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Start Over Author "Lou, Huiping" Topic anticancer
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1. A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49–57 with cytotoxic and apoptotic effects against human cancer cells

Author

Lou, Huiping, Gao, Yanfeng, Zhai, Mingxia, Qi, Yuanming, Chen, Lixiang, Lv, Hong, Yu, Jibing, and Li, Yongxin

Subjects
*CANCER cells, *CELL culture, *APOPTOSIS, *CELL lines
Abstract

Abstract: A series of novel peptides from various motifs of Asterina pectinifera cyclin B and their derivatives conjugated to HIV-Tat49–57 were designed and synthesized. Their bioactivities on two human cancer cell lines were determined. Among them, Tat-a5 (KAQIRAMECNILGRKKRRQRRR) exhibited significant cytotoxic effects on cancer cell lines EC-9706 and HCT-116. Tat-a5 could arrest cancer cells at G2/M phase and make them apoptotic. Our results suggested that Tat-a5 could be a novel leading peptide with anticancer activity. [Copyright &y& Elsevier]

Published
2008
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