1. Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index
- Author
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Nicole Donato, Francesco Di Campli, Stefano Ferracuti, Elisabetta Teti, Alfredo Pennica, Antonio Aceti, Claudio Del Percio, Giuseppe Noce, Cristina Limatola, Paolo Onorati, Susanna Cordone, Claudio Babiloni, Massimo Andreoni, Magdalena Viscione, Chiara Muratori, Laura Gianserra, and Andrea Soricelli
- Subjects
Male ,medicine ,HIV Infections ,Pilot Projects ,Audiology ,Electroencephalography ,delta/alpha power density ,0302 clinical medicine ,EEG ,Cerebral Cortex ,Delta/alpha power density ,Human immunodeficiency virus (HIV) ,Low-resolution brain electromagnetic source tomography (LORETA) ,Resting-state electroencephalography (EEG) ,Z-score ,Adult ,Humans ,Viral Load ,Rest ,human immunodeficiency virus ,medicine.diagnostic_test ,05 social sciences ,low-resolution brain electromagnetic source tomography ,LORETA ,Sensory Systems ,medicine.anatomical_structure ,Neurology ,Cerebral cortex ,Psychology ,Viral load ,medicine.medical_specialty ,Settore MED/17 - Malattie Infettive ,resting-state electroencephalography ,Alpha (ethology) ,Standard score ,050105 experimental psychology ,03 medical and health sciences ,Rhythm ,Physiology (medical) ,0501 psychology and cognitive sciences ,Resting state fMRI ,HIV ,adult ,cerebral cortex ,electroencephalography ,HIV infections ,humans ,male ,pilot projects ,viral load ,rest ,sensory systems ,neurology ,physiology ,Standard error ,Neurology (clinical) ,Neuroscience ,030217 neurology & neurosurgery - Abstract
This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (4 Hz) and alpha (8-13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status.Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p0.05).This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.
- Published
- 2016