Search

Your search keyword '"Crépy K"' showing total 1 results
Start Over Author "Crépy K" Topic benzoxazines

Refine your results

1 results on '"Crépy K"'

1. Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.

Author

Perry B, Alexander R, Bennett G, Buckley G, Ceska T, Crabbe T, Dale V, Gowers L, Horsley H, James L, Jenkins K, Crépy K, Kulisa C, Lightfoot H, Lock C, Mack S, Morgan T, Nicolas AL, Pitt W, Sabin V, and Wright S

Subjects
Area Under Curve, Benzoxazines pharmacology, Crystallography, X-Ray methods, Drug Design, Humans, Inflammation, Inhibitory Concentration 50, Models, Chemical, Molecular Structure, Protein Isoforms, Structure-Activity Relationship, Benzoxazines chemistry, Chemistry, Pharmaceutical methods, Oxazines chemical synthesis, Oxazines pharmacology, Phosphatidylinositol 3-Kinases metabolism
Abstract

The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results