Featured Application: The Louisiana State University (LSU) Windstorm Impact, Science, and Engineering (WISE) Open-Jet Testing facility is instrumental in enhancing structural resilience under windstorms. The facility represents a Mid-Scale Research Infrastructure to address grand challenges and the need for experimental capabilities in the mid-scale range. Its unique capabilities enable the comprehensive testing and evaluation of critical infrastructure components, encompassing low- and high-rise buildings, photovoltaic (PV) solar panels, wind turbines, bridges, vegetation (nature-based solutions), power transmission lines, and more. Through controlled wind conditions, researchers can gain invaluable insights into the behaviour and performance of these critical infrastructures. The facility is pivotal in advancing the design and engineering of robust, climate-resilient systems capable of withstanding the challenges posed by dynamic environmental conditions. The potential impact of this wind testing facility extends far beyond the boundaries of conventional engineering, offering a pathway towards a more sustainable and resilient built environment on a global scale. Experimental wind engineering is crucial for global structural design. This paper addresses limitations in aerodynamic testing, particularly in wall-bounded and small-scale scenarios. Open-jet testing, introduced as an advanced tool, overcomes turbulence modelling constraints, providing a more accurate representation of real-world conditions. The LSU WISE open-jet facility produces complete turbulence at a large scale, eliminating the need for corrections accompanied by partial turbulence simulation. This discovery holds significant implications in wind engineering and unsteady aerodynamics. Integrating photovoltaic panels with gable-roofed buildings may not require additional structural reinforcement, with a reduction in wind uplift forces by 45–63%. Building-integrated photovoltaics (BIPV) offer design flexibility and aesthetic appeal despite potential higher upfront costs. Strategic interventions, such as design optimization and cost-effective installation methods, can enhance the economic viability of BIPV systems. Contrary to long-held beliefs, the findings challenge the notion that wind loads on structures with sharp corners are insensitive to Reynolds number. Open-jet testing produces higher peak pressures, providing real-world justification for actual damage in high-rise buildings. These results validate the author's hypothesis regarding the underestimation of peak loads (in small-scale testing) leading to cladding failure in high-rise buildings. They emphasize the superiority of large-scale open-jet testing, underscoring its critical role in designing resilient structures. The LSU WISE open-jet facility's unique capabilities hold immense promise for revolutionizing wind engineering, addressing grand challenges, and creating more resilient and sustainable infrastructure. Its applications span critical infrastructure, promising significant economic, societal, and educational impacts in STEM fields. [ABSTRACT FROM AUTHOR]