1. A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water.
- Author
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Kobayashi Y, Murata K, Harada A, and Yamaguchi H
- Subjects
- Allyl Compounds chemical synthesis, Allyl Compounds chemistry, Amination, Animals, Antibodies, Monoclonal immunology, Antibodies, Monoclonal metabolism, Benzylamines chemical synthesis, Benzylamines chemistry, Catalysis, Cattle, Coordination Complexes immunology, Coordination Complexes metabolism, Cross Reactions immunology, Female, Gastropoda chemistry, Hemocyanins chemistry, Mice, Inbred BALB C, Protein Binding, Rhodium chemistry, Serum Albumin, Bovine chemistry, Stereoisomerism, Water chemistry, Antibodies, Monoclonal chemistry, Coordination Complexes chemistry, Palladium chemistry
- Abstract
We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).
- Published
- 2020
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