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Your search keyword '"Iijima, Mariko"' showing total 1 results
Start Over Author "Iijima, Mariko" Topic antibody engineering
1 results on '"Iijima, Mariko"'

1. Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies.

Author

Lee, Young-Hun, Iijima, Mariko, Kado, Yuji, Mizohata, Eiichi, Inoue, Tsuyoshi, Sugiyama, Akira, Doi, Hirofumi, Shibasaki, Yoshikazu, and Kodama, Tatsuhiko

Subjects
*MONOCLONAL antibodies, *EPIREGULIN, *EPIDERMAL growth factor, *CELL-mediated cytotoxicity, *COLON cancer treatment, *CANCER cells, *ANTIGEN-antibody reactions
Abstract

Highlights: [•] Epiregulin may be highly relevant for therapeutic applications. [•] We generated humanized anti-epiregulin antibodies by resurfacing the variable region. [•] Our method identified residues that critically affect antigen binding. [•] Our HM1 antibody had high-affinity targeted cytotoxicity against colon cancer cells. [ABSTRACT FROM AUTHOR]

Published
2013
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