1. The presence of an additional ventricular chamber does not change the outcome of Fontan circulation: a comparative study
- Author
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Giovanni Di Salvo, Massimo A. Padalino, Vladimiro L. Vida, Elena Rossi, Biagio Castaldi, Anna Chiara Frigo, Elena Reffo, and Giulio Cabrelle
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Heart Defects, Congenital ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Heart Ventricles ,medicine.medical_treatment ,Fontan circulation • Single ventricle • Congenital heart disease • Ventricular morphology • Outcomes ,030204 cardiovascular system & hematology ,Fontan Procedure ,Retrospective data ,Fontan circulation ,Fontan procedure ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Humans ,In patient ,Complex congenital heart disease ,Retrospective Studies ,business.industry ,General Medicine ,Treatment Outcome ,medicine.anatomical_structure ,030228 respiratory system ,Cardiac rhythm disturbances ,Ventricle ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES The role of an additional ventricle in patients with a functional single ventricle undergoing the Fontan operation has been debated due to conflicting data. Our goal was to report our experience with Fontan circulation for complex congenital heart disease, with a focus on the influence that an additional ventricular chamber may have on early and long-term clinical outcomes. METHODS We performed a retrospective clinical study including all patients undergoing the Fontan procedure between 1978 and 2019. Clinical data were retrieved from our institutional database. A ‘biventricular’ Fontan (BVF) was defined as that performed in a patient with single ventricle anomaly where an additional diminutive ventricular cavity was present at echocardiographic evaluation. RESULTS A total of 210 consecutive patients with functional single ventricle were included. Among these, 46 had BVF (21.9%). Early complications occurred in 42 patients (20.0%; 11 in BVF vs 31 in univentricular Fontan; P = 0.53) There were 18 early deaths (8.6%) with no difference between the groups. At a median follow-up of 12.7 years (interquartile range 5.4–20.7), there were no significant differences in late mortality, whereas cardiac rhythm disturbances resulted more frequently in univentricular Fontan (P = 0.018). Statistical analysis showed an equal distribution of BVF across time (P = 0.620), and there were no significant differences in terms of early and late survival (P = 0.53 and P = 0.72, respectively) or morbidity (P = 0.45 and P = 0.80, respectively). CONCLUSIONS A secondary ventricle in Fontan circulation is not significantly related to any clinical disadvantage in terms of survival or onset of complications. However, the immediate postoperative course may be influenced negatively by the presence of an additional secondary ventricle. more...
- Published
- 2021
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