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Cichoriumintybus L., often known as chicory, is a Mediterranean plant species that is a member of the Asteraceae family. It has been known to have therapeutic benefits for a very long time. C. intybus is unique among the six species of Cichorium that are grown in Europe and Asia because of its wide range of uses in conventional medicine. The plant has been used in many traditional medical systems, especially in India, where it has been used to treat a wide range of illnesses, from diabetes to wounds. Chicory contains a wide range of phytoconstituents, including cellulose, proteins, sugar, flavonoids, polyphenols, carotenoids, anthocyanins, tannins, coumarins, sesquiterpene lactones, fatty acids, cholins, benzo-isochromenes, alkaloids, vitamins, and minerals. The diverse ranges of therapeutic benefits associated with C. intybus are partly ascribed to this phytochemical composition. The pharmacological actions of chicory, which have been demonstrated to range from hepatoprotective to anti-inflammatory, demonstrate the plant's versatility and its potential to treat a variety of illnesses. This article offers a thorough investigation of C. intybus L.'s phytochemistry and pharmacological applications. This review attempts to be a useful resource for researchers, medical professionals, and practitioners interested in using Cichoriumintybus's medicinal properties for improving human health by compiling the body of knowledge on the botanical and chemical aspects of chicory as well as its therapeutic applications. [ABSTRACT FROM AUTHOR]

The agonising disorder known as dysmenorrhea, which is characterized by painful menstruation, affects women all over the world. Due to their apparent efficacy and lack of side effects, traditional and herbal treatments for the management of dysmenorrhea have attracted increasing interest in recent years. The goal of this review is to offer a thorough examination of the most recent scientific research on the use of herbal remedies for the treatment of dysmenorrhea. We thoroughly investigate a wide range of medicinal plants, their active ingredients, their modes of action, and the clinical data demonstrating their effectiveness. This review emphasises the potential of medicinal plants as alternative or complementary options for the management of dysmenorrhea through an in-depth examination of botanical interventions. The dearth of comprehensive clinical trials and disparities in study design, however, highlight the need for more investigation into the safety and effectiveness of these therapies. This study provides a helpful resource for healthcare professionals, researchers, and individuals looking for alternative methods to lessen the burden of dysmenorrhea by highlighting the knowledge gaps now in existence and providing insights into prospective future research areas. [ABSTRACT FROM AUTHOR]

Natural sweetener honey has been valued for generations for its delectable flavor and therapeutic benefits. This mini-review examines the various medicinal advantages of the bioactive substances present in honey. Although sugars are the main component of honey, it also contains a variety of secondary metabolites, including phenolic chemicals, flavonoids, enzymes, and peptides. The antioxidant, anti-inflammatory, antibacterial and wound-healing effects of honey are a result of these bioactive substances. Traditional medicine has used honey to cure a variety of illnesses, and modern scientific investigations have offered strong evidence in favor of honey's therapeutic potential. In order to highlight honey's promising potential as a natural medicine, this article provides an overview of the present level of knowledge on its bioactive chemicals and their applications in human health. [ABSTRACT FROM AUTHOR]

This systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy that arises from the dysregulation of cell differentiation, proliferation, and cell death. The risk factors associated with the onset of AML include long‐term exposure to radiation and chemicals such as benzene, smoking, genetic disorders, blood disorders, advancement in age, and others. Although novel strategies to manage AML, including a refinement of the conventional chemotherapy regimens, hypomethylating agents, and molecular targeted drugs, have been developed in recent years, resistance and relapse remain the main clinical problems. In this study, three databases, PubMed/MEDLINE, ScienceDirect, and Google Scholar, were systematically searched to identify various bioactive compounds with antileukemic properties. A total of 518 articles were identified, out of which 59 were viewed as eligible for the current report. From the data extracted, over 60 bioactive compounds were identified and divided into five major groups: flavonoids, alkaloids, organosulfur compounds, terpenes, and terpenoids, and other known and emerging bioactive compounds. The mechanism of actions of the analyzed individual bioactive molecules differs remarkably and includes disrupting chromatin structure, upregulating the synthesis of certain DNA repair proteins, inducing cell cycle arrest and apoptosis, and inhibiting/regulating Hsp90 activities, DNA methyltransferase 1, and histone deacetylase 1. [ABSTRACT FROM AUTHOR]

Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: "Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases. [ABSTRACT FROM AUTHOR]