1. The Role of Ribose on Oxidative Stress During Hypoxic Exercise: A Pilot Study
- Author
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Jeff C. John, Andrew W. Subudhi, John A. St. Cyr, Linda M. Shecterle, Karen L. Riska, Min-Xin Fu, and John G. Seifert
- Subjects
medicine.medical_specialty ,Free Radicals ,Ribose ,Medicine (miscellaneous) ,Pilot Projects ,medicine.disease_cause ,Antioxidants ,chemistry.chemical_compound ,Double-Blind Method ,Malondialdehyde ,Internal medicine ,Dietary Carbohydrates ,medicine ,Humans ,Ingestion ,Lactic Acid ,Hypoxia ,Exercise ,Cross-Over Studies ,Nutrition and Dietetics ,Lactate threshold ,Glutathione ,Carbohydrate ,Bicycling ,Oxygen ,Oxidative Stress ,Endocrinology ,chemistry ,Biochemistry ,Dietary Supplements ,Uric acid ,Oxidative stress - Abstract
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O(2) with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250 mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2 +/- 0.03 nM/mg and 0.26 +/- 0.29 microM, respectively) but were lower with ribose supplementation (0.04 +/- 0.03 nM/mg and 0.38 +/- 0.29 microM, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, 4.55 +/- 0.06 mg/dL vs. 4.67 +/- 0.06 mg/dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
- Published
- 2009