1. Abnormal expression levels of sMICA and NKG2D are correlated with poor prognosis in pancreatic cancer
- Author
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Hong Xu, Jiong Chen, and Xing-Xing Zhu
- Subjects
medicine.medical_specialty ,Pathology ,Therapeutics and Clinical Risk Management ,medicine.disease_cause ,Gastroenterology ,Metastasis ,Internal medicine ,Pancreatic cancer ,medicine ,Pharmacology (medical) ,Pancreatic carcinoma ,General Pharmacology, Toxicology and Pharmaceutics ,Survival analysis ,Rank correlation ,Original Research ,Chemical Health and Safety ,pancreatic carcinoma ,business.industry ,biomarkers ,General Medicine ,medicine.disease ,NKG2D ,immunohistochemistry ,Immunohistochemistry ,business ,Carcinogenesis ,Safety Research - Abstract
Jiong Chen,1,2,* Hong Xu,1,2,* Xing-Xing Zhu1,21Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University, 2Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, People’s Republic of China*These authors contributed equally tothis workAbstract: Soluble major histocompatibility complex class I-related chain A molecules (sMICA) and natural-killer group 2 member D (NKG2D) not only correlate with tumorigenesis and progression, but also with tumor invasion and metastasis. In this study, we used immunohistochemistry to investigate the correlation and prognostic significance of the differential expression of sMICA and NKG2D in pancreatic carcinoma and paracarcinoma tissues from 70 patients with pancreatic carcinomas. The results showed that sMICA expression was significantly (P
- Published
- 2015