1. Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068
- Author
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Chaomin Li, Yiqing Lin, John Guzowski, Lloyd Franklin, Brian T. Hopkins, Michael MacPhee, Daniel Patience, Bin Ma, Zheng Fengmei, Michael Humora, Robbie Chen, Erin M. O’Brien, George A. Moniz, William F. Kiesman, Steven Ferguson, and Tamera Mack
- Subjects
biology ,010405 organic chemistry ,Process development ,Chemistry ,Scale (chemistry) ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Scientific method ,biology.protein ,Bruton's tyrosine kinase ,Process optimization ,Physical and Theoretical Chemistry - Abstract
Chemical process development efforts leading to multikilogram production of BIIB068 hemiadipate are discussed. Process optimization resulted in (1) removal of transition metal from the process, (2)...
- Published
- 2020
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