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Your search keyword '"Lim, Joo Hyuck"' showing total 2 results
Start Over Author "Lim, Joo Hyuck" Topic ascorbic acid
2 results on '"Lim, Joo Hyuck"'

1. Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation.

Author

Kim MK, Shin MH, Lim JH, Bae JS, Lee YR, Shin HS, Cho SI, Chung JH, and Lee DH

Subjects
Antioxidants chemistry, Ascorbic Acid chemistry, DNA (Cytosine-5-)-Methyltransferase 1 antagonists & inhibitors, DNA (Cytosine-5-)-Methyltransferase 1 metabolism, DNA Methylation drug effects, Enzyme Assays, Extracellular Matrix drug effects, Extracellular Matrix metabolism, Fibroblasts, HEK293 Cells, Humans, Oligopeptides chemistry, Skin cytology, Skin drug effects, Skin Aging genetics, Antioxidants administration & dosage, Ascorbic Acid administration & dosage, Epigenesis, Genetic drug effects, Oligopeptides administration & dosage, Skin Aging drug effects
Abstract

Competing Interests: Declaration of Competing Interest No conflict of interest declared.

Published
2021
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2. Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation.

Author

Kim HM, An HS, Bae JS, Kim JY, Choi CH, Kim JY, Lim JH, Choi JH, Song H, Moon SH, Park YJ, Chang SJ, and Choi SY

Subjects
Adult, Cell Line, Female, Humans, Middle Aged, Skin drug effects, Skin physiopathology, Skin Aging physiology, Ascorbic Acid analogs & derivatives, Ascorbic Acid pharmacology, Collagen biosynthesis, Oligopeptides pharmacology, Skin Aging drug effects, Skin Lightening Preparations pharmacology
Abstract

Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1-4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.

Published
2017
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