1. Utility of icobrain for brain volumetry in multiple sclerosis clinical practice.
- Author
-
Nguyen AL, Sormani MP, Horakova D, Havrdova EH, Barnett MH, De Stefano N, Battaglini M, Vaneckova M, Lui E, Gaillard F, Desmond PM, Prime H, Datta M, Van der Walt A, Jokubaitis VG, Podevyn F, Zivadinov R, Weinstock-Guttman B, D'hooghe MB, Nagels G, Van Pesch V, Laureys G, Van Hijfte L, Lechner-Scott J, Patti F, Cristiano E, Rojas JI, Sima DM, Van Hecke W, Kalincik T, and Butzkueven H
- Subjects
- Humans, Female, Adult, Retrospective Studies, Male, Middle Aged, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology, Multiple Sclerosis, Relapsing-Remitting diagnostic imaging, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting pathology, Organ Size, Magnetic Resonance Imaging, Brain diagnostic imaging, Brain pathology
- Abstract
Background: Few studies on multiple sclerosis (MS) have explored the variability of percentage brain volume change (PBVC) measurements obtained from different clinical MRIs. In a retrospective multicentre cohort study, we quantified the variability of annualised PBVC in clinical MRIs., Methods: Clinical MRIs of relapse-onset MS patients were assessed by icobrain. Volumetric data were analysed on same-scanner and different-scanner MRI pairs if they passed quality control criteria. Alignment similarity between two images had to be comparable to same-scanner scan-rescan images., Results: Of 6826 MRIs, 85 % had appropriate volumetric sequences and 4446 serial MRI pairs were analysed. 3334 (75 %) MRI pairs from 1207 patients met the inclusions. The PBVC of included MRI pairs showed variance of 0.78 % for same-scanner pairs and 0.80 % for different-scanner pairs. Further selection of included MRI pairs with the best variance resulted in 1885 (42 %) MRI pairs with PBVC variance of 0.34 %. Excluded MRI pairs with poor alignment similarity had variances of 2.97 % for same-scanner pairs and 20.79 % for different-scanner pairs., Conclusion: Icobrain should be utilised for PBVC determination only on selected MRIs with the best alignment similarity. Applying strict selection criteria for the included MRI pairs and longitudinal imaging on the same scanner remain mandatory to reduce PBVC variability., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Wim Van Hecke reports a relationship with Icometrix NV that includes: board membership and equity or stocks. Diana M. Sima reports a relationship with Icometrix NV that includes: employment. Guy Nagels reports a relationship with Icometrix NV that includes: consulting or advisory and equity or stocks. Femke Podevyn reports a relationship with Icometrix NV that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
- Full Text
- View/download PDF