1. Plant Antimicrobial Peptides (PAMPs): Features, Applications, Production, Expression, and Challenges
- Author
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Olalekan Olanrewaju Bakare, Arun Gokul, Adewale Oluwaseun Fadaka, Ruomou Wu, Lee-Ann Niekerk, Adele Mariska Barker, Marshall Keyster, and Ashwil Klein
- Subjects
Crops, Agricultural ,Anti-Infective Agents ,Chemistry (miscellaneous) ,Organic Chemistry ,Drug Discovery ,Pathogen-Associated Molecular Pattern Molecules ,Molecular Medicine ,Pharmaceutical Science ,Animals ,Physical and Theoretical Chemistry ,Antimicrobial Peptides ,Analytical Chemistry ,Antimicrobial Cationic Peptides - Abstract
The quest for an extraordinary array of defense strategies is imperative to reduce the challenges of microbial attacks on plants and animals. Plant antimicrobial peptides (PAMPs) are a subset of antimicrobial peptides (AMPs). PAMPs elicit defense against microbial attacks and prevent drug resistance of pathogens given their wide spectrum activity, excellent structural stability, and diverse mechanism of action. This review aimed to identify the applications, features, production, expression, and challenges of PAMPs using its structure–activity relationship. The discovery techniques used to identify these peptides were also explored to provide insight into their significance in genomics, transcriptomics, proteomics, and their expression against disease-causing pathogens. This review creates awareness for PAMPs as potential therapeutic agents in the medical and pharmaceutical fields, such as the sensitive treatment of bacterial and fungal diseases and others and their utilization in preserving crops using available transgenic methods in the agronomical field. PAMPs are also safe to handle and are easy to recycle with the use of proteases to convert them into more potent antimicrobial agents for sustainable development.
- Published
- 2022