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1. [Effect of L-lysine-alpha-oxidase on the cell cycle kinetics of cultured Burkitt's lymphoma cells].

Author

Zhukova OS, Khaduev SKh, Dobrynin IaV, Smirnova MP, and Lukasheva EV

Subjects
Burkitt Lymphoma metabolism, Cell Cycle drug effects, Cells, Cultured, DNA, Neoplasm biosynthesis, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Humans, Neoplasm Proteins biosynthesis, RNA, Neoplasm biosynthesis, Time Factors, Trichoderma enzymology, Amino Acid Oxidoreductases toxicity, Burkitt Lymphoma pathology
Abstract

L-lysine-alpha-oxidase from Trichoderma sp. fungi inhibits the synthesis of DNA, RNA and protein in cultivated cells of the Burkitt lymphoma (strain P3HRj) in vitro, which results in the blocking of the cells' transfer from phase S to phase G2/M of the mitotic cycle.

Published
1985

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