1. Brief Report
- Author
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Agsalda-Garcia, Melissa A, Sithinamsuwan, Pasiri, Valcour, Victor G, Chalermchai, Thep, Tipsuk, Somporn, Kuroda, Jason, Nakamura, Christie, Ananworanich, Jintanat, Zhang, Guangxiang, Schuetz, Alexandra, Slike, Bonnie M, and Shiramizu, Bruce
- Subjects
Neurosciences ,Clinical Research ,Mental Health ,Brain Disorders ,HIV/AIDS ,Infectious Diseases ,Genetics ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,AIDS Dementia Complex ,Cytokines ,Gene Expression Profiling ,HIV Infections ,Humans ,Leukocytes ,Mononuclear ,Lipopolysaccharide Receptors ,Monocytes ,Viral Load ,SEARCH 011 Study Group ,Clinical Sciences ,Public Health and Health Services ,Virology - Abstract
Monocytes play a vital role in HIV-associated neurocognitive disorder (HAND), postulated to transport HIV into the brain and secrete pro-inflammatory cytokines. We analyzed cytokines released by cultured peripheral blood mononuclear cells enriched with the CD14 marker isolated from HIV-infected individuals with HAND and normal cognition (NC) in combination antiretroviral therapy naive and after 1 year on treatment. Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline (P = 0.002 and P < 0.0001). These cytokines remained higher in HAND patients 1 year after combination antiretroviral therapy and were significant when NC patients who were initially HAND were excluded (P = 0.012 and P = 0.002). Both correlated with baseline CD14 peripheral blood mononuclear cell HIV DNA levels supporting the role of HIV DNA reservoir size and monocyte cytokines in HAND persistence.
- Published
- 2017