1. Synthesis and biological screening of aminothiadiazine dioxides related to trimethoprim.
- Author
-
Alkorta I, Goya P, Nombela C, Medina R, and Pérez Martín C
- Subjects
- Animals, Anti-Bacterial Agents, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Bacteria drug effects, Candida albicans drug effects, Cattle, Folic Acid Antagonists, Liver enzymology, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Thiadiazines chemistry, Thiadiazines pharmacology, Trimethoprim chemical synthesis, Trimethoprim pharmacology, Anti-Infective Agents chemical synthesis, Thiadiazines chemical synthesis, Trimethoprim analogs & derivatives
- Abstract
New derivatives of 3-amino-1,2,6-thiadiazine 1,1-dioxide have been synthesized and their antibacterial, antifungal and DHFR inhibitory activities evaluated. Their chemical structures have been established by means of analytical and NMR spectroscopic data. Among the compounds studied, the 4,4-dibromo derivative 11 showed fungistatic activity against C. albicans.
- Published
- 1991