1. Five undescribed guanidine alkaloids from Plumbago zeylanica.
- Author
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Zheng L, Guo PJ, Zhu Y, Li CY, Wang WQ, and Xuan LJ
- Subjects
- Guanidines chemistry, Guanidines isolation & purification, Guanidines pharmacology, Molecular Structure, Plant Roots chemistry, RAW 264.7 Cells, Animals, Mice, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacology, Nitric Oxide metabolism, Macrophages drug effects, Magnetic Resonance Spectroscopy, Alkaloids chemistry, Alkaloids isolation & purification, Alkaloids pharmacology, Plumbaginaceae chemistry
- Abstract
Five undescribed guanidine alkaloids, plumbagines HK (1-4) and plumbagoside E (5), as well as five known analogues (6-10) were isolated from the roots of Plumbago zeylanica. Their structures were established by extensive spectroscopic analyses and chemical methods. In addition, 1-10 were accessed their anti-inflammatory activities by measuring nitric oxide (NO) concentrations in LPS-induced RAW 264.7 cells. However, all compounds especially 1 and 3-5 could not inhibit the secretion of NO but significant increase the secretion of NO. The result reminded us that 1-10 may become potential novel immune potentiators., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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