1. Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study
- Author
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Castagliola, D, Ledergerber, B, Torti, Carlo, van Sighem, A, Podzamczer, D, Mocroft, A, Dorrucci, M, Masquelier, B, de Luca, A, Jansen, K, De Wit, S, Obel, N, Fätkenheuer, G, Touloumi, G, Mussini, C, Castagna, A, Stephan, C, Garcia, F, Zangerle, R, Duval, X, Pérez Hoyos, S, Meyer, L, Ghosn, J, Fabre Colin, C, Kjaer, J, Chene, G, Grarup, J, Costagliola, D, Lodwick, R, Phillips, A, Pursuing Later Treatment Option II project team, Observational HIV Epidemiological Research Europe Group, Costagliola, D, Lodwick, R, Ledergerber, B, Collaboration Of Observational Hiv Epidemiological Research Europe (COHERE) Grp, Castagna, Antonella, Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, and Infectious diseases
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Anti-HIV Agents ,HIV-1 ,CD4 Lymphocyte Count ,Cohort Studies ,Female ,HIV Infections ,Humans ,Middle Aged ,RNA ,Viral ,Regression Analysis ,Retrospective Studies ,Young Adult ,Settore MED/17 - MALATTIE INFETTIVE ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,RNA, Viral -- blood ,Internal medicine ,medicine ,HIV ,AIDS ,viral load ,Protease inhibitor (pharmacology) ,030212 general & internal medicine ,Poisson regression ,Young adult ,Pathologie maladies infectieuses ,HIV Infections -- blood -- drug therapy -- virology ,0303 health sciences ,030306 microbiology ,business.industry ,Incidence (epidemiology) ,Retrospective cohort study ,Sciences bio-médicales et agricoles ,medicine.disease ,3. Good health ,Infectious Diseases ,Immunology ,symbols ,RNA, Viral ,Anti-HIV Agents -- therapeutic use ,business ,Viral load ,Cohort study - Abstract
Limited treatment options have been available for people with HIV who have had virological failure of the three original classes of HIV antiretroviral drugs-so-called triple-class virological failure (TCVF). However, introduction of new drugs and drug classes might have improved outcomes. We aimed to assess trends in virological and clinical outcomes for individuals with TCVF in 2000-09., info:eu-repo/semantics/published
- Published
- 2012