1. An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery.
- Author
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He M, Fan M, Peng Z, and Wang G
- Subjects
- Anti-Infective Agents chemistry, Anti-Inflammatory Agents chemistry, Antineoplastic Agents chemistry, Antioxidants chemistry, Drug Discovery, Humans, Hypoglycemic Agents chemistry, Pyrans chemistry, Pyrans pharmacology, Pyridones chemistry, Pyridones pharmacology, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Antineoplastic Agents pharmacology, Antioxidants pharmacology, Hypoglycemic Agents pharmacology
- Abstract
Hydroxypyranone and hydroxypyridinone are important oxygen-containing or nitrogen-containing heterocyclic nucleus and attracted increasing attention in medicinal chemistry and drug discovery over the past decade. Previous literature reports revealed that hydroxypyranone and hydroxypyridinone derivatives exhibit a wide range of pharmacological activities such as antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, antioxidant, anticonvulsant, and anti-diabetic activities. In this review, we systematically summarized the literature reported biological activities of hydroxypyranone and hydroxypyridinone derivatives. In particular, we focus on their biological activity, structure-activity relationship (SAR), mechanism of action, and interaction mechanisms with the target. The collected information is expected to provide rational guidance for the development of clinically useful agents from these pharmacophores., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
- Published
- 2021
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