Descriptor: "Cytochrome P-450 (CYP)" / Topic: biochemistry - Searchworks@Jio Institute Digital Library Search Results

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Start Over Descriptor "Cytochrome P-450 (CYP)" Topic biochemistry

Author: Ishikawa, Minoru, Yoshii, Hidefumi, and Furuta, Takeshi
Subjects: *CYCLODEXTRINS, *CYTOCHROME P-450, *CYTOCHROMES, *METALLOENZYMES, *METABOLISM, *BIOCHEMISTRY, *BIOTECHNOLOGY
Abstract: Cites a study examining the effects of modified cyclodextrins (CD) hydroxypropyl-β-CD and methyl-β-CD on cDNA-expressed human cytochrome P-450 (CYP) activities. Ability of modified CD to inhibit the activities of CYP2C19 and CYP3A4; Enhancement by CD of the CYP2C9 activity by 140 to 176 percent; Inhibition by methyl-β-CD of CYP1A2 and CYP2D6 at higher concentrations.
Published: 2005
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