1. MicroRNA-1: Diverse role of a small player in multiple cancers
- Author
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Nivetha Sarah Ebenezer, Jawed A. Siddiqui, Mohd W. Nasser, Imayavaramban Lakshmanan, Ravi Salgia, Surinder K. Batra, Shailendra Kumar Maurya, and Parvez Khan
- Subjects
Male ,0301 basic medicine ,Tumor suppressor gene ,Angiogenesis ,Apoptosis ,Biology ,Article ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,microRNA ,medicine ,Humans ,Gene ,Cell Proliferation ,Neovascularization, Pathologic ,Mechanism (biology) ,High-Throughput Nucleotide Sequencing ,Cancer ,Cell Biology ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,The Hallmarks of Cancer ,Cancer research ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology extended beyond the protein-coding genes. It brought the functional role of noncoding RNAs into cancer-associated pathways. MicroRNAs (miRNAs) are one such class of noncoding RNAs regulating different cancer development aspects, including progression and metastasis. MicroRNA-1 (miR-1) is a highly conserved miRNA with a functional role in developing skeletal muscle precursor cells and cardiomyocytes, and acts as a consistent tumor suppressor gene. In humans, two discrete genes, MIR1–1 located on 20q13.333 and MIR1–2 located on 18q11.2 loci, encode for a single mature miR-1. Dysregulation or downregulation of miR-1 has been demonstrated in multiple cancers, including lung, breast, liver, prostate, colorectal, pancreatic, medulloblastoma, and gastric cancer. A vast number of studies have shown that miR-1 affects the multiple hallmarks of cancer like proliferation, invasion and metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation. The potential therapeutic applications of miR-1 in multiple cancer pathways provide a novel platform for developing anticancer therapies. This review focuses on the different antitumorigenic and therapeutic aspects of miR-1 including how it regulates tumor development and associated immunogenic functions.
- Published
- 2022