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Cilj istraživanja: Iako se titanijum (Ti) temeljeni dentalni implantati smatraju bioinertnima, potvrđeno je kao su podložni koroziji i trošenju. Cilj ove in vivo provedene studije bio je procijeniti genotoksičan potencijal dvije vrste dentalni implantata u gingivnim epitelnim stanicama. Materijali i metode: U 78 ispitanika uzeti su uzorci oljuštenih gingivnih stanica tri puta. Prije postavljanja dentalnih implantata (T0), 90 dana nakon implantacije - neposredno prije postavljanja gingiva formera (T1) te 21 dan od postavljanja gingiva formera (T2). DNK oštećenje je procjenjivano mikronukleus testom. Rezultati: Dobiveni rezultati pokazuju kako nakon postavljanja obje vrste ispitivanih dentalnih implantata (Ankylos i Dentium) dolazi do značajnog povećanja broja binuklearnih stanica u odnosu na početne vrijednosti (T0 naspram T1; p = 0,011 i p ≤ 0,001). Također u odnosu na početne vrijednosti, nakon postavljanja gingiva formera (T0 naspram T2) kod ispitanika dolazi do značajnog povećanja broja stanica s mikronukleusom (p = 0,007 i p = 0,022) i binuklearnih stanica (p = 0,006 i p ≤ 0,001). Zaključak: Na osnovu dobivenih rezultata može se zaključiti kako titanijum temeljeni dentalni implantati ne izazivaju citotoksične i genotoksične učinke u gingivnim stanicama nakon postavljanja. Uočeni blagi učinci ne mogu se označiti kao biološki relevantni., Objective: Although titanium (Ti) based implants are considered bioinert, it has been found that they can undergo corrosion and wear. The aim of this in vivo study was to evaluate genotoxic potential from two different implants in gingival epithelial cells. Material and methods: Exfoliated gingival cells were taken from 78 participants three times. Before implant insertion (T0), 90 days following dental implant insertion immediately before gingiva former placement (T1), and 21 days following gingiva former placement (T2). DNA damages were analyzed using the micronucleus test. Results: Obtained average cytogenetic damage values in individuals after implementation of both tested dental implants, Ankylos (Dentsply Implants Manufacturing GmbH, Mannheim, Germany) and Dentium (Dentium Co., Seoul, Korea), showed a significant increase only in the number of binuclei (T0 vs T1; p =0.011 and p ≤ 0.001). Until, frequency of cells with micronuclei (p = 0.007 and p = 0.022) and binuclei (p= 0.006 and p ≤ 0.001) were significantly higher 21 days following gingiva former placement (T0 vs T2). Conclusion: Based on the results, can be concluded that there is no Ti based implants dependent cytotoxic or genotoxic effect in gingival epithelial cells. The biological relevance of the observed slightly increased cytogenetic damages cannot be assessed.

Cilj istraživanja: Svrha ovog istraživanja bila je utvrditi promjene kefalometrijskih varijabli koje nastaju zbog resorpcije gornje i donje čeljusti ispod baze potpunih proteza u razdoblju od pet godina te ispitati postoji li povezanost između spola ispitanika s brzinom resorpcije čeljusti. Materijali i metode: U ispitivanju je sudjelovao 31 ispitanik. Napravljena su dva telerendgenograma, jedan prilikom predaje proteza, a drugi nakon pet godina nošenja proteza. Sva su snimanja vršena na istom rendgenskom aparatu (Simens Roentgen Kugel 2E) uz upotrebu istog kefalostata te konvencionalnog rendgenskog filma (AGFA-ORTHO CP–G PLUS). Statistička analiza napravljena je s pomoću statističkoga paketa SPSS 12.0. (Statistical package for Social Science, Chicago, Illinois, USA). Rezultati: Rezultati pokazuju da je kod svih ispitanika došlo do statistički značajne resorpcije rezidualnoga grebena, odnosno do promjena karakteriziranih smanjenjem donje trećine lica (ANS-Xi/Xi-Pm, SN/Go-Gn, Go-Gn/ANS-PNS, ANS-Me) i pomicanjem mandibule prema naprijed (FH/N-Pog, SNPog, SNB, ANB). Nisu dokazane statistički značajne razlike između spolova u nijednoj ispitivanoj kefalometrijskoj varijabli. Zaključak: Tijekom petogodišnjeg razdoblja nošenja potpunih zubnih proteza dolazi do značajnih promjena u kefalometrijskim varijablama koje su povezane s pomakom mandibule prema naprijed te sa smanjenjem donje trećine lica. Na temelju dobivenih rezultata ne možemo zaključivati o utjecaju spola na brzinu resorpcije rezidualnog grebena., Objectives: The aim of this study was to measure the rate of mandibular and maxillary alveolar ridge resorption under the base of complete dentures through a five year period of denture wearing, and to assess the correlation between gender and the rate of residual alveolar ridge resorption. Materials and Methods: Thirty one participants were included in this study. The first lateral cephalogram was obtained at the delivery of complete dentures. The second lateral cephalogram was obtained after five years of denture wearing. Cephalograms were produced using Simens Roentgen Kugel 2E. The same cephalostat was used throughout the study and all films were AGFA-ORTHO CP–G PLUS. Statistical analysis was performed on selected craniograms using SPSS 12.0. (Statistical package for Social Science, Chicago, Illinois, USA). Results: All participants showed significant reduction (resorption) of residual alveolar ridges, the reduction of the height of the lower third of the face and the forward shifting of the mandible. There was no statistically significant correlation between gender and the rate of residual alveolar ridge resorption. Conclusion: Significant changes of cephalometric measurments after five years of wearing complete dentures were related to the reduction of the height of the lower third of the face and the forward shifting of the mandible. Further investigation is necessary to assess the correlation between gender and the rate of residual alveolar ridge resorption.