1. Circulation of enterovirus A71 during 2019–2020, Marseille, France
- Author
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Aurélie Morand, Christine Zandotti, Géraldine Piorkowski, Léa Luciani, Antoine Nougairède, Aurélie Boutin, Philippe Minodier, Laetitia Ninove, Julie Mazenq, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Service de pédiatrie spécialisée et médecine infantile (neurologie, pneumologie, maladies héréditaires du métabolisme) [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service des urgences pédiatriques, CHU Timone, Service des urgences pédiatriques, CHU Nord AP-HM, and COMBE, Isabelle
- Subjects
Acute flaccid paralysis ,Genotype ,Genome, Viral ,medicine.disease_cause ,Viral Proteins ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Virology ,Enterovirus Infections ,medicine ,Humans ,Paralysis ,Viral rna ,030212 general & internal medicine ,Respiratory samples ,Phylogeny ,ComputingMilieux_MISCELLANEOUS ,Virus classification ,Retrospective Studies ,[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,business.industry ,Infant, Newborn ,Infant ,Enterovirus a71 ,Enterovirus A, Human ,3. Good health ,Treatment Outcome ,Infectious Diseases ,Child, Preschool ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,RNA, Viral ,Enterovirus ,030211 gastroenterology & hepatology ,France ,business ,Paediatric population - Abstract
Enteroviruses A71 (EVs-A71) are known to cause serious neurological infections, especially in the paediatric population. We report here eight cases of EV-A71 infection diagnosed in Marseille over the past two years (seven cases in 2019 and one case in 2020). Only children under 5 years of age were affected, including one case of acute flaccid paralysis. Viral RNA was detected by RT-PCR in peripheral samples for all cases (faeces and upper respiratory samples). Phylogenetic analyses based on VP1 and 2C3C coding regions revealed that all these cases of EV-A71 infection were caused by viruses belonging to the subgenogroup C1 that currently circulates in Europe and that these viruses are genetically closed to other EVs-A71 recently detected in European countries. These data therefore reinforce the usefulness of enterovirus surveillance network and the need of systematic screening for EV-A71 in case of enteroviral infection. This study therefore suggests that the systematic screening for EV-A71 in case of enteroviral infection could provide additional data for enterovirus surveillance networks. This article is protected by copyright. All rights reserved.
- Published
- 2021