1. A virtual look at Epstein–Barr virus infection: Simulation mechanism
- Author
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Shapiro, M., Duca, K.A., Lee, K., Delgado-Eckert, E., Hawkins, J., Jarrah, A.S., Laubenbacher, R., Polys, N.F., Hadinoto, V., and Thorley-Lawson, D.A.
- Subjects
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EPSTEIN-Barr virus , *COMPUTER simulation , *T cells , *BLOOD , *LYMPH , *INFECTION - Abstract
Abstract: Epstein–Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer''s ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death. [Copyright &y& Elsevier]
- Published
- 2008
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