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Objectives: Aging is associated with declines in theory of mind - the ability to infer the mental states of others. We examined whether priming theory of mind mindsets actively (Study 1) and passively (Study 2) improved older adults' performance., Method: Across two studies, participants completed a novel question-and-answer theory of mind task using the television show Nathan for You ® in a mindset or no mindset condition. In Study 1, participants ( N  = 324, 18-84 years) completed a similar task related to a different show prior to the Nathan for You task (active mindset). In Study 2, young ( N  = 235; M Age = 20.47) and older ( N  = 193, M Age = 74.48) adults made continuous ratings of awkwardness of different episodes of Nathan for You before completing the question-and-answer task (passive mindset). We also measured executive function and episodic memory. In both studies, the same tasks were performed in reverse order for the control conditions (no mindset)., Results: Mindsets were associated with small-to-medium increases in theory of mind performance. Cognitive ability did not explain these improvements., Conclusion: These findings suggest that theory of mind performance can be improved through motivation (e.g. mindsets); cognitive function (e.g. ability) does not moderate this relationship.

Introduction: To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted., Methods: All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023., Results: Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7., Conclusion: The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers., Competing Interests: Declaration of competing interest The authors of this article declare that they have no competing interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)

Age-related hand motor impairments may critically depend on visual information though few studies have examined eye movements during tasks of hand function in older adults. The purpose of this study was to assess eye movements and their association with performance while tracing on a touchscreen in young and older adults. Eye movements of 21 young (age 20-38 years; 12 females, 9 males) and 20 older (65-85 years; 10 females, 10 males) adults were recorded while performing an Archimedes spiral tracing task, a common clinical assessment sensitive to age-associated impairments in hand function. Participants traced an Archimedes spiral template on a touchscreen as accurately as possible under three conditions, using (1) a stylus, (2) the index finger, and (3) the index finger while performing a visuospatial dual task. Older adults made fewer total fixations than young adults, and participants made fewer fixations when tracing parts of the spiral where vision of the spiral template was likely more obstructed by the hand. Inter-fixation distance and inter-fixation distance variability were greater in older compared to young adults. A relationship between increased inter-fixation distance and increased spiral tracing error demonstrates the association between age-related changes in eye movements and spiral tracing performance in older adults. Results contribute novel findings of age-associated changes in ocuomotor behavior during a common clinical assessment and offer insight into motor control in older adults., Competing Interests: Declarations. Conflict of interest: The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. All protocols were approved by the Institutional Review Board of the University of Wisconsin-Milwaukee. Consent to participate: Written informed consent was obtained from all participants included in this study. Consent for publication: Participants signed informed consent regarding publishing their data., (© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Background: To investigate the associations between five depressive symptom trajectories and cognitive impairment in Taiwan's older population. In addition, we investigated the moderating factors influencing these associations., Methods: This population-based, longitudinal, cohort study was conducted on the basis of the Taiwan Longitudinal Study on Aging. Data corresponding to the fifth (2003), sixth (2007), and seventh (2011) survey waves were analyzed, focusing on individuals aged ≥ 65 years. Depressive symptom trajectories were analyzed using the 10-item Centre for Epidemiological Studies Depression scale, and cognitive function was assessed using the Short Portable Mental State Questionnaire. Logistic regression models were adjusted for various covariates such as sociodemographic, lifestyle, and health-related variables. We also investigated moderating effects of sex, age, type 2 diabetes mellitus, hypertension, and coronary heart disease., Results: Five trajectories of depressive symptoms included 1,549 older individuals were identified. Approximately 36.09%, 47.13%, 5.68%, 6.20%, and 4.91% exhibited no, mild, decreasing, increasing, and persistent depressive symptom trajectories, respectively. The odds ratios for cognitive impairment were 3.17 (95% confidence interval [CI]: 1.41-7.15) in Model 1; 3.24 (95% CI: 1.42-7.41) in Model 2; and 2.95 (95% CI: 1.24-7.00) in Model 3 in individuals with persistent depressive symptom trajectory. Only persistent depressive symptom trajectory reached statistical significance in all three models. Cognitive decline was evident across all trajectories. The rate of cognitive decline was more rapidly in the persistent depressive symptom trajectory, nearly twofold to no depressive symptom trajectory, which the corresponding β values (score/year) were - 0.0862, - 0.1020, - 0.1192, - 0.1206, and - 0.1683 for the no, mild, decreasing, increasing, and persistent depressive symptom trajectories, respectively. Female sex, older age, type 2 diabetes mellitus, and coronary heart disease were significant moderators on the risk of cognitive impairment., Discussion: Persistent depressive symptoms is associated with cognitive impairment in older adults. Identifying high-risk subgroups is crucial for targeted assistance. Policymakers and health-care professionals should be informed accordingly., Competing Interests: Declarations. Ethics approval and consent to participate: The TLSA was approved by the Research Ethics Committee of the Bureau of Health Promotion, Department of Health, Taiwan (10000800524). All participants signed an informed consent form before the interviews. The illiterate participants signed the consent form after confirmation by their accompanying families. All methods were carried out in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

Objective: Explore motor imagery (MI) abilities in healthy older adults compared with healthy younger adults., Methods: A systematic review with meta-analysis., Results: Twenty-seven cross-sectional studies were included. Meta-analyses explored MI abilities between healthy older and younger adults for the ability to generate kinesthetic (60-70 years: g  = -0.24, 95%CI = -1.61, 1.13; 70-80 years: g  = -1.29, 95%CI = -2.75, 0.17), and visual modality ( g  = -0.08, 95%CI = -0.71, 0.86); vividness in kinesthetic ( g  = 0.14, 95%CI = -0.13, 0.41), IV ( g  = 0.11, 95%CI = -0.16, 0.38), and EV modalities ( g  = 0.05, 95%CI = -0.15, 0.24); mental chronometry in timed-up and go (seconds = 0.63, 95%CI = -0.02, 1.27), and linear walk (seconds = 0.75, 95%CI = -0.55, 2.06); and MI-execution time congruence (performance overestimation) in linear walk ( g  = -0.02, 95%CI = -0.73, 0.69). Mental chronometry in upper limb movements was analyzed visually in forest plot indicating tendencies of greater time in older adults. Hand recognition in hand laterality judgment task visual analysis revealed a poorer accuracy, greater response time and lower efficiency in older adults., Conclusion: Vividness of MI in kinesthetic and visual modalities appears to be preserved in older adults. Tendencies for greater time in mental chronometry were observed in older adults in TUG, linear walk and upper limb tasks. Implicit MI assessed with hand laterality showed older adults have lower accuracy, longer response times and lower efficiency. The ability to generate MI in kinesthetic and visual modalities presented imprecise results, and no clear conclusions could be drawn on MI-execution temporal congruence due to imprecision. Further research is needed to potentially clarify these findings., Systematic Review Registration: PROSPERO: CRD42023384916., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025 Fierro-Marrero, González-Iglesias, Melis-Romeu, López-Vidal, Paris-Alemany and La Touche.)

Objectives: This research seeks to explore the relationship between Internet use and attitudes toward aging among older adults in China, with a particular emphasis on the mediating role of health in this correlation., Methods: A national survey of 10,858 Chinese adults aged 60 and above was conducted, employing multiple linear regression and structural equation modeling to analyze the impact of Internet use on aging attitudes with health as a mediator., Results: The research found a significant positive association between Internet use and positive aging attitudes ( β  = -1.420, p  < 0.001). Health indicators-self-rated, physical, and mental health-were identified as key moderators, with healthier adults benefiting more from Internet use., Conclusion: This research reveals a positive association between Internet use and attitudes toward aging among older adults in China. These findings hold substantial implications for encouraging active and healthy aging in the digital era, underscoring the value of advocating for digital engagement among seniors as a means to improve their quality of life., Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025 Wang.)

Forward propulsion depends on the forces generated by the triceps surae muscles and transmitted through the muscles' subtendons, which merge and twist to form the Achilles tendon (AT). As people age, the AT may undergo structural changes that could alter the subtendons' ability to transmit forces or function with some independence; prominent changes include increased tendon compliance and a proliferation of interfascicular adhesions compared to younger tendon. However, the effects of age-related changes on the subtendons are difficult to isolate in vivo. Here, we used a Hill-type musculoskeletal model of the triceps surae muscle-subtendon units to simulate the effects of age-related changes on gastrocnemius (GAS) and soleus (SOL) muscle contractile dynamics across a range of physiological force levels during fixed-end contractions. We simulated individual and dual muscle excitations with altered tendon compliance (ε o  = 3 %, 6 %, 9 %) and inclusion of a shared tendon. Consistent with fundamental muscle mechanics, compared to stiffer tendons, increased tendon compliance elicited more than three times the GAS and SOL fiber shortening and greater muscle excitation - effects that increased with requisite force demand. However, our model results also suggest combinatory effects of increased tendon compliance and interfascicle adhesions in the aging AT that deleteriously amplify redistribution from the GAS to the SOL which may be functionally detrimental during gait., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Existing literature explores the relationship between voluntary work, loneliness, and social isolation, but there is a lack of research on how the onset and cessation of voluntary work relate to loneliness and social isolation among older adults. Many in this population may discontinue volunteering due to various life circumstances, making it important to investigate the longitudinal significance of these transitions. This study aims to assess whether engaging in volunteer work during retirement age is associated with changes in loneliness and social isolation., Methods: Longitudinal data were obtained from Waves 5 (Year 2014) and 6 (Year 2017) of the German Ageing Survey, focusing on middle-aged and older adults. The sample size (n = 6628) was limited to those aged 65 and above. Two groups were analyzed: the onset group, individuals who did not volunteer in 2014 but did by 2017 (188 individuals), and the cessation group, those who volunteered in 2014 but not by 2017 (307 individuals). Loneliness was assessed using the De Jong Gierveld tool, and perceived social isolation was measured using the Bude and Lantermann instrument. Asymmetric linear fixed effects (FE) regression analysis examined the associations., Results: In an asymmetric FE regression analysis that adjusted for a multitude of time-varying covariates, an association was shown between the onset of volunteer work and decreases in loneliness (β = -0.07; p = 0.04) in older adults. In contrast, there was no significant association between the onset of voluntary work and changes in perceived social isolation. Also, there was no significant association between the cessation of volunteer work and changes in perceived social isolation or loneliness., Conclusion: Our findings suggest that older adults who choose to volunteer may experience a decrease in self-reported loneliness. Further longitudinal studies are needed to confirm our present findings., (© 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)

Background: Plant-based diets are associated with various health benefits; however, their impact on physical performance in aging populations remains unclear., Objectives: To investigate the associations between adherence to plant-based diets and physical performance, focusing on their potential protective effects against age-related declines in function., Methods: Data were obtained from men and women aged 40 years or older in the Baltimore Longitudinal Study of Aging (BLSA) (mean ± SD age: 68 ± 13 years at the first dietary visit; n = 1389). Dietary intake was assessed using a food frequency questionnaire (FFQ). Plant-based diets, calculated from 18 food groups, were categorized as overall (PDI), healthful (hPDI), or unhealthful (uPDI), and their tertiles across visits were analyzed. Multivariable linear mixed-effects models were used to examine the association between repeated measurements of three physical performance outcomes-Short Physical Performance Battery (SPPB), grip strength (kg), and gait speed (m/s)-and adherence to each plant-based diet., Results: In fully adjusted models, SPPB and grip strength were significantly associated with both hPDI and uPDI, but not with PDI. For hPDI, the intermediate tertile showed the greatest benefit, with SPPB scores 0.5 points higher (β T2vs.T1 = 0.50, 95% CI: 0.30-0.70, p < 0.001) over the follow-up period. In contrast, for uPDI, a 0.27-point lower SPPB score was seen (β T3vs.T1 = -0.27, 95% CI: -0.48 to -0.07, p = 0.009). Longitudinally, grip strength was positively associated with hPDI (β T3vs.T1 = 1.14, 95% CI: 0.24-2.05, p = 0.0013). Similar results were observed in older adults aged ≥65 years., Conclusions: Adherence to hPDI may benefit lower body function and muscle strength, while uPDI appears to have adverse effects. This suggests that the quality of plant-based foods is essential for maintaining functional well-being in older adults. Further research is needed to confirm these findings, explore underlying mechanisms, and identify strategies to optimize plant-based dietary patterns for aging populations.

Background: It is critical to age successfully for general health considering the aging of the global population. Successful aging is an important indicator to assess whether older individuals are experiencing a healthy life and high-quality aging. This study aimed to explore the longitudinal relationship between the frequency and number of participation in leisure activities and the maintenance of successful aging., Methods: This longitudinal study included a total of 1,828 Chinese adults aged 60 years or older. The following six activities were gathered to reflect leisure activities: reading books or newspapers, gardening work, playing mahjong or cards, listening to radio or watching TV, raising pets or domestic animals, and engaging in social activities. We evaluated successful aging using a multidimensional model which includes the following five components: better self-reported health, good psychological status, high cognitive function, free of disability, and better physical activity level., Results: This study showed a retention rate of 58.4% for successful aging during a 4-year follow-up. Participants who frequently engaged in reading books or newspapers, gardening work, playing mahjong or cards, and listening to radio or watching TV, had higher rates of future successful aging maintenance (OR: 1.50, 95% CI: 1.04-2.22 to 1.89, 95% CI: 1.26-2.812) than those who never participated in these activities. Compared to those with 0 leisure activity, participants with 3 (OR: 1.78, 95% CI: 1.14-2.77) and 4-6 (OR: 1.65, 95% CI: 1.01-2.71) leisure activities had a greater probability of maintaining successful aging., Conclusions: These findings suggest that individuals who participated more frequently in more leisure activities had a higher chance of the maintenance of successful aging in older adults. Encouraging older people to frequently participate in a greater variety of leisure activities may be an effective way to maintain successful aging over time., Competing Interests: Declarations. Ethics approval and consent to participate: Every participant signed a written informed consent form prior to the survey. This study project was carried out in accordance with the Declaration of Helsinki and was evaluated and approved by the Peking University Research Ethics Committee (registration number: IRB00001052-13074). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Objective: This population-based study aimed to evaluate the association of mental health and several sleep conditions with Social Frailty (SF) in a sample of Iranian middle-aged and older adults., Method: This cross-sectional study was conducted using data from the Ardakan Cohort Study on Aging (ACSA). SF was assessed by five questions: inability to help others, limited social participation, loneliness, financial difficulty, and not having anyone to talk to (HALFT). Based on the responses, the participants were divided into three groups: social robust (a score of 0), pre-SF (a score of 1-2), and SF (a score of ≥3). Mental health factors included depression and anxiety. Within the domain of sleep conditions, considerations included sleep duration, quality, subjective sleep health, and daytime sleepiness. The logistic regression models were employed to analyze the data., Results: A total of 5782 subjects participated in the study, with females comprising 50.7% of the sample. This study revealed the total prevalence of pre-SF and SF were 76.4 and 9.3%, respectively. After adjusting for age, sex, marital status, education, number of comorbidities, and mental health, in the age group of 50-60 years, anxiety (borderline and abnormal compared to normal, OR = 1.49, 95% CI: 1.05-2.11 and OR = 1.98, 95% CI: 1.26-3.12, respectively) were associated with SF. Similarly, in the age group of 60 years and above, only depression was associated with SF (OR = 2.24, 95% CI: 1.45-3.44)., Conclusion: These findings imply that mental health might contribute to SF in the middle-aged and older Iranian population.

Falls are a significant health risk in older adults, and forward and backward falls each account for more than 40 % of falls. Dynamic stability, limb support, and impact energy absorption are crucial balance regulatory components and likely vary with the direction of imbalance. Understanding how perturbation direction influences these key components of balance stability regulation is crucial. This study investigated the balance stability, lower limb impact energy absorption, and limb support in forward and backward directions of balance perturbations in younger versus older adults. Thirteen healthy old and thirteen healthy young adults participated in this study. Participants stood on two adjacent perturbation platforms in modified tandem stance. The leading or trailing limb support surface dropped 76.2 mm vertically at an unknown time to impose body shift. Two-way (direction X group) mixed ANOVA was performed to analyze the anterior margin of stability (MoS), trunk angular displacement, peak negative power at the hip, knee, and ankle, and the peak vertical ground reaction forces (VGRF). Compared to forward perturbation, backward perturbation induced greater MoS (P < 0.01), peak VGRF (P < 0.01), and peak ankle (P < 0.05) and hip (P < 0.05) joint power. Older adults showed decreased MoS (P < 0.05), perturbed limb peak VGRF (P < 0.05), and ankle (P < 0.05) and knee (P < 0.05) joint peak power compared to younger adults. Forward perturbations induced greater challenges for dynamic stability, possibly due to trunk motion characteristics, while backward perturbations posed challenges in limb support and impact energy absorption. In addition, age-related deficits in balance stability regulation were observed in both perturbation directions., Competing Interests: Declaration of competing interest None., (Published by Elsevier B.V.)

This paper explores the intersection of climate change, population aging, and community resilience, focusing on the potentially powerful roles of older adults in climate change mitigation efforts, particularly in developing countries. Through a brief review of relevant literature in the fields of environmental studies, gerontology, and community development, the paper examines the vulnerabilities of older adults to climate change impacts and their potential contributions to adaptation and mitigation strategies. By integrating findings from some existing literature, the paper contributes to ongoing conversations about the inclusivity of climate change actions and the empowerment of marginalized groups. Our suggestions include harnessing the traditional knowledge and leadership of older adults and empowering them to act as climate change activists within their communities. Additionally, the paper suggests encouraging older adults to organize community capacity-building workshops that advocate for environmentally sustainable initiatives. We conclude by emphasizing that neglecting older adults in the climate change discourse risks exacerbating entrenched social inequalities and overlooks the potentially valuable resources and knowledge that older adults can contribute toward climate change mitigation and adaptation. This therefore calls for the recognition of older adults as vital agents of change and empowering them through inclusive development policies, programs, and initiatives. Future research should investigate the long-term impacts of inviting older adults into climate change mitigation efforts, and the barriers that may hinder their active engagement., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Purpose: The number of people living and ageing with HIV is increasing. Insight into their well-being is lacking. The present study was conducted to explore needs, psychosocial issues and experiences of ageing in older adults living with human immunodeficiency virus (HIV) in Sweden., Methods: A qualitative approach was employed. Semi-structured interviews were conducted with a convenience sample of 22 participants aged 65 years or older living with HIV in Sweden. Thematic analysis based on descriptive phenomenology was used., Results: Being an older adult living with HIV emerged as a multifaceted experience. The meaning and impact of HIV varied from minimal to substantial, and ageing could overshadow the significance of HIV in everyday life. Three themes emerged: 1) increasing age in the foreground, 2) internalizing HIV in everyday life, and 3) socioemotional impact on everyday life., Conclusions: The findings suggest a need for a more holistic approach to care of older adults living with HIV, recognizing the broader context of healthy ageing. While participants experienced good health, challenges related to ageing persist, and experiencing HIV-related stigma. The findings highlight the importance of empowering older adults living with HIV.

Objectives: Although anxiety and depression decrease across the lifespan, age-related anxieties increase in older adults, particularly worries about experiencing cognitive decline or dementia. Dementia Worry (DW) is characterized by ruminative concerns about developing or experiencing symptoms of dementia. DW is related to negative mental health outcomes in older adults and increases as a function of exposure to dementia in others. What is less clear is the way in which other risk factors, such as intolerance of uncertainty (IU), are associated with DW, and whether an individual's personal dementia exposure moderates this association., Method: The purpose of the present study was to investigate whether DW is related to anxiety and depression in older adults ( N  = 135), to investigate the relation between IU and DW, and to examine whether dementia exposure moderates this relation., Results: As expected, IU was related to anxiety and depression in older adults, similar to findings in younger adults. Further, as hypothesized, IU and DW were related in the sample; contrary to expectations, this association was found only in the group with non-genetic exposure to dementia., Conclusion: These findings may be useful for developing prevention efforts or interventions aimed at IU or DW in older adults, particularly those with personal dementia exposure.

Air pollution, particularly fine particulate matter (PM 2.5 ) with <2.5 μm in diameter, is a major public health concern. Studies have consistently linked PM 2.5 exposure to a heightened risk of cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), heart failure (HF), and cardiac arrhythmias. Notably, individuals with pre-existing age-related cardiometabolic conditions appear more susceptible. However, the specific impact of PM 2.5 on CVDs susceptibility in older adults remains unclear. Therefore, this review addresses this gap by discussing the factors that make the elderly more vulnerable to PM 2.5 -induced CVDs. Accordingly, we focused on physiological aging, increased susceptibility, cardiometabolic risk factors, CVDs, and biological mechanisms. This review concludes by examining potential interventions to reduce exposure and the adverse health effects of PM 2.5 in the elderly population. The latter includes dietary modifications, medications, and exploration of the potential benefits of supplements. By comprehensively analyzing these factors, this review aims to provide a deeper understanding of the detrimental effects of PM 2.5 on cardiovascular health in older adults. This knowledge can inform future research and guide strategies to protect vulnerable populations from the adverse effects of air pollution., Competing Interests: Declaration of competing interest All authors sincerely declare that there are neither financial nor personal relationships with other people or organizations that inappropriately influenced our work in submission. Furthermore, there is neither professional nor other personal interest of any kind, including services and/or companies that could be construed as influencing the position presented in our review article., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

This study corresponds with a dispute in gerontology literature about whether a younger subjective age acts as a psychological defense for older adults by perceiving themselves as younger in order to dissociate from their age-group or as a marker of good physical health. This cross-sectional study presents a preliminary step to clarify this dispute. We examined the role of emotional empathy (measured by the Multifaceted Empathy Test) as a moderator in the ageism (measured implicitly by the Brief Implicit Association Test) and subjective age (measured on Likert scale) association on a convenience sample of 203 community-dwelling older adults (aged 65-90, M = 74.54, SD = 6.76). It was hypothesized that implicit ageism would be associated with younger subjective age and that this association would be only evident among older adults with lower emotional empathy. Implicit ageism was not associated with younger subjective age. As expected, hierarchical linear regression showed that the connection between higher implicit ageism and a younger subjective age remains significant (p = 0.012) only among participants with lower emotional empathy (∆R 2  = 0.022, β = 0.156). Higher emotional empathy was associated with younger subjective age. For older adults who are equipped with the ability to feel others' emotions, the defensive dissociation between self and other perceptions of aging might be unnecessary. Theoretical and methodological implications are discussed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

The age-related decline in appetite and food intake - termed "anorexia of ageing" - is implicated in undernutrition in later life and hence provides a public health challenge for our ageing population. Eating behaviour is controlled, in part, by homeostatic mechanisms which sense nutrient status and provide feedback to appetite control regions of the brain. Such feedback signals, propagated by episodic gut hormones, are dysregulated in some older adults. The secretory responses of appetite-related gut hormones to feeding are amplified, inducing a more anorexigenic signal which is associated with reduced appetite and food intake. Such an augmented response would indicate an increase in gut sensitivity to nutrients. Consequently, this review explores the role of gastrointestinal tract nutrient sensing in age-related appetite dysregulation. We review and synthesise evidence for age-related alterations in nutrient sensing which may explain the observed hormonal dysregulation. Drawing on what is known regarding elements of nutrient sensing pathways in animal models, in other tissues of the body, and in certain models of disease, we identify potential causal mechanisms including alterations in enteroendocrine cell number and distribution, dysregulation of cell signalling pathways, and changes in the gut milieu. From identified gaps in evidence, we highlight interesting and important avenues for future research., Competing Interests: Declaration of competing interest This work was supported by a Pump Priming Award from the BBSRC/MRC funded Ageing and Nutrition Sensing Network (Principal Recipient: A.H.). The authors declare no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Oxidative stress and inflammation accompany endothelial dysfunction that results from the excessive or uncontrolled production of reactive oxygen and nitrogen species (RONS) in older adults. This study was designed to assess the usefulness of serum oxi-inflammatory component combinations in vascular disease prediction and prevention with regard to sex. Women ( n = 145) and men ( n = 50) aged 72.2 ± 7.8 years participated in this project. The females demonstrated the elevated production of hydrogen peroxide (H 2 O 2) and nitric oxide (NO) responsible for intravascular low-density lipoprotein oxidation. NO generation was enhanced in the women, but its bioavailability was reduced, which was expressed by a high 3-nitrotyrosine (3-NitroT) concentration. The relation of NO/3-NitroT (r s = 0.811, p < 0.001) in the women and NO/3-NitroT (r s = -0.611, p < 0.001) in the men showed that sex determines endothelial dysfunction. RONS generation in the women simultaneously promoted endothelial regeneration, as demonstrated by a ~1.5-fold increase in circulating progenitor cells. Inflammation-specific variables, such as the neutrophil-to-lymphocyte ratio, the systemic immune inflammation index, and the neutrophil-to-high-density lipoprotein (HDL) ratio, were reduced in the women and showed their diagnostic utility for clinical prognosis in vascular dysfunction, especially the C-reactive-protein-to-HDL ratio (AUC = 0.980, specificity 94.7%, sensitivity 93.3%, OR = 252, 95% CI 65-967, p < 0.001). This study is the first to have revealed sex-specific changes in the oxi-inflammatory response, which can generate the risk of cardiovascular events at an older age.

Aging is often linked to a decline in associative memory. Prior research has shown that older adults have difficulty retrieving specific associative memory but can retrieve gist associative memory when deliberately differentiating test pairs with different levels of specificity during associative recognition. In this study, we utilized the context reinstatement paradigm to examine whether older adults could retrieve specific memory in situations where associations do not necessarily need to be voluntarily retrieved. Thirty-five older adults were directed to intentionally link objects with unique background scenes during encoding. Subsequently, test objects were presented against either the reinstated or similar background scenes during a recognition memory task, where participants were required to identify whether the objects were old or new regardless of their background contexts. Event-related potentials (ERP) were recorded to uncover the electrophysiological correlates of specific associative episodic memory. Behavioral results revealed higher memory sensitivity for object recognition when the background scenes were reinstated than when those were similar in older adults. ERP results indicated that older adults exhibited a more prominent fronto-centrally distributed positivity during object recognition in the reinstated than in similar contexts. Our results suggest that older adults may preserve their ability to retrieve specific memory for associations through an involuntary, spontaneous recollection process, which holds important theoretical implications for age-related associative memory deficits., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The molecular mechanisms behind the potential 'anti-aging' effects of exercise remain to be elucidated. Janssens et al. studied the lipidome of different mouse tissues and human skeletal muscle. They identified an evolutionary conserved 'lipid aging' signature, characterized by bis(monoacylglycero)phosphate accumulation, which, at the muscle level, can be attenuated by exercise., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Although positive attitudes toward own aging (ATOA) have been shown to be associated with higher levels of quality of life (QoL) among older adults, the potential interrelationship between ATOA and QoL has not been fully explored. A sample of 2129 older adults aged 60 and above who participated in the three waves of the Chinese longitudinal healthy longevity survey was used. QoL was measured using three indicators, including self-rated health, loneliness, and life satisfaction. The cross-lagged analysis results showed that the bidirectional association between ATOA and QoL was not significant, while positive ATOA predicted better self-rated health, higher life satisfaction, and less loneliness. And there are no gender or age differences in the above relationships. In addition, economic status, sleep quality, and activity participation were common influences on self-rated health, life satisfaction, and loneliness, as well as important factors affecting ATOA. Several variables, such as demographic characteristics, health behaviors, and health status, also influenced QoL and ATOA. Measures to promote positive ATOA can help improve QoL. In addition, emphasis should be placed on improving economic status, sleep quality, and activity participation levels to enhance QoL and ATOA in older adults, with appropriate interventions targeting other factors affecting QoL and ATOA., (© 2024 International Association of Applied Psychology.)

This study explored the effect of weight change on successful aging in older adults. A total of 1865 adults (≥65 years) were divided into the weight gain group (weight gain ≥5 %), the weight loss group (weight loss ≥5 %), and the weight stable group (weight change <5 %) according to weight changes over 4 years. Results showed that compared to the stable weight, the weight loss is associated with a lower rate of successful aging (OR=0.64, 95 % CI: 0.49-0.83), and the association was found greater in women (OR=0.61, 95 % CI: 0.43-0.86) and young-old adults (OR=0.66, 95 % CI: 0.41-0.88) than their counterparts. However, no significant association was found between weight gain and successful aging. The findings suggest that weight loss rather than weight gain in older adults has a detrimental impact on successful aging, and this detrimental impact is greater in women and young-old adults., Competing Interests: Declaration of competing interest The authors declared no conflict of interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)

The older segment of the global population is increasing at a rapid pace. Advancements in public health and modern medicine lengthened life expectancy and reduced the burden of disease in communities worldwide. Concurrent with this demographic change is the rise in overweight people and obesity, which is evident in all age groups. There is also an aging-related reduction in muscle mass and function, or sarcopenia, that is exacerbated by sedentary lifestyle and poor nutrition. The coexistence of muscle loss and elevated body mass index, termed "sarcopenic obesity", has particularly deleterious consequences in older individuals. Worsening insulin resistance and a proinflammatory state operate at the pathophysiologic level and lead to adverse health outcomes such as a proclivity to cardiovascular disease, type 2 diabetes, and even cognitive dysfunction. Although the concept of sarcopenic obesity as a disease construct is being increasingly recognized, a clearer understanding is warranted in order to define its components and health impact. Research is needed at the molecular-cellular level to tie together derangements in insulin action, cytokines, myokines, and endothelial dysfunction with clinical outcomes. Lifestyle modifications as well as targeted nonpharmacologic approaches, such as supplements and antioxidants, appear to have a promising role in reducing the chronic burden of this emerging disorder. Breakthroughs in drug therapies that retard or even reverse the underlying dynamics of sarcopenia and obesity in older persons are being actively explored.

Purpose of Review: We reviewed recent evidence regarding the impact of climate change (specifically, high ambient temperatures, heatwaves, weather-related disasters, and air pollution) on older adults' mental health. We also summarized evidence regarding other medical problems that can occur in aging adults in connection with climate change, resulting in psychiatric manifestations or influencing psychopharmacological management., Recent Findings: Older adults can experience anxiety, depressive, and/or posttraumatic stress symptoms, as well as sleep disturbances in the aftermath of climate disasters. Cognitive deficits may occur with exposure to air pollutants, heatwaves, or post-disaster. Individuals with major neurocognitive disorders and/or preexisting psychiatric illness have a higher risk of psychiatric hospitalizations after exposure to high temperatures and air pollution. There is a growing body of research regarding psychiatric clinical presentations associated with climate change in older adults. However, there is a paucity of evidence on management strategies. Future research should investigate culturally appropriate, cost-effective psychosocial and pharmacological interventions., (© 2024. The Author(s).)

Precision medicine presents an opportunity to use novel, data-driven strategies to improve patient care. The field of precision medicine has undergone many advancements over the past few years. It has moved beyond incorporation of individualized genetic risk into medical decision-making to include multiple other factors such as unique social, demographic, behavioral, and clinical characteristics. Geriatric medicine stands to benefit heavily from the integration of precision medicine into its standard practices. Older adults, compared with other populations, have high clinical and biological heterogeneity that can alter the risks and benefits of different approaches to patient care. These factors have not been routinely considered previously by geriatricians. Yet, geriatricians' ability to address older adults' baseline heterogeneity is increasingly recognized as a cornerstone of delivering quality care in a geriatric medical practice. Given the shared focus of individualized decision-making, precision medicine is a natural fit for geriatric medicine. This manuscript provides, via cases and discussion, examples that illustrate how precision medicine can improve the care of our older patients today. We will share specific and existing tools and evidence, and review the existing multilevel barriers to further incorporate and implement these tools into clinical practice. We propose methods to address these barriers and to help realize the full potential of precision medicine for the care of older adults. We conclude with a brief discussion of potential future directions of research of precision medicine in the care of older adults., (© 2024 The American Geriatrics Society.)

We investigated the association between sedentary behavior (SB) and wish to die (WTD; i.e., feeling that one would be better off dead or wishing for one's own death), and the extent to which this can be explained by sleep problems, depression, anxiety, loneliness, perceived stress, and social network in a nationally representative sample of adults aged ≥50 years from Ireland. Cross-sectional data from Wave 1 of the Irish Longitudinal Study on Ageing 2009-2011 were analyzed. WTD was defined as answering affirmatively to the question "In the last month, have you felt that you would rather be dead?" SB was used as a continuous variable (hours/day), and also as a categorical (< or ≥8 h/day) variable. Multivariable logistic regression and mediation analyses were conducted. Data on 8163 adults aged ≥50 years were analyzed [mean (SD) age 63.6 (9.1) years; 48.0% males]. Overall, ≥8 (vs. <8) hours/day of SB was associated with a significant 2.04 (95%CI = 1.50-2.76) times higher odds for WTD, while a 1-h increase in SB per day was associated with 1.11 (95%CI = 1.06-1.16) times higher odds for WTD. Mediation analysis showed that sleep problems, depression, loneliness, perceived stress, and social network explained a modest proportion of the association between SB and WTD (mediated percentage 9.3%-14.8%). The present cross-sectional study found that increasing or higher levels of SB is positively associated with WTD. Addressing the identified potential mediators may reduce WTD among people who are sedentary. However, future longitudinal and intervention studies are needed to make concrete recommendations., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Background and Objectives: Successful aging is a mainstay of the gerontological literature, but it is not without criticism, including the often-limited way that it is studied and measured as well as the exclusion of older adults' voices in its formulation and understanding. This study sought to address these issues through a qualitative investigation across multiple countries., Research Design and Methods: This was a mixed-methods, cross-sectional, exploratory study using an online survey. Nations that received the survey included Australia, New Zealand, the United Kingdom, Ireland, Canada, and the Unites States. Participants aged 65 and older were asked to describe what successful aging means to them in an open-ended survey item. Summative content analysis was utilized to examine the responses., Results: Successful aging was defined by 1,994 participants, and 6 themes along with 20 subthemes were found. In contrast to conception that successful aging is solely or predominantly related to the absence of disease and decline, the most prominent theme in this study was "active, independent, and engaged" as the hallmark of success., Discussion and Implications: Although health and health maintenance were present in other themes, these findings support a multidimensional definition of successful aging that promotes the perspectives of older people. Future research should seek to further investigate the ways in which person-in-environment factors influence definitions of successful aging, including culture, gender and gender identity, race and ethnicity, and socioeconomic background., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.)

Background: Intrinsic capacity reflects an individual's functions and capacities across their lifetime. There are few studies on whether the level of intrinsic capacity can predict long-term mortality in Chinese populations., Objective: To explore the effects of intrinsic capacity on long-term outcomes in older Chinese adults., Methods: Data were obtained from the Beijing Longitudinal Study of Aging. Overall, 1699 community-dwelling adults aged ≥60 years were included and followed up for 8 years. Intrinsic capacity was determined according to the World Health Organization definition. The predictive ability for adverse outcomes was assessed using the age- and sex-adjusted Cox proportional hazards model., Results: A decline in intrinsic capacity domains was observed in 729 (42.9 %) participants. Declines in the mobility, cognition, vitality, sensory and psychology domains were observed in 21.8 %, 15.1 %, 11.4 %, 9.10 %, and 14.2 % of the participants, respectively. Low intrinsic capacity was associated with worse physical performance, frailty, social frailty, chronic diseases, fracture, and falls. A greater decline in intrinsic capacity predicted an elevated 8-year mortality rate (decline in overall intrinsic capacity hazard ratio 2.91, 95 % confidence interval 2.44-3.47, P < 0.001; decline in one domain hazard ratio 2.11, 95 % confidence interval 1.71-2.61, P < 0.001; decline in two domains hazard ratio 3.54, 95 % confidence interval 2.81-4.45, P < 0.001; decline in three or more domains hazard ratio 5.30, 95 % confidence interval 4.09-6.87, P < 0.001); adjusted models did not affect prediction performance. Among the five domains of intrinsic capacity, cognition was the strongest predictor of mortality (hazard ratio 3.17, 95 % confidence interval 2.63-3.81, P < 0.001)., Conclusions: Intrinsic capacity is useful in identifying older adults at higher risk of adverse outcomes, presenting significant implications for healthcare policies in China., Competing Interests: Declaration of competing interest All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Objectives: To explore whether the association between physical activity (PA) and cognition is moderated by neighbourhood disadvantage, and whether this relationship varies with age., Study Design: A longitudinal analysis of the Canadian Longitudinal Study on Aging, wherein we included participants (N = 41,599) from urban areas who did not change their residential postal code from baseline (2010-2015) to first follow-up (2015-2018)., Main Outcome Measures: At baseline, we measured PA using the Physical Activity Scale for the Elderly, and neighbourhood disadvantage using the Material and Social Deprivation Indices., Results: Using latent change score regression models, we determined that higher PA at baseline was independently associated with greater maintenance in memory performance from baseline to first follow-up both for adults aged 45-64 (B = 0.04, SE = 0.01, p = 0.001) and for those aged 65+ years (B = 0.12, SE = 0.02, p < 0.001). For participants aged 45-64 years, greater material deprivation was independently associated with declines in memory performance (B = -0.10, SE = 0.03, p < 0.001). In addition, greater social deprivation was associated with a stronger effect of PA on changes in executive functions (B = 0.17, SE = 0.08, p = 0.025) for adults aged 45-64 years; greater material deprivation was associated with a stronger effect of PA on changes in memory performance (B = 0.07, SE = 0.03, p = 0.022). We failed to detect any interactions between PA and neighbourhood disadvantage among adults aged 65+ years (all p values >0.05)., Conclusion: For middle-aged adults, the benefits of PA on cognitive performance may be strongest among adults living with greater neighbourhood social and material disadvantages. For older adults, PA may be beneficial to cognitive performance irrespective of neighbourhood disadvantages., Competing Interests: Declaration of competing interest The authors declare that they have no competing interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: As the global population ages, we witness a broad scientific and technological revolution tailored to meet the health challenges of older adults. Over the past 25 years, technological innovations, ranging from advanced medical devices to user-friendly mobile apps, are transforming the way we address these challenges, offering new avenues to enhance the quality of life and well-being of the aging demographic., Objective: This study aimed to systematically review the development trends in technology for managing and caring for the health of older adults over the past 25 years and to project future development prospects., Methods: We conducted a comprehensive bibliometric analysis of literatures related to technology-based solutions for health challenges in aging, published up to March 18, 2024. The search was performed using the Web of Science Core Collection, covering a span from 1999 to 2024. Our search strategy was designed to capture a broad spectrum of terms associated with aging, health challenges specific to older adults, and technological interventions., Results: A total of 1133 publications were found in the Web of Science Core Collection. The publication trend over these 25 years showed a gradual but fluctuating increase. The United States was the most productive country and participated in international collaboration most frequently. The predominant keywords identified through this analysis included "dementia," "telemedicine," "older-adults," "telehealth," and "care." The keywords with citation bursts included "telemedicine" and "digital health.", Conclusions: The scientific and technological revolution has significantly improved older adult health management, particularly in chronic disease monitoring, mobility, and social connectivity. The momentum for innovation continues to build, with future research likely to focus on predictive analytics and personalized health care solutions, further enhancing older adults' independence and quality of life., (©Lu Liu, Xiu-Ling Wang, Nuo Cheng, Fu-Min Yu, Hui-Jun Li, Yang Mu, Yonghui Yuan, Jia-Xin Dong, Yu-Dan Wu, Da-Xin Gong, Shuang Wang, Guang-Wei Zhang. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 20.09.2024.)

The negative portrayal of ageing as a human decline burdening society has prompted Ageing Technology industries (AgeTech) to foresee solutions rooted in the Ageing in Place paradigm. These ostensibly neutral future interventions are intertwined with socio-technical dynamics. While Science and Technology Studies (STS) and anthropology scholars have questioned these AgeTech practices, limited literature explores industry's predictions of future AgeTech. Drawing on STS and futures-anthropology literature, I interrogate AgeTech industry visions of future assemblages involving older people, smart home technology, and socio-material discourses rooted in their own discrepancies and dilemmas. To unpack AgeTech futures, my methods include a review of 49 industry reports and 29 interviews with industry experts. Based on the reports, I designed comics to be used in interviews with experts spanning CEOs and managers of companies designing technology for older people, consultants, and aged-care workers based in 12 countries. Ageing futures are far from being neutral or a chronological process, instead they are non-consensual and fragmented. In the review and interviews, I captured future assemblages of a fragmented AgeTech industry in relationships with governments and industry giants. The fragmentation continues unfolding in participants from diverse countries and professions contesting dominant AgeTech narratives. In dissecting future assemblages, I also unpack non-consensual futures based on diverging experts' values (e.g. safety versus activity) and humans' values like control and improvisation challenging predictive and surveillance technology. AgeTech Futures transcend physical matters or assemblages of technologies and humans. They encompass future normativities, tensions, divergent values, and ideological concepts. I propose not only alternatives to the visions found in industry narratives, but also encourage scholars to understand the AgeTech industry's dilemmas., Competing Interests: Declaration of competing interest None declared., (Copyright © 2024 The Author. Published by Elsevier Inc. All rights reserved.)

Objective: To assess intrarater reliability of ultrasound-determined measurements of skeletal muscle characteristics across different measurement outcomes, imaging techniques, and age groups., Methods: 2D ultrasound images (B-mode) of the quadriceps were obtained from young (26 ± 4 year, n = 8 M, 8 F) and older (70 ± 7 year, n = 7 M, 5 F) adults on two occasions, separated by 6 ± 3 days. With participants in both standing and supine postures, images were collected from five anatomical sites along the anterior (two sites) and lateral (three sites) compartments of the thigh corresponding to 56%, 39%, and 22% (lateral only) of femur length. Images were analysed for muscle thickness, pennation angle, and echogenicity. Intraclass correlation coefficients (ICC) were used to assess reliability., Results: Muscle thickness values were higher (p < 0.05) on images collected in the stand versus supine posture only for muscles of the anterior compartment, independent of age. Echogenicity values were higher (p < 0.05) in the vastus intermedius on images collected in the supine versus stand posture only in older adults. Pennation angle values were not impacted by imaging posture (p > 0.05). ICC values for thickness, echogenicity, and pennation angle were generally higher for analyses conducted on images collected in the supine versus stand posture. Imaging posture generated a greater difference in ICC values in the lateral versus anterior muscles and in older versus younger participants., Conclusion: Our findings suggest that participant posture during imaging impacts the absolute values and intrarater reliability of ultrasound-determined muscle characteristics in a muscle-specific fashion, and this effect is greater in older compared to younger individuals., (© 2024 Scandinavian Society of Clinical Physiology and Nuclear Medicine.)

Background and Objectives: Historically, aging research has focused primarily on health deterioration and negative aspects associated with aging. This has limited the scope of our understanding of the experience of aging and the relationships between aging and well-being from an integrative biopsychosocial perspective. In the same vein, there is a lack of reliable and valid assessments of aging that capture the positive aspects that characterize and improve the subjective experience of this period of life, particularly one that focuses on psychosocial well-being, including meaningful experiences and activities, group memberships, and general abilities. This study presents the development and validation of the Positive Aging Scale (PAS), a novel self-report assessment., Research Design and Methods: This was an online cross-sectional study conducted on 501 UK residents aged ≥60 years. A number of self-reported items and measures of positive aging, general health, well-being, and cognitive functioning were administered to the sample. We used exploratory and confirmatory factor analyses and assessed the dimensionality, reliability, and concurrent criterion-related validity of the PAS., Results: The results suggested that a unidimensional solution represents the data well, with the positive aging factor adequately loading on 8 items, and the solution showing factorial invariance between young-old and old participants (i.e., ≥75 years). Total PAS scores positively correlate with general health, well-being, and cognitive functioning., Discussion and Implications: The PAS demonstrated strong psychometric properties and the findings highlight correlations between the PAS and key outcomes of positive aging, including general health. Implications for research and interventions are discussed., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.)

Limited research has explored the relationship between falls, cognitive decline, and dementia onset in older adults with aging. Therefore, this study aimed to investigate the impact of cognitive function on the development of dementia and explore the association between falls and dementia among older adults. This study utilized data from the Korean Longitudinal Study of Aging, which tracked a sample group at 2-year intervals from the initial wave in 2006 to the eighth wave in 2020. Among the older adults (≥60 years) surveyed, 2829 were included in the analysis, and cognitive function and number of falls per year were recorded. We hypothesized that these variables were associated with dementia and tested the variables using dementia diagnosis data. The participants were assigned to either a dementia group (dementia diagnosis) or a control group (no dementia diagnosis). Analyses were performed to enhance generalizability of the hypothesis to all participants (≥45 years, n = 7130). Cognitive decline and dementia incidence increased with aging among older adults. The dementia group had a significantly higher rate of cognitive decline than the control group, as well as a higher number of falls and magnitude of annual changes in falls. The changes in falls were irregular regardless of cognitive function. Furthermore, falls were associated only with the development of dementia, not cognitive function. Similar trends were observed across the total participant group. Our findings highlight the importance of monitoring cognitive function and falls as potential markers for predicting dementia onset in older adults., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Older adults have difficulty maintaining balance when faced with postural disturbances, a task that is influenced by the stiffness of the triceps surae and Achilles tendon. Age-related changes in Achilles tendon stiffness have been reported at matched levels of effort, but measures typically have not been made at matched loads, which is important due to age-dependent changes in strength. Moreover, there has been limited investigation into age-dependent changes in muscle stiffness. Here, we investigate how age alters muscle and tendon stiffness and their influence on ankle stiffness. We hypothesized that age-related changes in muscle and tendon contribute to reduced ankle stiffness in older adults and evaluated this hypothesis when either load or effort were matched. We used B-mode ultrasound with joint-level perturbations to quantify ankle, muscle, and tendon stiffness across a range of loads and efforts in seventeen healthy younger and older adults. At matched loads relevant to standing and the stance phase of walking, there was no significant difference in ankle, muscle, or tendon stiffness between groups (all p > 0.13). However, at matched effort, older adults exhibited a significant decrease in ankle (27%; p = 0.008), muscle (37%; p = 0.02), and tendon stiffness (22%; p = 0.03) at 30% of maximum effort. This is consistent with our finding that older adults were 36% weaker than younger adults in plantarflexion (p = 0.004). Together, these results indicate that, at the loads tested in this study, there are no age-dependent changes in the mechanical properties of muscle or tendon, only differences in strength that result in altered ankle, muscle, and tendon stiffness at matched levels of effort., (© 2024. The Author(s) under exclusive licence to Biomedical Engineering Society.)

Introduction: The growing demographic presence of the transgender (TGD) population has sparked an increase in clinical investigations focusing on the impacts of gender-affirming hormone therapy (GAHT) in adults with gender dysphoria. Despite this surge in studies, there remains a significant gap in the literature regarding the health status of older TGD individuals. This review aims to assess prevalent pathological conditions within the TGD population, specifically concentrating on aging-related diseases investigated to date., Methods: A systematic search across Embase Ovid, Scopus, PubMed, Cochrane Library, and Web of Science databases was conducted to identify articles reporting on the aging process in TGD individuals. Methodological quality was evaluated using Newcastle-Ottawa Scale (NOS) scores., Results: Initial database searches yielded 12,688 studies, which were refined to 18 through elimination of duplicates and title/abstract review. Following a comprehensive appraisal, nine studies were included in the systematic review. These articles, published between 2017 and 2023, involved a total of 5403 participants. The evidence indicates a noteworthy percentage of the TGD population being at risk for cardiovascular diseases, experiencing depression or disability, and demonstrating hesitancy toward major recommended screening programs., Conclusions: Limited studies on older TGD individuals highlight not only an organic risk of chronic diseases but also a cognitive/psychiatric risk that should not be underestimated. Further research is imperative to deepen our understanding of the pathophysiological mechanisms involved in the health challenges faced by older TGD individuals., (© 2024. The Author(s).)

Shoulder strength is reduced in older adults but has only been assessed in planar motions that do not reflect the diverse requirements of daily tasks. We quantified the impact of age on strength spanning the three degrees of freedom relevant to shoulder function, referred to as the feasible torque space. We hypothesized that the feasible torque space would differ with age and expected this age-effect to reflect direction-specific deficits. We measured strength in 32 directions to characterize the feasible torque space of the shoulder in participants without shoulder pain or tendinous pathology (n = 39, 19-86 years). We modeled the feasible torque space for each participant as an ellipsoid, computed the ellipsoid size and direction-specific metrics (ellipsoid position, orientation, and shape), and then tested the effect of age on each metric. Age was negatively associated with ellipsoid size (a measure of overall strength magnitude; -0.0033 ± 0.0007 (Nm/kg)/year, p < 0.0001). Contrary to our expectation, the effect of age on the direction-specific metrics did not reach statistical significance. The effect of age did not differ significantly between male and female participants. Three-dimensional strength measurements allowed us to constrain the direction of participants' maximum torque production and characterize the entire feasible torque space. Our findings support a generalized shoulder strengthening program to address age-related shoulder weakness in those without pain or pathology. Clinical exam findings of imbalanced weakness may suggest underlying pathology beyond an effect of age. Longitudinal studies are needed to determine the positive or negative impact of our results., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

This study examined the interactive effect of subjective age on the relationship between global cognition and susceptibility to scams. Sixty-five participants underwent an assessment of global cognition (Mini Mental State Examination; MMSE), reported their perceived age (i.e., subjective age), and responded to a self-report questionnaire assessing scam susceptibility. A main effect of global cognition on scam susceptibility was found ( p = .028); there was no main effect of subjective age ( p = .819). An interaction between global cognition and subjective age was found ( p = .016). Examination of conditional effects demonstrated that the relationship between cognition and scam susceptibility was not significant amongst those with subjective ages below one standard deviation of the mean, but was significant for those whose subjective ages fell around or above the mean. Findings suggest that individuals with older subjective ages may be particularly vulnerable to the negative effects of lower cognition on scam susceptibility., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

The study aimed to develop and validate a gamified cognitive flexibility task through brain imaging, and to investigate behavioral and brain activation differences between young and older adults during task performance. Thirty-one young adults (aged 18-35) and 31 older adults (aged 60-80) were included in the present study. All participants underwent fMRI scans while completing the gamified cognitive flexibility task. Results showed that young adults outperformed older adults on the task. The left inferior frontal junction (IFJ), a key region of cognitive flexibility, was significantly activated during the task in both older and young adults. Comparatively, the percent signal change in the left IFJ was stronger in older adults than in young adults. Moreover, older adults demonstrated more precise representations during the task in the left IFJ. Additionally, the left inferior parietal lobule (IPL) and superior parietal lobule in older adults and the left middle frontal gyrus (MFG) and inferior frontal gyrus in young adults were also activated during the task. Psychophysiological interaction analyses showed significant functional connectivity between the left IFJ and the left IPL, as well as the right precuneus in older adults. In young adults, significant functional connectivity was found between the left IFJ and the left MFG, as well as the right angular. The current study provides preliminary evidence for the validity of the gamified cognitive flexibility task through brain imaging. The findings suggest that this task could serve as a reliable tool for assessing cognitive flexibility and for exploring age-related differences of cognitive flexibility in both brain and behavior., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Ageing and chronic stress have been linked to reduced telomere length (TL) in mixed-age groups. Whether stress response components are linked to TL during the midlife-to-late adulthood transition remains unclear. Our study aimed to synthesise evidence on the relationship between psychological and biological components of stress response on TL in middle-aged and older adults. We conducted a systematic review of studies obtained from six databases (PubMed, CINAHL, EMBASE, PsycINFO, Web of Science, and Scopus) and evaluated by two independent reviewers. Original research measuring psychological and biological components of stress response and TL in human individuals were included. From an initial pool of 614 studies, 15 were included (n = 9446 participants). Synthesis of evidence showed that higher psychological components of the stress response (i.e., global perceived stress or within a specific life domain and cognitive appraisal to social-evaluative stressors) were linked to shorter TL, specifically in women or under major life stressors. For the biological stress response, cortisol, dehydroepiandrosterone sulphate and IGF-1/cortisol imbalance, IL-6, MCP-1, blood pressure, and heart rate presented a significant association with TL, but this relationship depended on major life stressors and the stress context (manipulated vs. non-manipulated conditions). This comprehensive review showed that psychological and biological components of the stress response are linked to shorter TL, but mainly in women or those under a major life stressor and stress-induced conditions. The interaction between stressor attributes and psychological and biological reactions in the transition from middle to late adulthood still needs to be fully understood, and examining it is a critical step to expanding our understanding of stress's impact on ageing trajectories., (© 2024 The Authors. Stress and Health published by John Wiley & Sons Ltd.)

Engaging in one's neighborhood fosters independence, promotes social connectedness, improves quality of life, and increases life expectancy in older adults. There is a lack of evidence synthesis on immigrant older adults' neighborhood perceptions and experiences, essential for addressing neighborhood-level influences on aging in place. This study systematically synthesizes qualitative evidence on immigrant older adults' perceptions and experiences of their neighborhoods. A comprehensive search was conducted from inception to 5 April 2023, in multiple databases. This review considered studies including immigrant older adults aged ≥60 years, included studies from any country where the neighborhood was the focus, and only considered qualitative data while excluding review studies, theoretical publications, and protocols. Eligible studies were appraised using the JBI critical appraisal checklist for qualitative research. The Joanna Briggs Institute meta-aggregation approach was used to synthesize findings, and the ConQual approach established confidence in the synthesis. A total of 30 studies were included. Most studies were conducted in North America and explored phenomena such as aging in place, social capital, social cohesion, sense of community, and life satisfaction. Key contextual factors were walkable safe access to social spaces, accessible transportation to amenities, social cohesion with neighbors, and pre-migration neighborhood experiences. Immigrant older adults have varied experiences related to their sense of belonging and social cohesion. Factors such as racial discrimination, feeling unsafe, and social isolation contributed to negative perceptions. This review highlights the need for inclusive neighborhoods that align with the needs and values of immigrant older adults aging in place.

Background: Intrinsic capacity refers to a broad range of health traits, including the physiological and psychological changes brought on by aging. Previous research has shown that intrinsic capacity, as an independent emerging construct, is a highly effective predictor of several health outcomes., Objective: We aimed to summarise the predictive effect of intrinsic capacity at baseline on health outcomes among middle-aged and older adults., Design: A systematic review and meta-analysis., Participants: Middle-aged and older adults., Methods: We systematically searched up to 3 April 2024 in 10 electronic databases. Studies investigating the predictive effect of baseline composite intrinsic capacity and health outcomes were included. Publications that had reported hazard ratios (HRs) or odd ratios (ORs) and 95% confidence intervals (CIs) as effect size were considered., Results: A total of 23 publications were included. The sample size ranged from 100 to 17 031. The results of the meta-analysis showed statistically significant prediction of adverse health outcomes such as disability (OR = 1.84, 95% CI: 1.68-2.03, I2 = 41%, Pheterogeneity=.10), falls (OR = 1.38, 95% CI: 1.19-1.60, I2 = 45%, Pheterogeneity=.11), hospitalisation (OR = 2.25, 95% CI: 1.17-4.3, I2 = 68%, Pheterogeneity=.08), mortality (OR = 1.72, 95% CI: 1.54-1.91, I2 = 32%, Pheterogeneity=.12) and frailty (OR = 1.57, 95% CI: 1.45-1.70, I2 = 2%, Pheterogeneity=.31) by the baseline composite intrinsic capacity., Conclusions: Declined intrinsic capacity has potential predictive value for adverse health outcomes, further high-quality study is needed to validate these findings and strengthen their cumulative impact. Attention to health outcomes should also focus on both breadth and category precision., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Background: Most studies on later-life health in India focus on families, with far less attention given to the health repercussions of neighbourhood conditions among older Indians. We address this limitation in existing research by examining the associations between perceptions of neighbourhood safety and social cohesion and sleep duration and sleep quality among older adults in India., Methods: Data come from the Study on Global Aging and Adult Health (WHO-SAGE), India 2015 wave 2, with a sample of 7118 adults aged 50 years and above. Sleep quality and duration were assessed using subjective responses. Multivariable logistic and linear regression analyses were employed to test the research hypotheses., Results: Prevalence of poor sleep quality was higher among older adults living in unsafe neighbourhoods (4.46%) than peers residing in safe neighbourhoods (3.52%), and it was also higher among those living in neighbourhoods with poor social cohesion (5.31%) than counterparts who lived in socially cohesive communities (3.10%). Older adults in neighbourhoods with poor social cohesion had higher odds of reporting compromised sleep quality (adjusted odds ratio 1.75, CI: 1.22-2.51) than those living in socially cohesive neighbourhoods. Moreover, compared to those who perceived they were living in safe neighbourhoods, their peers who perceived their neighbourhoods as unsafe reported shorter sleep duration, with a negative beta coefficient of -0.27 (CI: -0.45 to -0.085)., Conclusion: That perceived unsafety and poor social cohesion within one's neighbourhood are associated with compromised sleep reflects the significance of making neighbourhoods safer and more integrated for later-life sleep health. In addition to micro-level strategies (e.g., balanced nutrition and physical activity), efforts to improve sleep health should optimise macro-level opportunities, such as rehabilitating and revitalising neighbourhoods, which may alleviate sleep disturbances and improve sleep outcomes among older adults., (© 2024 Japanese Psychogeriatric Society.)

Age-related changes pose challenges in speech processing for older adults. However, little is known about the role of auditory perceptual ability in their performance in dichotic listening tasks. The present study investigated how older adults' auditory perceptual abilities affected their correct rates and the right ear advantage (REA) in the dichotic listening tasks in two experiments. In Experiment 1, older adults' performance was assessed using dichotic listening tasks based on consonant-vowel (CV) words varying in consonants, vowels, and lexical tones, each presenting distinct auditory perceptual demands. It was found that older adults exhibited decreased correct rates as auditory perceptual demands increased. Moreover, differences in the REA were observed in older listeners, suggesting increased engagement of the hemisphere responsible for acoustic analysis in processing challenging dichotic stimuli. Experiment 2 examined how older individuals' acoustic processing abilities contributed to their dichotic listening performance. It was shown that older adults with acoustic processing abilities comparable to those of younger individuals demonstrated correct rates and REAs similar to those of younger cohorts. These results revealed the nonnegligible role of acoustic processing in the dichotic listening paradigm and the significance of considering listeners' auditory perceptual abilities in investigating language lateralisation using the dichotic listening paradigm.

Little is known about the mediating effect of attitude toward older adults on the relationship between aging knowledge and willingness to care for older adults. We applied the theory of planned behavior (TPB) and the knowledge-attitude-behavior (KAB) model as theoretical frameworks to examine the mediation effect of attitude toward older adults. Data from 388 Chinese nursing students were analyzed. The Willingness to Care for Older People (WCOP) scale, Kogan's Attitude toward Older People scale (KAOP) and Facts on Aging Quiz (FAQ) were utilized to assess willingness, attitude and aging knowledge, respectively. Data were analyzed using SPSS 22. 0 with the PROCESS macro. Bootstrap methods were used to obtain the significance of mediating effects. The study showed that aging knowledge was significantly associated with willingness to care for older adults and that attitude toward older adults mediated the association. Bootstrapping method confirmed the significance of the indirect effect of aging knowledge through attitude, accounting for 18.9% of the total willingness variance. Overall, based on the TPB and the KAB theoretical framework, our data support the notion that improving aging knowledge and attitude may contribute to improve the willingness to aged care among nursing students.

While general cognitive skills decline during aging, numerical skills seem to be mainly preserved. Such skills are essential for an independent life up to old age, e.g., when dealing with money or time. Operating with numbers usually requires number magnitude and place-value processing. The question is whether these processes are negatively affected by aging due to the general cognitive decline or positively affected due to lifelong experience with numbers. Therefore, we investigated age-related changes in the distance and compatibility effects in single-digit, two-digit, and four-digit number comparison. On the one hand, older adults took longer for number processing and showed a smaller distance effect, indicating altered number magnitude representations. On the other hand, older adults were better in place-value processing as indicated by a smaller compatibility effect than in younger adults. We conclude that aging differentially affects basic numerical skills., (© 2024. The Author(s).)

Literature suggests that dementia and, more generally, cognitive impairment affect the capacity to carry out activities of daily living (ADL) in aging. However, it is important to decipher the weight of specific cognitive domains and neurodegenerative profiles mainly related to ADL difficulties. A meta-analysis was conducted to investigate the nature and strength of the association between cognitive functioning and ADL in healthy older adults, mild cognitive impairment (MCI), and dementia. A comprehensive search of the PubMed, PsycINFO (PROQUEST), and Scopus databases for cross-sectional or longitudinal studies up until December 2022. Our meta-analytic results revealed that: overall, instrumental ADL (IADL) showed a significant association with executive functioning, in particular, abstraction ability/concept formation, set-shifting, and processing speed/complex attention/working memory, regardless of type of participants (i.e., healthy older adults, MCI, and dementia); whereas ADL (both basic ADL, BADL, and IADL) significantly correlated with global cognitive functioning and long-term verbal memory, with a moderator effect of clinical condition (e.g., increasing ES based on the level of cognitive impairment). Moreover, visuospatial and language abilities significantly correlated with ADL, mainly when performance-based tasks were used for ADL assessment. These findings emphasize the importance of neuropsychological assessment in aging to early identify people most at risk of functional decline and shed light on the need to consider specific cognitive abilities in rehabilitation programs., (© 2024. Fondazione Società Italiana di Neurologia.)

Previous research has reported mixed findings regarding age-related changes in dynamic postural stability, quantified by margin of stability (MOS), during gait. However, age-related changes in MOS may be better elicited by tasks imposing greater challenges to the postural control system. Older adults' MOS during obstacle crossing, a destabilizing task, has previously been characterized, although studies comparing MOS during this task between younger and older adults remain sparse. This study investigated age-related changes in dynamic postural stability during quiet standing, gait, and obstacle crossing. Participants aged 20-30 (n = 20), 60-69 (n = 18), 70-79 (n = 15), and 80+ (n = 7; not analyzed statistically) years old performed these tasks while whole-body motion was tracked using motion capture. MOS in each direction was estimated throughout each trial, and integrals, transient ranges, and trial minima were extracted (as applicable). MOS time series were also ensemble averaged across age groups. No age-related differences were identified for quiet standing or gait. However, obstacle crossing metrics revealed greater stability (i.e., more positive MOS) and less instability (i.e., less negative MOS) in older adults, and reduced ranges during transients. These findings potentially arise from shorter step lengths, which may be the result of age-related physical declines; or may reflect a cautious strategy in older adults, which maximizes postural stability in the direction with the greatest consequences for foot-obstacle contact, as it changes throughout the task. This study supports the use of tasks imposing physical challenges and/or voluntary perturbations to study age-related changes in dynamic postural stability. Findings also contribute to our theoretical understanding of the time course of dynamic postural stability during functional tasks in relation to periods of transition in the base of support, and task-specific strategies adopted for obstacle crossing by older adults to maintain dynamic postural stability and mitigate fall risk., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

The aim of this study was to investigate the relationships among aging self-stereotype, sense of coherence (SOC), and social isolation, as well as further explore the moderating role of cellphone use in older adults. The 817 Chinese older adults were assessed with regard to aging self-stereotypes, social isolation, SOC and cellphone use. Results from mediation analyses revealed that the negative effect of aging self-stereotype on social isolation was mediated by SOC. Moderated mediation analyses further indicated that the path from SOC to social isolation was stronger and the path from aging self-stereotype to social isolation was weaker for older adults with a higher level of cellphone use. These findings indicated that negative stereotypes were related to weaker SOC and are associated with more severe social isolation. Frequent use of cellphones can alleviate the negative effect of aging self-stereotype on social isolation and enhance the positive effect of SOC on social isolation., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.