1. Synthesis of substituted terpyridine nickel nitrate complexes and their inhibitory selectivity against cancer cell lines.
- Author
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Huang X, Wang B, Sun D, Chen M, Xue X, Liu H, Zhou Y, and Ma Z
- Subjects
- Humans, Cell Line, Tumor, Cell Proliferation drug effects, Nitrates chemistry, Nitrates pharmacology, Crystallography, X-Ray, Nickel chemistry, Coordination Complexes pharmacology, Coordination Complexes chemical synthesis, Coordination Complexes chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Pyridines chemistry, Pyridines pharmacology
- Abstract
Six terpyridine‑nickel complexes 1-6 were formed by the coordination of 4'-(4-R-phenyl)-2,2':6',2″-terpyridine (R = hydroxyl (L
1 ), methoxyl (L2 ), methylsulfonyl (L3 ), fluoro (L4 ), bromo (L5 ), iodo (L6 )) derivatives to nickel nitrate. The compositions and structures of these complexes were analyzed by Fourier Transform infrared spectroscopy (FT-IR), elemental analyses, electrospray ionization mass spectra (ESI-MS), solid-state ultraviolet-visible (UV-Vis) spectroscopy, and single crystal X-ray diffraction (1, 2 and 4) studies. In vitro anticancer cell proliferation experiments against SiHa (human cervical squamous cancer cell line) cells, Bel-7402 (human hepatoma cancer cell line), Eca-109 (human esophageal cancer cell line) and HL-7702 (human normal hepatocyte cell line) indicate that they have more excellent anti-proliferation effects than the cis-platin against Siha cells, Bel-7402 cells and Eca-109 cells. Especially, complex 5 showed a rather outstanding inhibitory effect against the SiHa cell line and was less toxic than the other compounds to the HL-7702 cell line, implying an obvious specific inhibitory effect. Therefore, complex 5 has the potential value to be developed as an anticancer cell-specific drug against human cervical squamous carcinoma. Molecular docking simulation, UV-vis absorption spectroscopy and circular dichroism experiments show that they prefer to bind to DNA part in an embedded binding manner., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Inc.)- Published
- 2024
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