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Coordinated Cell Motion In article number 2104808 by Swetha Raghuraman, Timo Betz, and co‐workers, a novel migration phenomenon is presented wherein cancer cells burst out from tumor aggregates as an act of pressure release into the surrounding in‐homogeneous soft extra‐cellular matrix (ECM) made up of collagen. The pressure within tumor aggregates manifests due to cellular swelling, leading to a super‐diffusive coordinated expulsion of cells within 12 hours, directed towards regions providing least mechanical resistance [Image: see text]

Colon Mucosa Protecting HA‐Enema System In article number 2103189, Yury Rochev, Abhay Pandit, and co‐workers develop a biphasic HMW‐hyaluronan (HA) enema suspension that protects the dysregulated colitis colon epithelium. The developed HA‐based system modulate the intestinal epithelial junctional proteins and regulatory signalling pathways, resulting in attenuation of inflammation and mucosal protection. Furthermore, the developed system helps restore the dysregulated intestinal barrier functions and helps in distal colitis management. [Image: see text]

Translational Bioinks for 3D Bioprinting 3D‐Bioprinting, a technology at the interface of additive manufacturing, biomaterials and cell biology, is poised to revolutionize regenerative medicine and drug screening. Bioinks are the lynchpin as they bridge bench to bedside. A biology‐based approach to engineering bioinks with pro‐regenerative attributes, with an emphasis on reproducibility, efficiency, and conformance to regulatory standards is essential for paving the way to clinical translation. More details can be found in article number 2103469 by V. Prasad Shastri and co‐workers. [Image: see text]

Transverse Laser Modes In article number 2103550 by Changjin Huang, Yu‐Cheng Chen, and co‐workers, the key mechanism governing the frequency distributions of transverse modes in single cell biological lasers are revealed. The cover art illustrates the concept of distinctive laser fingerprints generated by cells, which could be employed to provide cellular information. Morphological information of cells could be interpreted through hyperspectral imaging of laser modes. Applications including cell classification and monitoring of cell adhesion are explored and demonstrated. [Image: see text]

LectinOracle In article number 2103807, Daniel Bojar and co‐workers develope a generalizable deep learning platform for predicting and understanding protein‐carbohydrate interactions, LectinOracle. Combining information from protein and carbohydrate sequences, LectinOracle can predict interactions for new proteins and new carbohydrates or glycans. This has been used for many purposes, such as understanding interactions in the microbiome or predicting epidemiological outcomes. [Image: see text]

Macrophage‐Myofibroblast Transition In article number 2101235 Philip Chiu‐Tsun Tang, Patrick Ming‐Kuen Tang, Hui‐Yao Lan, and co‐workers discovered that tumor‐associated macrophages are capable for de novo generating pathogenic cancer‐associated fibroblasts via a direct mechanism macrophage‐myofibroblast transition (MMT), representing a novel therapeutic target in the tumor microenvironment of solid cancers. Here, the macrophages undergoing MMT were coexpressing CAF (α‐SMA, red) and macrophage marker (F4/80, green) with nuclei staining (blue), visualized by immunofluorescence with an experimental Lewis lung carcinoma (LLC) model. [Image: see text]

Maternal Benzophenone Exposure In article number 2102686 by Shunqing Xu, Yaohui Tang, Xia Sheng, and co‐workers, it is reported that maternal exposure to benzophenone and its major metabolite 4‐hydroxybenzophenone during pregnancy causes endoplasmic reticulum proteotoxicity and neuroinflammation, which lead to cognitive dysfunction and neurodevelopmental toxicity in offspring mice. This alerts that the excessive use of personal care products during pregnancy may impair child's neurodevelopment. [Image: see text]

Two‐Way Shape‐Memory Aerogels In article number 2102674, Meng Wang, Hong Yang, Quan Li and co‐workers report the design, synthesis, characterization and reversible deformation of an unprecedented two‐way shape‐memory liquid crystal elastomer (LCE)‐based aerogel. The LCE‐based aerogel, prepared by an orthogonal thermal and photo curing strategy coupled with an intermediate mechanical stretching step, exhibits reversible shrinking/expansion deformation during heating/cooling cycles with superior fatigue resistance. Cover story depicts Bull Demon King, a famous monster in the traditional Chinese novel Journey to the West, taking back the magic weapon plantain fan (LCE‐based aerogel) in his territory, Flaming Mountain (external stimulus). [Image: see text]

Molecular Heterojunction In article number 2101390 by Gunuk Wang and co‐workers, a tailored molecular heterojunction selector is implemented by controlling its interfacial band offset. Based on diverse interfacial band offsets achieved by changing the heterojunction constituents, such as the molecular dipole moment direction, types of two‐dimensional transition metal dichalcogenide, and work function of the electrodes, the nonlinearity is widely tuned. The suggested molecular heterojunction selector is depicted in array and binary numbers. [Image: see text]

Human Brain Model In article number 2101251 by Hansang Cho and co‐workers, PM2.5‐polluted human brain models (PMBs) are created in a 3D microfluidic platform reconstituting key aspects of human brain immunity under the PM2.5 exposure. The cover artwork shows the potential risk of neuroinflammation on brain health induced by air pollutants from diesel exhaust. Cover illustration by You Jung Kang. CT images of organs kindly provided by NIH. [Image: see text]

Photoelectrochemical Solar Water Splitting In article number 2102458 by Ho Won Jang, Jooho Moon, and co workers, performance bias‐free solar water splitting is reported. Sulfur precursor with a weak dipole moment produces high‐quality dense SnS nanoplates with enlarged favorable crystallographic facets, suppressing anisotropic growth. Ga(2)O(3) interlayered SnS photocathode efficiently improves charge transport kinetics without charge trapping. The high‐performance SnS photocathode represents a promising platform for photoelectrochemical solar water splitting. [Image: see text]

van der Waals SnI(2) Monolayers In article number 2100009, Ping Zhang, Shao‐Chun Li, and co‐workers demonstrate the direct growth of van der Waals SnI(2) monolayer, a new semiconducting material. The SnI(2) monolayer exhibits a band gap of 2.9 eV, and an indirect‐ to direct‐band gap transition occurs in the SnI2 bilayer, suggesting its potential application in future electronics/optoelectronics. [Image: see text]

Proteolysis‐Targeting Chimera Technology In article number 2102555, Hong‐yu Li, Haojie Huang, and co‐workers demonstrate a new approach, oligonucleotide‐based proteolysis‐targeting chimera (O'PROTAC), to degrade “undruggable” transcriptional factors (TFs) via the ubiquitin‐proteasome system. O'PROTAC is designed by employing the TF‐uniquely‐recognized DNA sequence as natural “ligand”. The programmability of O'PROTAC makes it an attractive arsenal to target TFs for treatment of diseases including cancer. [Image: see text]

Humanized Biomimetic Nanovesicles In article number 2101437, Assaf Zinger, Francesca Taraballi, Robert Krencik, and co‐workers optimize and validate the scalable production of neuron‐targeting biomimetic nanovesicles (NV) with distinct lipid backbones suited to potential therapeutic cargo by integrating membrane proteins from human pluripotent stem cell‐derived neurons. NVs with neuronderived membrane proteins exhibit enhanced neuronal association and uptake compared to bare NVs. These customizable NVs enable next‐generation functionalized theranostics for neurodegeneration. [Image: see text]

Lithium‐Ion Batteries In article number 2101646, Jianhui Wang, Atsuo Yamada and co‐workers report salt‐concentrated electrolytes can overcome various challenges for lithium‐ion full cells that operate in a wide temperature range from ‐20 to 100 °C. This achievement contributes to building a novel power battery pack that requires no thermal management system and deliveries greatly enhanced systematic energy densities in both gravimetry and volumetry. [Image: see text]

Regulating Cardiomyocyte Differentiation In article number 2100849, Wuming Wang, Gang Lu, Wai‐Yee Chan, and co‐workers demonstrate the role of Pten in regulating cardiomyocyte differentiation by modulating non‐CG DNA methylation via Dnmt3. The cover shows the gene transcription process which resembles the train running on the railway and implies that the regulation mechanism of many biological processes remains unknown like the outer space. The study reveals that cardiac genes are regulated by non‐CG DNA methylation during cardiomyocyte differentiation. [Image: see text]

Boron Nitride Nanostripes In article number 2101455, Khadiza Ali, J. Enrique Ortega, Frederik Schiller, and co‐workers explore a novel approach to nanopatterning a material with practical technological impact, namely growing hexagonal boron nitride (hBN) mono‐layers on vicinal surfaces. hBN forms a continuous atomically‐thin carpet on a curved rhodium (Rh) crystal, revealing a transformation from 2D to 1D electronic band structure at the Rh(337) orientation through electron scattering at N‐step‐Rh interface bonding points. [Image: see text]

Nanomembrane Electronics In article number 2101037 by Woon‐Hong Yeo, Hyojung J. Choo, and co‐workers, a wireless, non‐invasive nanomembrane system is reported that integrates wearable printed electronics for real‐time, continuous monitoring of volumetric muscle loss (VML) on craniofacial muscles. The craniofacial VML model, using biopsy punch‐induced masseter muscle injury, shows impaired muscle regeneration. [Image: see text]

Bioinspired Biomaterials A silk cocoon is nestled within a mussel shell. Taking inspiration from the adhesive property of mussels and the assembly properties of silk materials new, water‐based, eco‐friendly glues with exceptional underwater adhesion performance can be formulated. More details can be found in article number 2004786 by Gianluca M. Farinola, Fiorenzo G. Omenetto, and co‐workers. [Image: see text]

In article number 2004319, Wantao Chen, Xu Wang and co‐workers report the restoration of H3k27me3 modification epigenetically silences circadian gene Cry1 expression and sensitizes leptin signaling to reduce obesity‐related properties. It implicates Kdm6a as an attractive drug target for obesity and metabolic disorders. [Image: see text]

In article number 2004872, Huanjun Chen, Shaozhi Deng, and co‐workers realize a nanoscale tailoring of mid‐infrared electromagnetic field localizations in van der Waals α‐MoO(3) microstructures of different shapes and sizes. This is enabled by the synergy of in‐plane hyperbolic phonon polaritons and spatial confinement effects. Furthermore, the authors show that orientation of the in‐plane isofrequency curve relative to the microstructure edge is a critical parameter governing the localized electromagnetic field distributions. [Image: see text]

In article number 2100532, Sri Ramulu Torati, CheolGi Kim, and co‐workers develop the magnetophoretic decoupler for the disaggregation and inter‐particle distance control of magnetic bead cluster for higher efficiency of bio‐carrier role. This magnetophoretic decoupler can split the multiple bead pairs in different directions using single driving force, and linearly control the inter‐particle distance between them through the angle of the external field. [Image: see text]

In article number 2004627, Xiao Lin, Yuxuan Mao, Lei Yang and co‐workers report an innovative multi‐functional ionic skin (MiS) with broad‐spectrum anti‐microbial activity and multi‐modal sensing capability for smart and expedited wound care. MiS demonstrates a revolutionary wound management solution that promotes wound healing, realizes real‐time wound diagnosis, and restores multi‐tactile sensing capability of skin, leading to a paradigm shift from conventional dressing to a smart and comprehensive wound management. [Image: see text]

In article number 2003535, Rongrong Zhu and co‐workers report the role of MgFe‐LDH nanoparticles as a promising LIF replacement in maintaining mESCs self‐renewal and pluripotency. Combined transcriptomic and proteomic analysis reveals that MgFe‐LDH could activate LIFR regulating signaling pathways, while the extra Fe(2+) provided by MgFe‐LDH also enhances TET1/2 abundance related to DNA demethylation. This biocompatible MgFe‐LDH nanoparticle favors economical and efficient replacement for LIF in large‐scale expansion of ESCs. [Image: see text]

The strain‐multiplexing capability of flexible‐template reconfigurable diffractive metalenses (FDMLs) holds assurance for advancing technologies for artificial intelligence sensors and actuators. These miniature metalens sensors could provide access to tunable bandwidth and focusing to accurately map external strain or forces. The large‐scale surface relief metalenses, fabricated by Rajib Ahmed and Haider Butt in article number 2003394, consist of metal‐coated hemispherical cavities in a hexagonal closepacked arrangement to enhance tunable focal length, numerical aperture, and fill factor, FF ~100%. [Image: see text]

In article number 2001955, André R. Studart, Andres F. Arrieta, and co‐workers demonstrate a family of mechanical metamaterials exploiting sheets patterned with locally bistable domes. The metamaterial's strong hierarchical response enables tunable mechanical properties and programmed geometry adaptation. The strain energy stored by local dome inversion simplifies soft robotics grippers' actuation and enables memory and computation of spatially‐distributed mechanical signals in thin skins. [Image: see text]

In article number 2001148, Moonsang Lee, Jeong Young Park, and co‐workers demonstrate that fast‐disappearing hot holes are directly visualized using photoconductive atomic force microscopy. Experimental and numerical analysis show that hot spots at the edge of plasmonic nanostructures of Au nanoprisms on p‐type GaN exhibit enhanced hot hole flux driven by surface plasmons. [Image: see text]

Little is known about how glycogen metabolism is manipulated during exercise. In article number 2001502, John Zhong Li, Tiemin Liu, Xingxing Kong, and coworkers identify that interferon regulatory factor 4 (IRF4) in skeletal muscle regulates glycogen metabolism and subsequent exercise capacity. This work reveals a regulatory pathway including IRF4/protein targeting to glycogen (PTG)/glycogen synthesis on controlling exercise capacity. [Image: see text]

In article number 2000843, Mariana Medina‐Sánchez and co‐workers demonstrate a spiralshaped micropropeller that can capture, transport, and release a zygote, actuated solely by an external rotating magnetic fi eld, as a noninvasive alternative concept to laparoscopy, that is, zygote intrafallopian transfer by micromotors. This procedure is envisioned to improve the embryo implantation rates, which nowadays is one of the main causes of miscarriage in assisted fertilization. [Image: see text]

In article number 2000098, Bo Liu, Chuanpeng Liu, Yongjun Dang, Cheng Luo, and co‐workers describe the fi rst covalent and allosteric inhibitors targeting RhoA, which had been deemed as an “undruggable” protein target. This study reveals a novel allosteric regulatory site within the Rho family, which could be exploited for anti‐metastasis drug development, and also provides a novel strategy for inhibitor discovery toward “undruggable” proteins. [Image: see text]

Present challenges in electrochromic devices include the limited transmissive and reflective inter‐switchability, while achieving high optical contrast, fast switching speed, and cycling stability, simultaneously. In article number 1903198, Pooi See Lee and co‐workers develop a quasi‐solid‐state tristate reversible electrochemical mirror device, which offers highly reversible switching between transparent, greyish‐blue, and mirror (reflective) optical states. The alloying approach facilitates the electrodeposition and dissolution of Cu mirror film, allowing enhanced device stability. [Image: see text]

In article number 1903642, Jan C. M. van Hest, Fei Peng, Yingfeng Tu, and co‐workers design an intelligent biomimetic nanocarrier, based on the crosslinking reaction of hyaluronic acid with the ancillary anticarcinogen cisplatin in the presence of doxorubicin‐decorated gold nanorods followed by cloaking of the cancer cell membrane. Upon NIR laser irradiation, in situ photothermal therapy is conducted which further induces hyperthermiatriggered on‐demand drug release from the nanogel reservoir to achieve a synergistic photothermal/chemo‐therapy. Cover image designed by Junbin Gao. [Image: see text]

In article number https://doi.org/10.1002/advs.201903142, Ayumi Ishii and Tsutomu Miyasaka demonstrate near‐infrared light emitting diodes based on an energy transfer from wide bandgap all inorganic perovskite to ytterbium ions as an emitter in the crystalline film. The high light‐emitting efficiency around 1000 nm in the perovskite‐based diodes provides a new possibility for future optical applications.

In article number https://doi.org/10.1002/advs.201901891, Dan Zhu, Peng Fei, and co‐workers develop an imaging technique, multiangle‐resolved subvoxel selective plane illumination microscopy (termed Mars‐SPIM), that can readily obtain the 3D digital atlas of a cleared whole mouse brain with an isotropic single‐cell resolution, in a short acquisition time of several minutes. It provides an efficient way to implement system‐level cellular analysis, such as the mapping of different neuron populations and tracing of long‐distance neural projections over the entire brain.

Humans are belittled in their confrontation with the ever expanding galaxies of multidrug‐resistant bacteria. New antibacterial agents are annulled by the emergence of sophisticated bacteria‐resistant strategies that are beyond the imagination of the human mind. In their exploration for new antimicrobial strategies against ESKAPE pathogens, humans have to adopt a surrealistic mindset to unlock their subconscious resourcefulness. In article number https://doi.org/10.1002/advs.201901872, Ji‐Hua Chen, Franklin R. Tay, Li‐Na Niu, and co‐workers review antimicrobial research on ESKAPE pathogens over the past five years and provide prospective clinical applications.

Electrochemical Computing System In article number 2104076, Megumi Akai‐Kasaya and co‐workers develop a simple computing system based on the ionic current of electrochemical solutions at micro‐scale electrodes. In this system, even deionized water can show great computational power in solving higher‐order nonlinear problems. The addition of polyoxometalate molecules diversifies the Faradic currents, which makes it better at predicting periodic signals. [Image: see text]

Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co‐workers, osteocyte neuropeptide Y (NPY)‐dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ‐Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone‐fat imbalance induced by aging and estrogen deficiency. [Image: see text]

Cancer Cells In article number 2101029 by Yihai Cao and co‐workers, it is shown that interleukin‐33 (IL‐33)‐activated macrophages protect melanoma cells from tumor‐infiltrating lymphocytemediated killing. This cover shows a new mechanism of immune T cell‐mediated cancer killing. In the tumor environment, macrophages produce proteases to affect the T cell and cancer cell interaction. The monkey king represents immune T cell, and the bull demon represents cancer cell. [Image: see text]

Epigenome‐Wide Association Study In article number 2100727 by Yongshuai Jiang, and co‐workers, the research process of Epigenome‐wide association study (EWAS), its application in biology and clinical translation are discussed. It concludes by analyzing the current limitations and forecasting the future of EWAS. A decade has passed since EWAS was applied to analyze complex diseases. The cover is full of blessings for the 10th anniversary of EWAS and expresses the dedication of researchers. [Image: see text]

Neuron‐Inspired Steiner Tree Networks In article number 2100141 by Min Gu and co‐workers, neuron‐inspired Steiner tree networks are proposed and studied as a new method to create low‐density metamaterials, where novel mechanical properties and photonic topological quasiparticles can be discovered. The Steiner tree networks not only demonstrate a twist‐induced mechanical property enhancement, but also host an exotic photonic Fermion resulting from accidental degeneracy. [Image: see text]

Spatial Micro‐Water Manipulation An octopus with homogeneously soft structure can easily hide in rocks, where an athlete can throw javelin in precisely controlled manner thanks to the articular structure. Nature designed these distinctive structures by adjusting the amount of water inside. For taking both of their kinematics, the spatial micro‐water molecule manipulation maneuvers the amount of water in the hydrogel enabling the alteration between two structures. More details can be found in article number 2102536 by Seung Hwan Ko and co‐workers. [Image: see text]

Wireless Soft Scalp Electronics The cover shows a wearable scalp electronic system with virtual reality for motor imagerybased brain‐computer interfaces. The all‐in‐one, portable soft system includes an array of soft microneedles, stretchable interconnectors, and flexible circuits in a wearable platform. More details can be found in article number 2101129 by Woon‐Hong Yeo and co‐workers. [Image: see text]

Real‐Time Internal Steam Pop Detection Steam pop is one of the possible threats during radiofrequency ablation (RFA), a minimally invasive therapy to eliminate the cancer tissues. In order to monitor this threat, a flexible thinfilm type multimodal (pressure, temperature) sensor was integrated into the RFA needle, and successfully detected the steam pop in real‐time in a clinical demonstration. More details can be found in article number 2100725 by Hyo Keun Lim, Inkyu Park, and co‐workers. [Image: see text]

Variable Stiffness Catheter In article number 2101290 by Quentin Boehler, Bradley J. Nelson, and co‐workers, a magnetically controlled catheter that is able to continuously change its stiffness is presented. Soft, magnetic tools that are enhanced with the capability to apply and control forces during surgical intervention can significantly improve outcome of the procedure. The capabilities are demonstrated by performing a fully robotic surgery for a challenging ophthalmic intervention. Image designed by Adrián Bago González. [Image: see text]

Wound Healing Excessive inflammation often impedes the healing of chronic wounds. In article number 2100293, Lucas Schirmer, Carsten Werner, and co‐workers report a glycosaminoglycan hydrogelcoated wound contact layer capable of selectively sequestering pro‐inflammatory chemokines. A large animal model of human wound healing disorders confirms that the approach dampens inflammation without affecting pro‐regenerative growth factors, thus expanding the scope of a new anti‐inflammatory therapy toward clinical use. [Image: see text]

Programmable Detection of SARS‐CoV‐2 In article number 2101155, Huilin Shao and co‐workers report the collaborative coupling of enzyme–DNA nanostructures to establish multi‐enzyme catalysis. Through programmable nanostructures and favorable equilibrium architecture, the technology achieves direct and sensitive detection of SARS‐CoV‐2 RNA in native patient samples, within 30 minutes at room temperature. [Image: see text]

Soft Pneumatic Actuators In article number 2100445, Chuan Qiao, Lu Liu, and Damiano Pasini propose a bi‐shell valve leveraging shell snap‐through buckling interaction for the rapid actuation of pneumatic soft actuators. A demonstrative experiment shows that the actuation time can be significantly reduced. The concept introduced here, offers a new function that is unattainable by existing soft valves used in soft robotics. [Image: see text]

Bioinspired Engineering In article number 2004383, Hamed Rajabi and co‐workers investigate the wing‐to‐wing coupling of nine castes and species of bees and wasps. They showed that the diverse morphologies of the coupling mechanisms in the examined insects can be linked to forces to which the couplings are subjected. The researchers design and fabricate multi‐degreeof‐freedom bee‐inspired joints that can be used in everyday life applications, for example in cartridge razors. [Image: see text]

Bi alloy was injected in situ into bone defects to replace bone tissue for support. At the same time, compared with the transmission of nerve sensory information in the normal part, the continuous temperature control (40‐45 °C) of Bi alloy induced by the remote alternation magnetic field of the magnetic coil blocked the transmission of pain signals from the nerve fibers around the bone defect to the spinal cord and brain, thus alleviating pain. More details can be found in article number 2100719 by Jing Liu and co‐workers. [Image: see text]

Dynamics of tissue revascularization, vessel maturation and remodeling remain poorly understood due to lack of suitable in vivo imaging tools. The new LSOM method offers a versatile tool for tissue engineering and regenerative medicine by empowering label‐free, noninvasive, longitudinal, highthroughput, and quantitative studies of microcirculation in processes associated with vascular remodeling and wound healing. More details can be found in article number 2004226 by Sabine Werner, Daniel Razansky, and co‐workers. [Image: see text]