1. Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease.
- Author
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Koeyers, Wendy Jane, Van Der Geer, Simone, and Krekels, Gertruud
- Subjects
- *
PEMPHIGUS treatment , *BOTULINUM toxin , *IMMUNOLOGICAL adjuvants , *THERAPEUTICS , *KERATINOCYTES - Abstract
Background: Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed. Objective: To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease. Methods: The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport® was started in all six cases. Results: Marked improvement of the lesions was achieved with few side effects in all patients. Conclusion: Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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