1. Reassessing the pathogenicity of c.2858G>T(p.(G953V)) in COL4A5 Gene: report of 19 Chinese families
- Author
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Xuhui Zhong, Jie Ding, Suxia Wang, Fang Wang, Hongwen Zhang, Ke Xu, Yanqin Zhang, and Xiaoyu Liu
- Subjects
Adult ,Collagen Type IV ,Male ,0301 basic medicine ,Proband ,congenital, hereditary, and neonatal diseases and abnormalities ,Adolescent ,PAX2 ,Mutation, Missense ,030232 urology & nephrology ,Nephritis, Hereditary ,Biology ,urologic and male genital diseases ,medicine.disease_cause ,Asymptomatic ,Article ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,Missense mutation ,Alport syndrome ,skin and connective tissue diseases ,Child ,Gene ,Genetics (clinical) ,Mutation ,Genetic counselling ,Disease genetics ,Infant ,Middle Aged ,medicine.disease ,Phenotype ,female genital diseases and pregnancy complications ,Pedigree ,030104 developmental biology ,Child, Preschool ,Female ,medicine.symptom - Abstract
X-linked Alport syndrome (XLAS) is an inherited renal disease caused by mutations inCOL4A5gene. The c.2858G>T(p.(G953V)) inCOL4A5gene (rs78972735) has been considered pathogenic previously. However, there are conflicting interpretations of its pathogenicity recently. Here we presented 19 Chinese families, out of which 36 individuals (18 probands and 18 family members) carried the c.2858G>T(p.(G953V)) inCOL4A5gene. The clinical manifestations and genetic findings of them were analyzed. We found there were no clinical features of Alport syndrome not only in six probands with c.2858G>T(p.(G953V)) inCOL4A5plus pathogenic variants in other genes (e.g.,WT1,ADCK4,NPHP1,TRPC6,COL4A4,andPAX2) but also in another six probands with only the c.2858G>T(p.(G953V)) variant. The other six probands with a combination of c.2858G>T(p.(G953V)) and another pathogenic variant inCOL4A5had XLAS. Eleven family members (11/18, nine females and two males) who had only the c.2858G>T(p.(G953V)) variant were asymptomatic. These two males (at age of 42 and 35 years) had normal result of urine analysis and no more clinical traits of Alport syndrome. We conclude c.2858G>T(p.(G953V)) inCOL4A5gene is not a pathogenic variant for XLAS. Individuals should not be diagnosed as XLAS only based on the detection of c.2858G>T(p.(G953V)) inCOL4A5gene.
- Published
- 2019