1. Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome.
- Author
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Xuan, Jingxiu, Wang, Ying, Xiong, Yingling, Qian, Hongyan, He, Yan, and Shi, Guixiu
- Subjects
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SJOGREN'S syndrome diagnosis , *AUTOANTIBODIES , *CHINESE people , *BIOMARKERS , *SALIVARY gland physiology , *DISEASES - Abstract
In order to evaluate autoantibody to SP-1 as an early biomarker in pSS, we investigated autoantibody to SP-1 in Chinese patients with primary Sjögren's syndrome (pSS). Autoantibodies to SP-1 are significantly increased in pSS patients compared to RA patients, SLE patients, and healthy people without secondary SS. The presence of anti SP-1 antibodies was negatively correlated with the focus score (FS), RF, and salivary gland function. It was positively correlated with FS = 0, RF ≤ 20, and normal salivary gland function. In further studies, the autoantigen SP-1 was identified in ductal epithelia of salivary glands in il14α TG mice by IIF. SP-1 mRNAs expression increased with growing age in il14α TG mice. SP-1 mRNA was also identified in labial biopsies of patients with pSS. In conclusion, autoantibody to SP-1 is an early marker in pSS. It is useful to diagnose pSS patients who lack RF or antibodies to Ro/La. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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