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The Ctenistini fauna of China is insufficient documented. In this paper the first Chinese species of the genus Ctenisomorphus Raffray, 1890, C. yinggelingensis sp. nov., is described and separated from congeners based on two male and four female specimens collected at Yinggeling Natural Reserve, Hainan Island, southern China. Images of the habitus and major diagnostic characters of the new species are provided. The taxonomic status of Largeyeus anhuianus J.-K. Li, 1993 distributed in Anhui, eastern China is discussed, and the genus is placed as a junior synonym of Poroderus Sharp, 1883 syn. nov., resulting in P. anhuianus comb. nov.

A new species of the primarily Australasian genus Eupines King, 1866, E. crinita Li, Nomura & Yin, sp. nov., is described from China and Japan, which is also the first record of the genus from the former country. Moreover, a new distributional record of E. sphaerica (Motschulsky, 1851) from China is provided.

Four new staphylinid species from China are described, based on material collected from Tangli Mountain, Yunnan: Euconnus (s. str.) vertexalis Li & Yin, sp. nov. and Syndicus (Semisyndicus) wangjisheni Li & Yin, sp. nov. of the subfamily Scydmaeninae, and Tmesiphorus tanglimontis Li & Yin, sp. nov. and Tribasodites tubericeps Li & Yin, sp. nov. of the subfamily Pselaphinae. Illustrations of the habitus and major diagnostic characters of each new species are provided.

Basing on alternative splicing events (ASEs) databases, the authors herein aim to explore potential prognostic biomarkers for cervical squamous cell carcinoma (CESC). mRNA expression profiles and relevant clinical data of 223 patients with CESC were obtained from The Cancer Genome Atlas (TCGA). Correlated genes, ASEs and percent-splice-in (PSI) were downloaded from SpliceSeq, respectively. The PSI values of survival-associated alternative splicing events (SASEs) were used to construct the basis of a prognostic index (PI). A protein-protein interaction (PPI) network of genes related to SASEs was generated by STRING and analysed with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Consequently, 41,776 ASEs were discovered in 19,724 genes, 2596 of which linked with 3669 SASEs. The PPI network of SASEs related genes revealed that TP53 and UBA52 were core genes. The low-risk group had a longer survival period than high-risk counterparts, both groups being defined according to PI constructed upon the top 20 splicing events or PI on the overall splicing events. The AUC value of ROC reached up to 0.88, demonstrating the prognostic potential of PI in CESC. These findings suggested that ASEs involve in the pathogenesis of CESC and may serve as promising prognostic biomarkers for this female malignancy.

Here, we elucidated the uptake and translocation of numerous halogenated organic compounds (HOCs) into corn and peanut throughout their life cycle cultivated in an agricultural field of an electronic waste recycling area, where plants were simultaneously exposed to contaminants in soil and ambient air. The geometric mean concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) were 22.3 and 11.9 ng/g in peanut and 16.6 and 13.6 ng/g in corn, respectively. Decabromodiphenyl ethane (DBDPE, 6.07 ng/g) and dechlorane plus (DPs, 6.22 ng/g) also showed significant concentrations in peanuts. The plant uptake was initiated from root absorption at the emergence stage but it was subsequently surpassed by leaves absorption from the air since the late seedling stage or early reproductive stage. There was a rapid uptake of lower halogenated HOCs at the early vegetative stages in both species. However, robust uptake of highly halogenated compounds at the reproductive stages suggests a delayed accumulation of them by the plants. PBDE and PCB congener profiles suggest more noticeable tendency for inter-compartment translocation in peanut than in corn during the plant development. The DP and HBCD isomeric compositions in peanut (enriched with syn-DP and γ-HBCD) were different from those in the rhizosphere soils and air, suggesting a more stereoisomer-selective uptake and/or biotransformation in this species compared to corn. The bioaccumulation factors for root-soil and stem-root of these HOCs in most cases were

Cerebral ischemia is a disease of ischemic necrosis of brain tissue caused by intracranial artery stenosis or occlusion and cerebral artery embolization. Neuroinflammation plays an important role in the pathophysiology of cerebral ischemia. Microglia, astrocytes, leukocytes and other cells that release a variety of inflammatory factors involved in neuroinflammation may play a damaging or protective role during the process of cerebral ischemia. TP53-induced glycolysis and apoptotic regulators (TIGAR) may facilitate the production of nicotinamide adenine dinucleotide phosphoric acid (NADPH) via the pentose phosphate pathway (PPP) to inhibit oxidative stress and neuroinflammation. TIGAR can also directly inhibit NF-κB to inhibit neuroinflammation. TIGAR thus protect against cerebral ischemic injury. Exogenous NADPH can inhibit neuroinflammation by inhibiting oxidative stress and regulating a variety of signals. However, since NADPH oxidase (NOX) may use NADPH as a substrate to generate reactive oxygen species (ROS) to mediate neuroinflammation, the combination of NADPH and NOX inhibitors may produce more powerful anti-neuroinflammatory effects. Here, we review the cells and regulatory signals involved in neuroinflammation during cerebral ischemia, and discuss the possible mechanisms of targeting neuroinflammation in the treatment of cerebral ischemia with TIGAR/NADPH axis, so as to provide new ideas for the prevention and treatment of cerebral ischemia.