1. A new steroidal glycoside from the fruits of Solanum myriacanthum .
- Author
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Ono M, Shimode M, Tsutsumi S, Yasuda S, Okawa M, Kinjo J, Miyashita H, Ikeda T, Yoshimitsu H, and Nohara T
- Subjects
- Fruit, Glycosides pharmacology, Humans, Alkaloids, Antineoplastic Agents, Saponins, Solanum
- Abstract
A new cholestane-type steroidal glycoside, solamyriaside A ( 1 ), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A ( 2 ) and aculeatiside A ( 3 ), and three known steroidal alkaloid glycosides, namely, solamargine ( 4 ), khasianine ( 5 ) and solasonine ( 6 ), which were isolated for the first time from this plant. Based on spectroscopic data as well as chemical evidence, 1 was determined to be 3- O -α-L-rhamnopyranosyl-(1→2)- O -[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-22 R ,25 R -cholest-5-ene-3β,16α,22,26-tetraol 26- O -β-D-glucopyranoside. The cytotoxic activity of 1 - 6 against HL-60 human promyelocytic leukaemia cells was examined. Compounds 4 - 6 showed cytotoxic activity. Among them, 4 exhibited the strongest activity with an IC
50 value of 4.64 ± 0.17 μM, similar to the activity of cisplatin, a positive control.- Published
- 2022
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