1. Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries.
- Author
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Guo, Ruixue, Guo, Xinbo, Li, Tong, Fu, Xiong, and Liu, Rui Hai
- Subjects
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ANTIOXIDANTS , *SEA buckthorn , *ANTINEOPLASTIC agents , *PHYTOCHEMICALS , *AGLYCONES , *QUERCETIN , *THERAPEUTICS - Abstract
Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn ( Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7 ± 1.3 mg GA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp . yunnanensis . Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC 50 ) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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