1. Effects of Nigella sativa and albendazole alone and in combination in Toxocara canis infected mice.
- Author
-
Musa D, Senocak G, Borazan G, Altas M, Ozgonul A, Sogut O, and Güldür ME
- Subjects
- Albendazole pharmacology, Animals, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical methods, Drug Therapy, Combination, Male, Mice, Mice, Inbred BALB C, Random Allocation, Treatment Outcome, Albendazole therapeutic use, Anthelmintics therapeutic use, Nigella sativa, Phytotherapy, Plant Extracts therapeutic use, Toxocara canis, Toxocariasis drug therapy
- Abstract
Objective: Nigella sativa extract has been used in the Middle East as a traditional medicine for several complaints. We aimed to evaluate the biochemical, histopathological and hematologic changes in Toxocara canis-infected mice after treatment with Nigella sativa extract, albendazole or a combination of both., Methods: This comparative study was conducted between June and July 2008 at the Itarran University Saniturla Turkey. Sixty healthy adult BALB/c male mice were randomly divided into six groups (D0-D5). Mice in groups D1-D5 received 500 embryonated T. canis eggs via esophageal tube. Groups DO and D1 served as a non-infected sham group and an infected control group, respectively. Groups D2 and D3 received 100 and 200 mg/kg N. sativa extract (NSE), respectively. Group D4 received 100 mg/kg albendazole. Group D5 received the combination dose (100+100 mg/kg NSE+albendazole)., Results: Treatment with N. sativa of both doses or the combination dose of N. sativa and albendazole reduced the degree of inflammation and necrosis, lead to a reduction in the percentage of eosinophils and decreased the elevated liver enzyme levels., Conclusion: These results indicate that N. sativa has a potent effect in protection against organ damage induced by T. canis infection.
- Published
- 2011