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Your search keyword '"Ueda, Yasutsugu"' showing total 4 results
Start Over Author "Ueda, Yasutsugu" Topic antibacterial activity
4 results on '"Ueda, Yasutsugu"'

1. Synthesis and antibacterial activity of nocathiacin I analogues

Author

Naidu, B. Narasimhulu, Sorenson, Margaret E., Matiskella, John D., Li, Wenying, Sausker, Justin B., Zhang, Yunhui, Connolly, Timothy P., Lam, Kin S., Bronson, Joanne J., Pucci, Michael J., Yang, Hyekyung, and Ueda, Yasutsugu

Subjects
*ORGANIC acids, *SOLUTION (Chemistry), *AMINES, *AMIDES
Abstract

Abstract: Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility. [Copyright &y& Elsevier]

Published
2006
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2. Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts

Author

Naidu, B. Narasimhulu, Sorenson, Margaret E., Bronson, Joanne J., Pucci, Michael J., Clark, Junius M., and Ueda, Yasutsugu

Subjects
*ANTIBACTERIAL agents, *THIOLS, *ANTI-infective agents, *ACIDS
Abstract

Abstract: The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4–20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity. [Copyright &y& Elsevier]

Published
2005
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4. Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives

Author

Naidu, B. Narasimhulu, Sorenson, Margaret E., Hudyma, Thomas, Zheng, Xiaofan, Zhang, Yunhui, Bronson, Joanne J., Pucci, Michael J., Clark, Junius M., and Ueda, Yasutsugu

Subjects
*ANTIBACTERIAL agents, *NATURAL products, *COMMERCIAL products, *WATER
Abstract

The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1–12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7–9 also exhibited potent in vivo activity. [Copyright &y& Elsevier]

Published
2004
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