1. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
- Author
-
Lin SJ and Guarente L
- Subjects
- Aging metabolism, Animals, Humans, Metabolic Diseases genetics, Metabolic Diseases metabolism, Metabolic Diseases physiopathology, Sirtuins genetics, Sirtuins metabolism, Aging genetics, Eukaryotic Cells metabolism, Genes, Regulator physiology, Longevity genetics, NAD metabolism
- Abstract
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
- Published
- 2003
- Full Text
- View/download PDF