1. Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma.
- Author
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Wang, Cong, Li, Qingbao, Liu, Fang, Chen, Xuan, Nesa, Effat Un, Guan, Shanghui, Liu, Bowen, Han, Lihui, Tan, Bingxu, Wang, Ding, Chen, Pengxiang, Liu, Xiaoyue, Zhang, Han, Sun, Ying, and Cheng, Yufeng
- Subjects
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SERUM , *BIOMARKERS , *ESOPHAGEAL cancer , *SQUAMOUS cell carcinoma , *POLYMERASE chain reaction - Abstract
We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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