Author

Weinmayr, G., Forastiere, F., Weiland, S. K., Rzehak, P., Abramidze, T., Annesi-Maesano, Isabella, Björkstén, B., Brunekreef, B., Büchele, G., Cookson, W. O. C., Von Mutius, E., Pistelli, R., Strachan, D. P., Renseigné, Non, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), G Büchele, Garcia-Hernandez G, SK Weiland, Groupe d'étude ISAAC Phase II . Collaborateurs (149) Bjorksten B, B Brunekreef, W Cookson, Strachan D, E von Mutius, Kleiner A, G Nagel, P Rzehak, G Weinmayr, Priftanji A, A Shkurti, Simenati J, Grabocka E, Shyti K, S Agolli, Gurakuqi A, RT Stein, de Pereira MU, MH Jones, B Bjorksten, PM Pitrez, Cooper PJ, M Chico, Zhong NS, C Lei, Wong G, MA Riikjärv, T Annus, Annesi-Maesano I, M Gotua, YZ Chen, M Rukhadze, T Abramidze, Kvachadze I, L Karsanidze, M Kiladze, N Dolidze, W Leupold, U Keil, von Mutius E, Arthur P, Wang H, E-Addo Yobo, C Gratziou, C Priftis, Papadopoulou A, C Katsardis, Tsanakas J, E Hatziagorou, Kirvassilis F, M Clausen, JR Shah, W Nystad, RS Mathur, RP Khubchandani, S Mantri, Forastière F, Di Domenicantonio R, De Sario M, S Sammarro, R Pis, Y Saraclar, L Bråbäck, Batlles-Garrido J, and Çocuk Sağlığı ve Hastalıkları

Subjects
Male, Pediatrics, Time Factors, MESH: Asthma, MESH: Respiratory Sounds, Respiratory System, Breastfeeding, MESH: Logistic Models, MESH: Respiratory Function Tests, Atopy, MESH: Conjunctivitis, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, MESH: Child, 030212 general & internal medicine, Child, MESH: Rhinitis, Respiratory Function Tests, 3. Good health, Breast Feeding, MESH: Breast Feeding, Female, Bronchial Hyperreactivity, medicine.symptom, Pulmonary and Respiratory Medicine, medicine.medical_specialty, MESH: Socioeconomic Factors, MESH: Allergens, MESH: Hypersensitivity, 03 medical and health sciences, MESH: Cross-Sectional Studies, MESH: Skin Tests, Wheeze, medicine, Humans, MESH: Prevalence, Respiratory Sounds, Retrospective Studies, Asthma, MESH: Humans, MESH: Rhinitis, Allergic, Perennial, business.industry, MESH: Questionnaires, MESH: Time Factors, MESH: Bronchial Hyperreactivity, MESH: Rhinitis, Allergic, Seasonal, MESH: Retrospective Studies, Odds ratio, medicine.disease, Confidence interval, MESH: Male, Logistic Models, Socioeconomic Factors, 030228 respiratory system, El Niño, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Breast feeding, MESH: Seasons, MESH: Female, MESH: Models, Statistical
Abstract

International audience; The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).

Published
2009

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