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Your search keyword '"Horowitz, Netanel A."' showing total 5 results
Start Over Author "Horowitz, Netanel A." Topic brain-derived neurotrophic factor
5 results on '"Horowitz, Netanel A."'

1. Brain-derived neurotrophic factor in hematological malignancies: From detrimental to potentially beneficial.

Author

Azoulay D and Horowitz NA

Subjects
Animals, Humans, Receptor, trkB genetics, Receptor, trkB metabolism, Brain-Derived Neurotrophic Factor genetics, Brain-Derived Neurotrophic Factor metabolism, Hematologic Neoplasms genetics, Hematologic Neoplasms therapy
Abstract

Emerging studies have highlighted brain-derived neurotrophic factor (BDNF), a neuronal growth factor abundant in the peripheral blood, and its tyrosine kinase receptor TRKB, as onco-genes and proteins that support the survival of malignant hematological cells. In contrast, other researchers reported on a favorable association between BDNF blood levels and prognosis, chemotherapy response and neurological side effects in patients with hematological malignancies. Here, we review the accumulated data regarding the expression of BDNF and its receptors in normal hematopoietic and lymphatic cells and tissue. In addition, in-vitro experiments, animal models and human sample studies that investigated the role of BDNF and its receptors in hematological malignancies are discussed. Finally, directions for future research aimed at revealing the mechanisms underlying the protective effect of BDNF in patients with these diseases are suggested., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2022
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2. Brain derived neurotropic factor single nucleotide polymorphism Val66Met and serum protein levels are associated with development of vincristine-induced peripheral neuropathy in patients with lymphoma.

Author

Azoulay D, Nasser R, Sharon R, Simanovich L, Akria L, Shaoul E, and Horowitz NA

Subjects
Alleles, Disease Susceptibility, Female, Genotype, Humans, Lymphoma drug therapy, Male, Vincristine therapeutic use, Amino Acid Substitution, Brain-Derived Neurotrophic Factor blood, Brain-Derived Neurotrophic Factor genetics, Lymphoma complications, Lymphoma genetics, Peripheral Nervous System Diseases etiology, Polymorphism, Single Nucleotide, Vincristine adverse effects
Published
2019
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3. Brain derived neurotropic factor single nucleotide polymorphism Val66Met and serum protein levels are associated with development of vincristine‐induced peripheral neuropathy in patients with lymphoma.

Author

Azoulay, David, Nasser, Roni, Sharon, Rivka, Simanovich, Liya, Akria, Luiza, Shaoul, Ety, and Horowitz, Netanel A.

Subjects
BRAIN-derived neurotrophic factor, SINGLE nucleotide polymorphisms, BLOOD proteins, VINCRISTINE, PERIPHERAL neuropathy, LYMPHOMA treatment
Published
2019
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5. Bortezomib-induced peripheral neuropathy is related to altered levels of brain-derived neurotrophic factor in the peripheral blood of patients with multiple myeloma.

Author

Azoulay, David, Lavie, David, Horowitz, Netanel, Suriu, Celia, Gatt, Moshe E., Akria, Luiza, Perlman, Riki, Braester, Andrei, and Ben‐Yehuda, Dina

Subjects
MULTIPLE myeloma treatment, BORTEZOMIB, NEUROPATHY, BRAIN-derived neurotrophic factor, ALTERNATIVE medicine, BLOOD platelets
Abstract

The article discusses a study that describes alterations of bortezomib-induced peripheral neuropathy (BIPN) in patients with multiple myeloma (MM). It shows that reduced soluble brain-derived neurotrophic factor (sBDNF) levels in the plasma concomitant with elevated BDNF content in platelets of MM patients that developed BIPN. It unveils that the patients who developed BIPN had undetectable subclinical disease-related neuropathy before starting treatment.

Published
2014
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