1. Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1.
- Author
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Zekeridou A, Yang B, Lennon VA, Guo Y, Wu L, Lucchinetti CF, McKeon A, Pittock SJ, and Flanagan EP
- Subjects
- Animals, Female, Humans, Male, Middle Aged, Autoantigens, Biomarkers, Immunoglobulin G, Autoimmunity, Neoplasms
- Abstract
The antigen specificity of Anti-Neuronal Nuclear Antibody-type 3 (ANNA3)-IgG is unknown. We identified Dachshund-homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen-specific assays, immunohistochemical colocalization and immune absorption experiments. Patients' median age was 63.5 years (range, 49-88); 67% were female. Neurological manifestations (information available for 30 patients) included one or more of neuropathy, 12; cognitive difficulties, 11; ataxia, 8; dysautonomia, 7. Evidence of a neoplasm was present in 27 of 30 (90%), most of neuroendocrine lineage. DACH1-IgG is rare and represents a novel proposed biomarker of neurological autoimmunity and cancer. ANN NEUROL 2022;91:670-675., (© 2022 American Neurological Association.)
- Published
- 2022
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