1. Acetylthiocholine (ATC)--cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea.
- Author
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Choi JY, Yu J, Yang DB, Ra K, Kim KT, Hong GH, and Shin KH
- Subjects
- Animals, Bivalvia metabolism, Chlorpyrifos toxicity, Diazinon toxicity, Dose-Response Relationship, Drug, Organothiophosphorus Compounds toxicity, Republic of Korea, Water Pollutants, Chemical toxicity, Acetylthiocholine metabolism, Bivalvia drug effects, Cholinesterase Inhibitors toxicity, Cholinesterases metabolism, Pesticides toxicity
- Abstract
The acetylthiocholine (ATC) - cleaving cholinesterase (ChE) activity in Manila clam, which is widely distributed throughout the coastal environment of Korea, was assayed as a potentially useful biomarker of organophosphorous pesticides (OPs). A clear dose-response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea. The measured EC(50)-24 h values of methidathion, chlorpyrifos, diazinon, and IBP for Ruditapes philippinarum were 7.16 μg l(-1), 0.34 mg l(-1), 3.01 mg l(-1), and 3.41 mg l(-1), respectively. In field studies, ChE activity in Manila clams collected from 23 stations in the mid-western coastal region demonstrated spatial variation with statistical differences. These results suggest that ChE activity in R. philippinarum is a potential biomarker for assessing organophosphorous pesticide contamination in coastal environments., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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