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In this research, epigenetic effects of bisphenol A (BPA) on human breast cancer MCF-7 cells were analyzed. Genome-wide DNA methylation and gene expression were analyzed in MCF-7 cells exposed to BPA (10−5 and 10−6 mol/L for 5 weeks). No significant changes in the global level of 5-methyl-2′-deoxycytidine and 5-hydroxymethyl-2′-deoxycytidine were observed. DNA methylation profiling analysis indicated that BPA exposure resulted in the hypermethylation of FOXK2, LKB1, LMX1A and CUGBP2 and the hypomethylation of PTPRN2, TRIM27, BCAS3 and ZNF423. Decreased expression of apoptosis genes (P38 and BCL2L1) and increased expression of chemokine (Cxcl2 and ccl20) were detected. Changes of these genes were speculated to affect the ERα-related cell growth as well as cell apoptosis. [ABSTRACT FROM AUTHOR]

Achieving both rapid adsorption rate and high adsorption capacity for bisphenol micropollutants from aquatic systems is critical for efficient adsorbents in water remediation. Here, we elaborately prepared three nitrogen-rich triazine-based porous polymers (NTPs) with similar geometric configurations and nitrogen contents (41.70–44.18 wt%) while tunable BET surface areas and micropore volumes in the range of 454.7–536.3 m2 g−1 and 0.20–0.84 cm3 g−1, respectively. It was systematically revealed that the synergy of hydrogen bonding, π−π electron-donor-acceptor interaction, and micropore preservation promoted the rapid (within 5 min) and high capacity adsorption of bisphenols by NTPs. Particularly, microporous-dominated NTPs-3 with the highest micro-pore volume (0.84 cm3 g−1) displays remarkable adsorption capacity towards bisphenol A as evidenced by the adsorption capacity of 182.23 mg g−1. A simple column filter constructed by NTPs-3 also expressed good dynamic adsorption and regeneration capacity. This work provided new insight into the rational design and engineering of nitrogen-rich porous polymers for the remediation of micropollutant wastewater. Three nitrogen-rich triazine-based porous polymers with similar geometric configurations and nitrogen contents while tunable BET surface areas and micropore volumes were used for the adsorption of bisphenol micropollutants. [Display omitted] • NTPs have similar geometric configurations and nitrogen contents while tunable porosities. • The adsorption mechanism is the synergy of hydrogen bonding, π−π interaction, and micropore preservation. • NTPs-3 expressed rapid and high capacity adsorption of bisphenols. • A simple column filter constructed by NTPs expressed good dynamic adsorption and regeneration capacity. [ABSTRACT FROM AUTHOR]