1. Ferroptosis in the tumor microenvironment: perspectives for immunotherapy
- Author
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Di Ye, Hongying Zhang, Meiling Ren, Feng Bi, and Huanji Xu
- Subjects
Tumor microenvironment ,business.industry ,Ferroptosis ,medicine.medical_treatment ,Tumor cells ,Cancer immunity ,Immunotherapy ,Immune system ,Cancer immunotherapy ,Neoplasms ,Cancer cell ,Tumor Microenvironment ,medicine ,Cancer research ,Humans ,Molecular Medicine ,sense organs ,business ,Molecular Biology - Abstract
Targeting ferroptosis, which provokes lipid peroxidation in cancer cells, presents potentially new avenues for anticancer therapy. Recent studies have begun to explore how immune cells in the tumor microenvironment (TME) respond and adapt to lethal lipid peroxides (LPOs). A better understanding of this process in the TME is likely to uncover another side of ferroptosis in cancer immunity and promote the development of ferroptosis-targeted therapy. This Opinion article overviews the main metabolic processes in ferroptosis, summarizes the emerging roles of ferroptosis not only in immune cells in the TME but also in the crosstalk between tumor cells and immune cells, and presents a perspective on the targeting of ferroptosis in cancer immunotherapy.
- Published
- 2021